A New Strategy for the Study of Intrathecal Immunity

  • E. Schüller


In its normal state, the central nervous system (CNS) is protected from the circulating immune system. However, each neuro-immunological process can break this sanctuary by two different ways: (1) transudation, a pathological influx of proteins from blood; and (2) intrathecal production of the immune system proteins such as immunoglobulins synthesized by B lymphocytes or complement components by macrophages and probably astrocytes. These two processes can occur either separately or together: the basic question is thus to evaluate the respective contribution of each of these processes when one of these immune proteins is increased in the CSF.


Multiple scleroSiS Multiple scleroSiS Patient Subacute Sclerosing Panencephalitis Intrathecal Synthesis Serological Titre 
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intrathecal synthesis




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Copyright information

© Plenum Press, New York 1990

Authors and Affiliations

  • E. Schüller
    • 1
  1. 1.Hôpital de la SalpêtrièreParis Cedex 13France

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