Histochemical Characteristics of the Endometrial Surface Related Temporally to Implantation in the Non-Human Primate (Macaca fascicularis)

  • Ted L. Anderson
  • James A. Simon
  • Gary D. Hodgen
Part of the Trophoblast Research book series (TR, volume 4)


Appropriate differentiation of the trophoblast is surely requisite for blastocyst invasion. However, there is overwhelmingly compelling evidence to suggest that differentiation of the endometrium into a “receptive state” is the primary determinate of successful nidation. The highly invasive trophoblast of certain species appears able to “implant” almost without discrimination in a variety of ectopic sites, regardless of the host tissue or the hormonal milieu (Kirby, 1971). Conspicuously, the only tissue in which trophoblastic invasion does no. occur indiscriminately is the natural implantation site, the uterine lining. The uterus is permissive to blastocyst implantation for only a brief interval or “receptive window” following appropriate hormonal conditioning (Casimiri and Psychoyos, 1981), as evidenced by the failure of transferred blastocysts to attach to endometrium except at the time of normal receptivity for that species (Finn, 1977). Further evidence is derived from observations that peri-ovulatory administration of progesterone leads to implantation failure due to embryo-uterine asynchrony in rats, rabbits and (albeit debated) humans (Psychoyos, 1976; Schacht and Foote, 1978; Trounson et al., 1986).


Sialic Acid Cynomolgus Monkey Luminal Surface Lectin Binding Luminal Epithelium 
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Copyright information

© University of Rochester 1990

Authors and Affiliations

  • Ted L. Anderson
    • 1
  • James A. Simon
    • 1
  • Gary D. Hodgen
    • 1
  1. 1.The Jones Institute for Reproductive Medicine, Laboratory for Cellular and Molecular Biology, Department of Obstetrics and GynecologyEastern Virginia Medical SchoolNorfolkUSA

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