Fluid and Electrolyte Homeostasis During and Following Exercise: Hormonal and Non-Hormonal Factors

  • Charles E. Wade
  • Beau J. Freund
  • John R. Claybaugh


Precise control of fluid and electrolyte homeostasis is essential for the survival of man. The performance of exercise results in a significant disturbance of water and electrolyte homeostasis. These alterations during exercise are due to the loss of fluids and electrolytes primarily in sweat and to voluntary dehydration associated with an inappropriate suppression of thirst. During the performance of exercise, as well as during recovery, compensatory measures occur to rectify these changes. A variety of hormones are important in the compensatory responses to correct water and electrolyte disturbances. The goal of this chapter is to describe the changes in water and electrolyte homeostasis resulting from exercise and the responses, regulation, and actions of the hormones important in correcting these imbalances.


Atrial Natriuretic Peptide Plasma Renin Activity Renal Blood Flow Maximal Exercise Plasma Osmolality 
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  1. 1.
    Adlercreutz, H., Haerkoenen, M., Kuoppasalmi, K., Kosunen, K., Naeveri, H. and Rehunen, S. Physical activity and hormones. Adv Cardiol 18: 144–157, 1976.PubMedGoogle Scholar
  2. 2.
    Adolph, E.F. Regulation of water intake in relation to body water content. In: Handbook of Physiology: Alimentary Canal. Food and Water Intake, edited by Washington, DC: American Physiology Society, 1967, p. 163–172.Google Scholar
  3. 3.
    Anderson, R.J., Berl, T., McDonald, K.M. and Schrier, R. Evidence for an in vivo antagonism between vasopressin and prostaglandin in the mammalian kidney. J Clin Invest 56: 420–426, 1975.PubMedGoogle Scholar
  4. 4.
    Andersson, B. Regulation of water intake. American Physiological Society 58: 582–603, 1978.Google Scholar
  5. 5.
    Annat, G., Guell, A., Gauquelin, G., Vincent, M., Mayet, M.H., Bizollon, Ch.A., Legros, J.J., Potter, M. and Gharib, C. Plasma vasopressin, neurophysin, renin and aldosterone during a 4-day head-down bed rest with and without exercise. Eur J Applied Physiol 55: 59–63, 1986.Google Scholar
  6. 6.
    Armsen, T. and Reinhardt, H.W. Transtubular movement of urea at different degrees of water diuresis. Pflugers Arch 326: 270–280, 1971.PubMedGoogle Scholar
  7. 7.
    Astrand, P. and Saltin, B. Plasma and red cell volume after prolonged severe exercise. J Appl Physiol 19: 829–832, 1964.PubMedGoogle Scholar
  8. 8.
    Atherton, J.C., Evans, J.A., Green, R. and Thomas, S. Influence of variations in hydration and in solute excretion on the effects of lysine-vasopressin infusion on urinary and renal tissue composition in the conscious rat. J Physiol 213: 311–327, 1971.PubMedGoogle Scholar
  9. 9.
    Atherton, J.C., Green, R. and Thomas, S. Influence of lysine-vasopressin dosage on the time course of changes in renal tissue and urinary composition in the conscious rat. J Physiol 213: 291–309, 1971.PubMedGoogle Scholar
  10. 10.
    Aurell, M., Carlsson, M., Grimby, G. and Hood, B. Plasma concentration and urinary excretion of certain electrolytes during supine work. J Appl Physiol 22: 633–638, 1967.PubMedGoogle Scholar
  11. 11.
    Aurell, M. and Vikgren, P. Plasma renin activity in supine muscular exercise. J Appl Physiol 31 (6): 839–841, 1971.PubMedGoogle Scholar
  12. 12.
    Baer, P.G. and McGiff, J.C. Hormonal systems and renal hemodynamics. Ann Rev Physiol 42: 589–601, 1980.Google Scholar
  13. 13.
    Baylis, P.H. Osmoregulation and control of vasopressin secretion in healthy humans. Am J Physiol 253: R671 - R678, 1987.PubMedGoogle Scholar
  14. 14.
    Berl, T., Brautnar, N., Ben-David, N., Czaczkes, W. and Kleeman, C. Osmotic control of prolactin release and its effect on renal water excretion in man. Kidney International 10: 158–163, 1976.PubMedGoogle Scholar
  15. 15.
