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Uterine Receptivity to Implantation in the Rabbit: Evidence for a 42 kDa Glycoprotein as a Marker of Receptivity

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Trophoblast Invasion and Endometrial Receptivity

Part of the book series: Trophoblast Research ((TR,volume 4))

Abstract

The requirement for synchronous development of the mammalian embryo and uterus was evidenced by the failure of asynchronous embryo transfer to result in implantation except at the time of normal receptivity for each species (Chang, 1950; Finn, 1977). Evidence linking embryo-uterine synchrony to hormonal balance in the rabbit was based on steroid hormone-induced delay (Beier, 1976) or advancement (Adams, 1971; McCarthy et al., 1977) of uterine preparation relative to embryonic development; ovariectomy was directly lethal to contained blastocysts (Adams, 1958). That the epithelium constituted a major component of the “hostile uterine environment” resulting from inadequate hormone preparation was argued by Nilsson (1967) and Potts and Psychoyos (1967). Further support for this view was reported by Cowell (1969) who obtained “implantation”of mouse blastocysts in otherwise unreceptive uteri only after scraping of the epithelium to expose the underlying stroma. The uterine epithelium may be involved in a variety of implantation-related processes (absorption, secretion, barrier to trophoblast, message transduction to underlying tissues; Martin, 1980).

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Author information

Authors and Affiliations

  1. Department of Cell Biology, Vanderbilt University School of Medicine, 37232, Nashville, Tennessee, USA

    Loren H. Hoffman, Virginia P. Winfrey, Ted L. Anderson & Gary E. Olson

Authors
  1. Loren H. Hoffman
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  2. Virginia P. Winfrey
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  3. Ted L. Anderson
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  4. Gary E. Olson
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Editors and Affiliations

  1. University Clinics, Essen, Federal Republic of Germany

    Hans-Werner Denker

  2. St. Mary’s Hospital, Manchester, UK

    John D. Aplin

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© 1990 University of Rochester

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Hoffman, L.H., Winfrey, V.P., Anderson, T.L., Olson, G.E. (1990). Uterine Receptivity to Implantation in the Rabbit: Evidence for a 42 kDa Glycoprotein as a Marker of Receptivity. In: Denker, HW., Aplin, J.D. (eds) Trophoblast Invasion and Endometrial Receptivity. Trophoblast Research, vol 4. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-0615-3_12

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  • DOI: https://doi.org/10.1007/978-1-4613-0615-3_12

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4612-7893-1

  • Online ISBN: 978-1-4613-0615-3

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