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Trophoblast - Endometrial Interactions at Embryo Implantation: A Cell Biological Paradox

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Trophoblast Invasion and Endometrial Receptivity

Part of the book series: Trophoblast Research ((TR,volume 4))

Abstract

Invasion of the trophoblast into the endometrium, which forms an essential element of embryo implantation in most mammalian species including the human, has long impressed investigators. It resembles invasion of malignant tumors in many respects, including host tissue destruction, blood vessel erosion, a certain degree of repair processes and neovascularization (cf. Denker, 1977, 1980, 1983). It presents an immunologic paradox appearing to violate transplantation laws: antigenically different cells being tolerated within a basically immunocompetent milieu (cf. Bulmer et al., 1990; Loke et al., 1990).

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Authors and Affiliations

  1. Institut für Anatomie, Universitätsklinikum, Hufelandstr. 55, D-4300, Essen 1, Federal Republic of Germany

    H.-W. Denker

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  1. H.-W. Denker
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  1. University Clinics, Essen, Federal Republic of Germany

    Hans-Werner Denker

  2. St. Mary’s Hospital, Manchester, UK

    John D. Aplin

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© 1990 University of Rochester

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Denker, HW. (1990). Trophoblast - Endometrial Interactions at Embryo Implantation: A Cell Biological Paradox. In: Denker, HW., Aplin, J.D. (eds) Trophoblast Invasion and Endometrial Receptivity. Trophoblast Research, vol 4. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-0615-3_1

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  • DOI: https://doi.org/10.1007/978-1-4613-0615-3_1

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  • Online ISBN: 978-1-4613-0615-3

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