    Berl, T., Raz, A., Wald, H., Horowitz, J. and Czaczkes, W. Prostaglandin synthesis inhibition and the action of vasopressin: studies in man and rat. Am J Physiol 232 (6): F529 - F537, 1977.PubMedGoogle Scholar
  16. 16.
    Bie, P., Wang, C., Leadley, J.Jr. and Goetz, K. Hemodynamic and renal effects of low-dose infusions of atrial peptide in awake dogs. Am J Physiol 254: R161 - R169, 1988.PubMedGoogle Scholar
  17. 17.
    Bolger, P.M., Eisner, G.M., Ramwell, P.W. and Slotkoff, L.M. Effect of prostaglandin synthesis on renal function and renin in the dog. Nature 259: 244–245, 1976.PubMedGoogle Scholar
  18. 18.
    Bolger, P.M., Eisner, G.M., Ramwell, P.W., Slotkoff, L.M. and Corey, E.J. Renal actions of prostacyclin. Nature 271: 467–469, 1978.PubMedGoogle Scholar
  19. 19.
    Boling, E.A. and Lipkind, J.B. Body composition and serum electrolyte concentrations. J Appl Physiol 18 (5): 943–949, 1963.PubMedGoogle Scholar
  20. 20.
    Boudou, P., Fiet, J., Laureaux, C., Patricot, M.C., Guezennec, C.Y., Foglietti, M.J., Villette, J.M., Friemel, F. and Haag, J.C. Variations of a few plasmas and urinary components in marathon runners. Ann Biol Clin 45: 37–45, 1987.Google Scholar
  21. 21.
    Bozovic, L. and Castenfors, J. Effect of dihydralazine on plasma renin activity and renal function during supine exercise in normal subjects. Acta Physiol Scand 70: 281–289, 1967.PubMedGoogle Scholar
  22. 22.
    Bozovic, L., Castenfors, J. and Piscator, M. Effect of prolonged, heavy exercise on urinary protein excretion and plasma renin activity. Acta Physiol Scand 70: 143–146, 1967.Google Scholar
  23. 23.
    Brandenberger, G., Candas, V., Follenius, M., Libert, J.P. and Kahn, J.M. Vascular fluid shifts and endocrine responses to exercise in the heat. Eur J Applied Physiol 55: 123–129, 1986.Google Scholar
  24. 24.
    Buono, M.J. and Sjoholm, N.T. Effect of physical training on peripheral sweat production. J Appl Physiol 65 (2): 811–814, 1988.PubMedGoogle Scholar
  25. 25.
    Buono, M.J., Yeager, J.E. and Sucec, A.A. Effect of aerobic training on the plasma ACTH response to exercise. J Appl Physiol 63: 2499–2501, 1987.PubMedGoogle Scholar
  26. 26.
    Candas, V., Libert, J.P., Brandenberger, G., Sagot, J.C., Amoros, C. and Kahn, J.M. Hydration during exercise. Eur J Applied Physiol 55: 113–122, 1986.Google Scholar
  27. 27.
    Casten fors, J. Renal function during exercise. Acta Physiol Scand 70 (suppl. 293): 1–44, 1967.Google Scholar
  28. 28.
    Casten fors, J. Effect of ethacrynic acid on plasma renin activity during supine exercise in normal subjects. Acta Physiol Scand 70: 215–220, 1967.Google Scholar
  29. 29.
    Castenfors, J. Renal function during prolonged exercise. Ann NY Acad Sci 301: 151–159, 1978.Google Scholar
  30. 30.
    Chan, K., Pipe, A. and DeBold, A.J. Atrial natriuretic hormone in marathon running. Medicine and Science in Sports 20 (2): S39 - S39, 1988.Google Scholar
  31. 31.
    Claybaugh, J. and Share, L. Vasopressin, renin, and cardiovascular responses to continuous slow hemorrhage. Am J Physiol 24: 519–523, 1973.Google Scholar
  32. 32.
    Claybaugh, J.R., Pendergast, D.R., Davis, J.E., Akiba, C., Pazik, M. and Hong, S.K. Fluid conservation in athletes: responses to water intake, supine posture, and immersion. J Appl Physiol 61: 7–15, 1986.PubMedGoogle Scholar
  33. 33.
    Collins, K. and Weiner, J. Endocrinological aspects of exposure to high environmental temperatures. Physiol Rev 48: 785–859, 1968.PubMedGoogle Scholar
  34. 34.
    Collins, K.J. Action of exogenous aldosterone on the secretion and composition of drug-induced sweat. Clin Sci 30: 207–213, 1969.Google Scholar
  35. 35.
