Immunocompetent-Like Cells in Human Fetal Brain Cultures
The role played by endogenous brain cells in the pathogenesis of several diseases of the human Central Nervous System (CNS) is still rather obscure. In brain, besides neurons, other cells are present, like microglial cells, which are believed to be macrophage precursors and have been shown to express in vitro Fc receptors and to phagocytose.1 Moreover, the presence of pluripotential hemopoietic stem cells in adult mouse brain has been reported.2 Recent studies have also shown that astrocytes can act as macrophages3 and, under appropriate stimulation, as antigen-presenting cells.4 Purified astrocyte cultures from mammalian brain can produce interleukin I, II and III-like molecules, 5,6 further substantiating the hypothesis that glial cells can play an autonomous role in the immunological events of CNS.
KeywordsGlial Fibrillary Acidic Protein Human Central Nervous System Human Fetal Brain Adult Mouse Brain Human Fetal Astrocyte
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