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Sleep State and Periodic Respiration

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Modeling and Parameter Estimation in Respiratory Control

Abstract

Periodic breathing occurs commonly in stage 1–2 non-rapid-eye-movement (NREM) sleep.1–4 When pronounced, apnea may occur at the nadir of ventilation. Thus, sleep apnea may be considered as a severe form of periodic breathing (see discussion, ref. 5). The degree of periodic breathing, however, varies with sleep stage. This was recognized in early, relatively qualitative studies.1,2 Recent quantitative studies in our laboratory have both confirmed and extended such earlier observations.4 The results of these studies led us to the hypothesis that oscillations in ventilation were secondary to oscillations in sleep state. Thus, in addition to the experimental studies, we have performed a theoretical study to determine the implications of the coupling between sleep state and ventilatory drive.

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Authors and Affiliations

  1. Pulmonary Section, Department of Medicine, University of Pennsylvania, Philadelphia, PA, USA

    Allan I. Pack, Michael Cola & Adrian Goldszmidt

  2. Department of Anesthesia, University of Pennsylvania, Philadelphia, PA, USA

    Allan Gottschalk

Authors
  1. Allan I. Pack
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  2. Allan Gottschalk
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  3. Michael Cola
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  4. Adrian Goldszmidt
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Editor information

Editors and Affiliations

  1. School of Engineering, University of Southern California, Los Angeles, California, 90089, USA

    Michael C. K. Khoo

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© 1989 Plenum Press, New York

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Pack, A.I., Gottschalk, A., Cola, M., Goldszmidt, A. (1989). Sleep State and Periodic Respiration. In: Khoo, M.C.K. (eds) Modeling and Parameter Estimation in Respiratory Control. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-0621-4_19

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  • DOI: https://doi.org/10.1007/978-1-4613-0621-4_19

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4612-7896-2

  • Online ISBN: 978-1-4613-0621-4

  • eBook Packages: Springer Book Archive

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