    Convertino, V.A., Brock, P.J., Keil, L.C., Bernauer, E.M. and Greenleaf, J.E. Exercise training-induced hypervolemia: role of plasma albumin, renin, and vasopressin. J Appl Physiol 48: 665–669, 1980.PubMedGoogle Scholar
  36. 36.
    Convertino, V.A., Greenleaf, J.E. and Bernauer, E.M. Role of thermal and exercise factors in the mechanism of hypervolemia. J Appl Physiol 48: 657–664, 1980.PubMedGoogle Scholar
  37. 37.
    Convertino, V.A., Keil, L.C. and Bernauer, E.M. Plasma volume, osmolality, vasopressin, and renin activity during graded exercise in man. J Appl Physiol 50: 123–128, 1981.PubMedGoogle Scholar
  38. 38.
    Convertino, V.A., Keil, L.C. and Greenleaf, J.E. Plasma volume, renin and vasopressin responses to graded exercise after training. J Appl Physiol 54: 508–514, 1983.PubMedGoogle Scholar
  39. 39.
    Costill, D.L. Water and electrolyte requirements during exercise. Clinics in Sports Medicine 3: 639–648, 1984.PubMedGoogle Scholar
  40. 40.
    Costill, D.L., Branam, G., Fink, W. and Nelson, R. Exercise induced sodium conservation: changes in plasma renin and aldosterone. Medicine and Science in Sports 8: 209–213, 1976.PubMedGoogle Scholar
  41. 41.
    Cuneo, R.C., Espiner, E.A., Nicholls, M.G., Yandle, T.G., Joyce, S.L. and Gilchrist, N.L. Renal, hemodynamic, and hormonal responses to atrial natriuretic peptide infusions in normal man, and effect of sodium intake. J Clin Endocrinol Metab 63: 946–953, 1986.PubMedGoogle Scholar
  42. 42.
    Cushner, H.M., Mulrow, J.P., Copley, J.B., Latham, R.L., Bailey, S. and Fried, T.A. Atrial natriuretic peptide (ANP) response to physiologic maneuvers in cardiac transplant patients. Kidney International 33: 259–259, 1988.Google Scholar
  43. 43.
    Decombaz, J., Reinhardt, P., Anantharaman, K. and Glutz, G.V. Biochemical changes in a 100 km run: free amino acids, urea, and creatinine. Eur J Applied Physiol 41: 61–72, 1979.Google Scholar
  44. 44.
    Demers, L.M., Harrison, T.S., Halbert, D.R. and Santen, R.J. Effect of prolonged exercise on plasma prostaglandin levels. Prostaglandins and Medicine 6: 413–418, 1981.PubMedGoogle Scholar
  45. 45.
    Denton, D.A. Salt appetite. In: Handbook of Physiology: Alimentary Canal. Food and Water Intake, edited by Washington, DC: American Physiology Society, 1967, p. 433–459.Google Scholar
  46. 46.
    DiBona, G.F. Neural mechanisms in body fluid homeostasis. Fed Proc 45: 2871–2877, 1986.PubMedGoogle Scholar
  47. 47.
    Dressendorfer, R.H., Wade, C.E. and Scaff, J.H. Renal function during short-term and prolonged strenuous exercise in coronary heart disease patients. J Cardiac Rehabil 3: 575–582, 1983.Google Scholar
  48. 48.
    Espiner, E.A., Nicholls, M.G., Yandle, T.G., Crozier, I.G., Cuneo, R.C., McCormick, D. and Ikram, H. Studies on the secretion, metabolism and action of atrial natriuretic peptide in man. J Hypertension 4 (Supplement 2): S85 - S91, 1986.Google Scholar
  49. 49.
    Fagard, R., Amery, A., Reybrouck, T., Lijnen, P., Moerman, E., Bogaert, M. and De Schaepdryver, A. Effects of angiotensin antagonism on hemodynamics, renin, and catecholamines during exercise. J Appl Physiol 43: 440–444, 1977.PubMedGoogle Scholar
  50. 50.
    Fagard, R., Grauwels, R., Groeseneken, D., Lijnen, P., Staessen, J., Vanhees, L. and Amery, A. Plasma levels of renin, angiotensin II, and 6-ketoprostaglandin Fla in endurance athletes. J Appl Physiol 59: 947–952, 1985.PubMedGoogle Scholar
  51. 51.
