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Interactions Between the Human Trophoblast Cells and the Extracellular Matrix of the Endometrium. Specific Expression of α-Galactose Residues by Invasive Human Trophoblastic Cells

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Trophoblast Invasion and Endometrial Receptivity

Part of the book series: Trophoblast Research ((TR,volume 4))

Abstract

Mammalian embryo implantation takes place through a complex series of events resulting in apposition and attachment of the blastocyst to the uterine epithelium and subsequent invasion of the maternal endometrium. During invasion, the embryo penetrates the epithelium and basal lamina and invades the underlying stroma. Endometrial stromal cells secrete and deposit complex extracellular matrices (ECM) which play important roles in various physiologic and pathologic processes. In recent years, knowledge about the structure and function of ECM and their components has increased considerably. ECM are supramolecular complexes which constitute an extracellular environment influencing the differentiation, proliferation, organization, and attachment of cells. They play a key role in organogenesis, embryogenesis, and post-traumatic healing as well as in tumorigenesis, tumoral invasion and homing of metastatic tumor cells (Liotta, 1986; Bruijn et al., 1988).

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Authors and Affiliations

  1. Laboratory of Biology, University of Liege, Tower of Pathology (B35), Sart Tilman, B-4020, Liege, Belgium

    J. M. Foidart & Y. Christiane

  2. Laboratoire de Pathologie Cellulaire, CNRS UA 602, Institut Pasteur, F-69365, Lyon, France

    H. Emonard

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  1. J. M. Foidart
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  2. Y. Christiane
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  3. H. Emonard
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Editors and Affiliations

  1. University Clinics, Essen, Federal Republic of Germany

    Hans-Werner Denker

  2. St. Mary’s Hospital, Manchester, UK

    John D. Aplin

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© 1990 University of Rochester

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Foidart, J.M., Christiane, Y., Emonard, H. (1990). Interactions Between the Human Trophoblast Cells and the Extracellular Matrix of the Endometrium. Specific Expression of α-Galactose Residues by Invasive Human Trophoblastic Cells. In: Denker, HW., Aplin, J.D. (eds) Trophoblast Invasion and Endometrial Receptivity. Trophoblast Research, vol 4. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-0615-3_8

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  • DOI: https://doi.org/10.1007/978-1-4613-0615-3_8

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