Abstract
Implantation of the mammalian embryo in the uterine wall involves the attachment of the trophoblast to the uterine epithelial cells followed, in most species, by invasion of the trophoblast. The present state of knowledge about implantation results from morphological and histochemical examinations of embryos in situ and from limited experimental studies performed predominantly in vivo (c.f. Denker, 1977, 1983; Schlafke and Enders, 1975). Implantation is thought to start when the invasive phase of the trophoblast coincides with a “receptive state” of the endometrium (Psychoyos and Casimiri, 1980). While there is good evidence that endometrial receptivity is controlled by estrogens and progesterone (Psychoyos, 1976), the molecular interactions of the trophoblast and the endometrium as well as the changes in their cell physiological state that are required, remain largely unknown.
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Hohn, HP., Denker, HW. (1990). A Three-Dimensional Organ Culture Model for the Study of Implantation of Rabbit Blastocyst In Vitro. In: Denker, HW., Aplin, J.D. (eds) Trophoblast Invasion and Endometrial Receptivity. Trophoblast Research, vol 4. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-0615-3_4
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DOI: https://doi.org/10.1007/978-1-4613-0615-3_4
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