    Fagard, R., Lijnen, P. and Amery, A. Effects of angiotensin II on arterial pressure, renin and aldosterone during exercise. Eur J Applied Physiol 54: 254–261, 1985.Google Scholar
  52. 52.
    Fasciolo, J.C., Totel, G.L. and Johnson, R.E. Antidiuretic hormone and human eccrine sweating. J Appl Physiol 27: 303–307, 1969.PubMedGoogle Scholar
  53. 53.
    Fasola, A.F., Martz, B.L. and Helmer, O.M. Renin activity during supine exercise in normotensives and hypertensives. J Appl Physiol 21 (6): 1709–1712, 1966.PubMedGoogle Scholar
  54. 54.
    Fasola, A.F., Martz, B.L. and Helmer, O.M. Plasma renin activity during supine exercise in offspring of hypertensive parents. J Appl Physiol 25 (4): 410–415, 1968.Google Scholar
  55. 55.
    Fellman, N., Sagnol, M., Bedu, M., Falgairette, G., Van Praagh, E., Gaillard, G., Jouanel, P. and Coudert, J. Enzymatic and hormonal responses following a 24 h endurance run and a 10 h triathlon race. Eur J Applied Physiol 57: 545–553, 1988.Google Scholar
  56. 56.
    Follenius, M. and Brandenberger, G. Increase in atrial natriuretic peptide in response to physical exercise. Eur J Applied Physiol 57: 159–162, 1988.Google Scholar
  57. 57.
    Fortney, S.M., Vroman, N.B., Beckett, W.S., Permutt, S. and LaFrance, N.D. Effect of exercise hemoconcentration and hyperosmolality on exercise responses. J Appl Physiol 65 (2): 519–524, 1988.PubMedGoogle Scholar
  58. 58.
    Francesconi, R.P., Sawka, M.N., Pandolf, K.B., Hubbard, R.W., Young, A.J. and Muza, S. Plasma hormonal responses at graded hypohydration levels during exercise-heat stress. J Appl Physiol 59: 1855–1860, 1985.PubMedGoogle Scholar
  59. 59.
    Freund, B., Hashiro, G., Buono, M., Claybaugh, J. and Chrisney, S. Endocrine and electrolyte responses during and following a marathon in young versus middle aged runners. Medicine and Science in Sports 20(2):1988.Google Scholar
  60. 60.
    Freund, B.J., Claybaugh, J.R., Dice, M.S. and Hashiro, G.M. Hormonal and vascular fluid responses to maximal exercise in trained and untrained males. J Appl Physiol 63: 669–675, 1987.PubMedGoogle Scholar
  61. 61.
    Freund, B.J., Claybaugh, J.R., Hashiro, G.M. and Dice, M.S. Hormonal and renal responses to water drinking in moderately trained and untrained humans. Am J Physiol 254: R417 - R423, 1988.PubMedGoogle Scholar
  62. 62.
    Freund, B.J., Wade, C.E. and Claybaugh, J.R. Effects of exercise on atrial natriuretic factor: implications to fluid homeostasis. Sports Medicine 6: 364376, 1988.Google Scholar
  63. 63.
    Fyhrquist, F., Tikkanen, I., Toetterman, K.J., Hynynen, M., Tikkanen, T. and Andersson, S. Plasma atrial natriuretic peptide in health and disease. Eur Heart J 8 (Supplement B): 117–122, 1987.PubMedGoogle Scholar
  64. 64.
    Geelen, G., Keil, L.C., Kravik, S.E., Wade, C.E., Thrasher, T.N., Barnes, P.R., Pyka, G., Nesvig, C. and Greenleaf, J.E. Inhibition of plasma vasopressin after drinking in dehydrated humans. Am J Physiol 247: R968 - R971, 1984.PubMedGoogle Scholar
  65. 65.
    Geyssant, A., Geelen, G. and Denis, C.H. Plasma vasopressin, renin activity, and aldosterone: Effect of exercise training. Eur J Applied Physiol 6: 21–30, 1981.Google Scholar
  66. 66.
    Gibiniski, K., Kozbowski, S., Chwalbinska-Moneta, J., Giec, L., Zmudzinski, J. and Markiewicz, A. ADH and thermal sweating. Eur J Applied Physiol 42: 1–13, 1979.Google Scholar
  67. 67.
    Gleim, G.W., Zabetakis, P.M., DePasquale, E.E., Michelis, M.F. and Nicholas, J.A. Plasma osmolality, volume, and renin activity at the “anaerobic threshold”. J Appl Physiol 56: 57–63, 1984.PubMedGoogle Scholar
  68. 68.
    Goetz, K.L. Physiology and pathophysiology of atrial peptides. Am J Physiol 254: E1 - E15, 1988.PubMedGoogle Scholar
  69. 69.
    Greenleaf, J.E. and Sargent, F.H. Voluntary dehydration in man. J Appl Physiol 20 (4): 719–724, 1965.PubMedGoogle Scholar
  70. 70.
    Guezennec, C.Y., Defer, G., Cazorla, G., Sabathier, C. and Lhoste, F. Plasma renin activity, aldosterone and catecholamine levels when swimming and running. Eur J Applied Physiol 54: 632–637, 1986.Google Scholar
  71. 71.
    Hammer, M., Ladefoged, J. and Olgaard, K. Relationship between plamsa osmolality and plasma vasopressin in human subjects. Am J Physiol 238: E313 - E317, 1980.PubMedGoogle Scholar
  72. 72.
    Hellman, K. and Weiner, J. Antidiuretic substance in urine following exposure to high temperatures. J Appl Physiol 6: 194–198, 1953.Google Scholar
  73. 73.
    Hespel, P., Lijnen, P., Vanhees, L., Fagard, R. and Amery, A. Beta-adrenoceptors and the regulation of blood pressure and plasma renin during exercise. J Appl Physiol 60: 108–113, 1986.PubMedGoogle Scholar
  74. 74.
    Hinghofer-Szalkay, H., Kravik, S.E. and Greenleaf, J.E. Effect of lower-body positive pressure on postural fluid shifts in men. Eur J Applied Physiol 57: 49–54, 1988.Google Scholar
  75. 75.
    Hodsman, G.P., Phillips, P.A., Ogawa, K. and Johnston, C.I. Atrial natriuretic factor in normal man: effects of tilt, posture, exercise and haemorrhage. J Hypertension 4 (Supplement 6): S502 - S505, 1986.Google Scholar
  76. 76.
    Hubbard, R.W., Sandick, B.L., Matthew, W.T., Francesconi, R., Sampson, J.B., Durkot, M.J., Mailer, O. and Engell, D.B. Voluntary dehydration and alliesthesia for water. J Appl Physiol 57: 868–875, 1984.PubMedGoogle Scholar
  77. 77.
    Itoh, H., Nakao, K., Katsuura, G., Morii, N., Shino, S., Yamada, T., Sugawara, A., Saito, YI, Watanabe, K., Igano, K., Inouye, K. and Imura, H. Atrial natriuretic polypeptides: structure-activity relationship in the central action–a comparison of their antidipsogenic actions. Neuroscience Letters 74: 102–106, 1987.PubMedGoogle Scholar
  78. 78.
    Januszewicz, P., Gutkowska, J., Thibault, G., Garcia, R., Mercure, C., Jolicoeur, F., Genest, J. and Cantin, M. Dehydration-induced changes in the secretion of atrial natriuretic factor in Brattleboro rats: effect of water-drinking. Neuroscience Letters 67: 203–207, 1986.PubMedGoogle Scholar
  79. 79.
    Januszewicz, P., Thibault, G., Gutkowska, J., Garcia, R., Mercure, C., Jolicoeur, F., Genest, J. and Cantin, M. Atrial natriuretic factor and vasopressin during dehydration and rehydration in rats. Am J Physiol 251: E497 - E501, 1986.PubMedGoogle Scholar
  80. 80.
    Johansson, G., Uusitupa, M., Haerkoenen, M., Siitonen, O., Aro, A. and Korhonen, T. Hormonal effects of beta-receptor blockade during exercise. Acta Endocrinol 104: 10–14, 1983.PubMedGoogle Scholar
  81. 81.
    Kachadorian, W.A. and Johnson, R.E. Renal responses to various rates of exercise. J Appl Physiol 28: 748–752, 1970.PubMedGoogle Scholar
  82. 82.
    Kachadorian, W.A. and Johnson, R.E. The effect of exercise on some clinical measures of renal function. Am Heart J 82: 278–280, 1971.PubMedGoogle Scholar
  83. 83.
    Katsuura, G., Nakamura, M., Inouye, K., Kono, M., Nakao, K. and Imura, H. Regulatory role of atrial natriuretic polypeptide in water drinking in rats. European J. Pharmacol. 121: 285–287, 1986.Google Scholar
  84. 84.
    Keeler, R. and Wilson, N. Vasopressin contamination as a cause of some apparent renal actions of prolactin. Can. J. Physiol. Pharmacol. 54: 887–890, 1976.Google Scholar
  85. 85.
    Keller, N., Moller, T., Sykulski, R., Storm, T.L. and Thamsborg, G.M. Effect of alpha-1 adrenoreceptor blockade on plasma levels of atrial natriuretic peptide during dynamic exercise in normal man. Horm Metabol Res 19: 344–344, 1987.Google Scholar
  86. 86.
    Keul, J., Kohler, B., Von Glutz, G., Luethi, U., Berg, A. and Howald, H. Biochemical changes in a 100 km run: carbohydrates, lipids, and hormones in serum. Eur J Applied Physiol 47: 181–189, 1981.Google Scholar
  87. 87.
    Kirby, C.R. and Convertino, V.A. Plasma aldosterone and sweat sodium concentrations after exercise and heat acclimation. J Appl Physiol 61: 967–970, 1986.PubMedGoogle Scholar
  88. 88.
    Kiyonaga, A., Arakawa, K., Tanaka, H. and Shindo, M. Blood pressure and hormonal responses to aerobic exercise. Hypertension 7: 125–131, 1985.PubMedGoogle Scholar
  89. 89.
    Kjaer, M., Bangsbo, J., Lortie, G. and Galbo, H. Hormonal response to exercise in humans: influence of hypoxia and physical training. Am J Physiol 254: R197 - R203, 1988.PubMedGoogle Scholar
  90. 90.
    Knochel, J., Dotin, L. and Hamburger, R. Pathophysiology of intense physical conditioning in a hot climate. I. Mechanisms of potassium depletion. J Clin Invest 51: 242–255, 1972.PubMedGoogle Scholar
  91. 91.
    Kosunen, K. and Pakarinen, A. Plasma renin, angiotensin II, and plasma and urinary aldosterone in running exercise. J Appl Physiol 41: 26–29, 1976.PubMedGoogle Scholar
  92. 92.
    Kosunen, K., Pakarinen, A., Kuoppasalmi, K., Naveri, H., Rehunen, S., Standerskjold-Nordenstam, C.G., Harkonen, M. and Aldercreutz, H. Cardiovascular function and the renin-angiotensin-aldosterone system in long-distance runners during various training periods. Scand J Clin Lab Invest 40: 429–435, 1980.PubMedGoogle Scholar
  93. 93.
    Kotchen, T., Hartley, L., Rice, T.W., Mougey, E., Jones, L. and Mason, J. Renin, norepinephrine and epinephrine responses to graded exercise. J Appl Physiol 31: 178–184, 1975.Google Scholar
  94. 94.
    Kozlowski, S. and Saltin, B. Effect of sweat loss on body fluids. J Appl Physiol 19: 1119–1124, 1964.PubMedGoogle Scholar
  95. 95.
    Kurosawa, T., Sakamoto, H., Katoh, Y. and Marumo, F. Atrial natriuretic peptide is only a minor diuretic factor in dehydrated subjects immersed to the neck in water. Eur J Applied Physiol 57: 10–14, 1988.Google Scholar
  96. 96.
    Lassiter, W.E., Gottschalk, C.W. and Mylle, M. Micropuncture study of net transtubular movement of water and urea in nondiuretic mammalian kidney. Am J Physiol 200: 1139–1146, 1961.PubMedGoogle Scholar
  97. 97.
    Leenen, F.H., Boer, P. and Geyskes, G.G. Sodium intake and the effects of isoproterenol and exercise on plasma renin in man. J Appl Physiol 45: 870–874, 1978.PubMedGoogle Scholar
  98. 98.
    Levinsky, N., Davidson, D.G. and Berliner, R.W. Effects of reduced glomerular filtration on urine concentration in the presence of antidiuretic hormone. Am J Physiol 196: 451–456, 1959.PubMedGoogle Scholar
  99. 99.
    Levinsky, N.G. and Berliner, R.W. The role of urea in the urine concentrating mechanism. J Clin Invest 38: 741–748, 1959.PubMedGoogle Scholar
  100. 100.
    Levinsky, N.G., Davidson, D.G. and Berliner, R.W. Effects of reduced glomerular filtration on urine concentration in the presence of antidiuretic hormone. J Clin Invest 38: 730–740, 1959.PubMedGoogle Scholar
  101. 101.
    Lijnen, P., Hespel, P., Eynde, E.V. and Amery, A. Urinary excretion of electrolytes during prolonged physical activity in normal man. Eur J Applied Physiol 53: 317–321, 1985.Google Scholar
  102. 102.
    M’Buyamba-Kabangu, J., Fagard, R., Lijnen, P. and Amery, A. Relationship between plasma renin activity and physical fitness in normal subjects. Eur J Applied Physiol 53: 304–307, 1985.Google Scholar
  103. 103.
    Maher, J.T., Jones, L.G., Hartley, H., Williams, G.H. and Rose, L.I. Aldosterone dynamics during graded exercise at sea level and high altitude. J Appl Physiol 39: 18–22, 1975.PubMedGoogle Scholar
  104. 104.
    Manhem, P. and Hoek felt, B. Prolonged clonidine treatment: catecholamines, renin activity and aldosterone following exercise in hypertensives. Acta Med Scand 209: 253–260, 1981.PubMedGoogle Scholar
  105. 105.
    Maresh, C.M., Wang, B.C. and Goetz, K.L. Plasma vasopressin, renin activity, and aldosterone responses to maximal exercise in active college females. Eur J Applied Physiol 54: 398–403, 1985.Google Scholar
  106. 106.
    Masotto, C. and Negro-Vilar, A. Inhibition of spontaneous or angiotensin II-stimulated water intake by atrial natriuretic factor. Brain Res Bull 15: 523–526, 1985.PubMedGoogle Scholar
  107. 107.
    Matsubara, H., Nishikawa, M., Umeda, Y., Taniguchi, T., Iwasaka, T., Kurimoto, T., Yamane, Y. and Inada, M. The role of atrial pressure in secreting atrial natriuretic polypeptides. Am Heart J 113: 1457–1462, 1987.PubMedGoogle Scholar
  108. 108.
    Meehan, R.T. Renin, aldosterone, and vasopressin responses to hypoxia during 6 hours of mild exercise. Aviat Space Environ Med 57: 960–965, 1986.PubMedGoogle Scholar
  109. 109.
    Meirleir, K.D., Naaktgeboren, N., Steirteghem, A.V., Gorus, F., Olbrecht, J. and Block, P. Beta-endorphin and ACTH levels in peripheral blood during and after aerobic and anaerobic exercise. Eur J Applied Physiol 55: 5–8, 1986.Google Scholar
  110. 110.
    Melin, B., Eclache, J.P. and Geelen, G. Plasma AVP, neurophysin, renin activity, and aldosterone during submaximal exercise performed until exhaustion in trained and untrained men. Eur J Applied Physiol 44: 141–151, 1980.Google Scholar
  111. 111.
    Mitchell, J.W., Nadel, E.R. and Stolwijk, J.A. Respiratory weight losses during exercise. J Appl Physiol 32 (4): 474–476, 1972.PubMedGoogle Scholar
  112. 112.
    Morris, D.J. The Metabolism and Mechanism of Action of Aldosterone. Endocrine Reviews 20: 234–247, 1981.Google Scholar
  113. 113.
    Mueller, F.B., Erne, P., Raine, A.E., Bolli, P., Linder, L., Resink, Ti., Cottier, C. and Buhler, F.R. Atrial antipressor natriuretic peptide: release mechanisms and vascular action in man. J Hypertension 4 (Supplement 2): S109 - S114, 1986.Google Scholar
  114. 114.
    Myhre, L.G., Hartung, G.H. and Tucker, D.M. Plasma volume and blood metabolites in middle-aged runners during a warm-weather marathon. Eur J Applied Physiol 48: 227–240, 1982.Google Scholar
  115. 115.
    Nadel, E.R., Pandolf, K.B., Roberts, M.R. and Stolwijk, J.A. Mechanism of thermal acclimitization to exercise and heat. J Appl Physiol 37: 515–520, 1974.PubMedGoogle Scholar
  116. 116.
    Nishikimi, T., Kohno, M., Matsuura, T., Akioka, K., Teragaki, M., Yasuda, M., Oku, H., Takeuchi, K. and Takeda, T. Effect of exercise on circulating atrial natriuretic polypeptide in valvular heart disease. American Journal of Cardiology 58: 1119–1120, 1986.PubMedGoogle Scholar
  117. 117.
    Nishikimi, T., Kohno, M., Matsuura, T., Kanayama, Y., Kaname, A., Teragaki, M., Yasuda, M., Oku, H., Takeuchi, K. and Takeda, T. Circulating atrial natriuretic polypeptide during exercise in patients with essential hypertension. J Hypertension 4 (Supplement 6): S546 - S549, 1986.Google Scholar
  118. 118.
    Nose, H., Mack, G.W., Shi, X. and Nadel, E.R. Involvement of sodium retention hormones during rehydration in humans. J Appl Physiol 65 (1): 332–336, 1988.PubMedGoogle Scholar
  119. 119.
    Nose, H., Mack, G.W., Shi, X. and Nadel, E.R. Role of osmolality and plasma volume during rehydration in humans. J Appl Physiol 65 (1): 325–331, 1988.PubMedGoogle Scholar
  120. 120.
    Nose, H., Mack, G.W., Shi, X. and Nadel, E.R. Shift in body fluid compartments after dehydration in humans. J Appl Physiol 65 (1): 318–324, 1988.PubMedGoogle Scholar
  121. 121.
    Ochwadt, B. Relation of renal blood supply to diuresis. Prog Cardiovasc Dis 3: 501–510, 1961.PubMedGoogle Scholar
  122. 122.
    Ogawa, K., Smith, A.I., Hodsman, G.P., Jackson, B., Woodcock, E.A. and Johnston, C.I. Plasma atrial natriuretic peptide: concentrations and circulating forms in normal man and patients with chronic renal failure. Clin Exp Pharm Physiol 14: 95–102, 1987.Google Scholar
  123. 123.
    Olsson, K.E. and Saltin, B. Variation in total body water with muscle glycogen changes in man. Acta Physiol Scand 80: 11–18, 1970.PubMedGoogle Scholar
  124. 124.
    Opstad, P.K., Oktedalen, O., Aakvaag, A., Fonnum, F. and Lund, P.K. Plasma renin activity and serum aldosterone during prolonged physical strain. Eur J Applied Physiol 54: 1–6, 1985.Google Scholar
  125. 125.
    Pedersen, E.B., Kornerup, H.J. and Larsen, J.J. Responsiveness of the renin-aldosterone system during exercise in young patients with essential hypertension. Eur J Clin Invest 11: 403–408, 1981.PubMedGoogle Scholar
  126. 126.
    Petzl, D.H., Hartter, E., Osterode, W., Boehm, H. and Woloszczuk, W. Atrial natriuretic peptide release due to physical exercise in healthy persons and in cardiac patients. Klin Wochenschr 65: 194–196, 1987.PubMedGoogle Scholar
  127. 127.
    Poortmans, J.R. Effect of exercise on the renal clearance of amylase and lysozyme in humans. Clin Sci 43: 115–120, 1972.PubMedGoogle Scholar
  128. 128.
    Poortmans, J.R. Exercise and renal function. Exercise and Sports Science Reviews 5: 255–294, 1977.Google Scholar
  129. 129.
    Poortmans, J.R. Exercise and renal function. Sports Medicine 1: 125–153, 1984.PubMedGoogle Scholar
  130. 130.
    Raine, A.E., Phil, D., Erne, P., Burgisser, E., Muller, F.B., Bolli, PI, Burkart, F. and Buhler, F.R. Atrial natriuretic peptide and atrial pressure in patients with congestive heart failure. N Engl J Med 315: 533–537, 1986.PubMedGoogle Scholar
  131. 131.
    Raisz, L.G., Au, W.Y. and Scheer, R.L. Studies on the renal concentrating mechanism. III. Effect of heavy exercise. J Clin Invest 39: 8–13, 1959.Google Scholar
  132. 132.
    Ramsey, D., Keil, L., Sharpe, M. and Shinsako, J. Angiotensin II infusion increases vasopressin, ACTH, and il-hydroxycorticosteroid secretion. Am J Physiol 234: R66 - R71, 1978.Google Scholar
  133. 133.
    Refsum, H.E. and Stromme, S.B. Relationship between urine flow, glomerular filtration, and urine solute concentrations during prolonged heavy exercise. Scand J Clin Lab Invest 35: 775–780, 1975.PubMedGoogle Scholar
  134. 134.
    Refsum, H.E. and Stromme, S.B. Renal osmol clearance during prolonged heavy exercise. Scand J Clin Lab Invest 38: 19–22, 1977.Google Scholar
  135. 135.
    Reid, I.A. Actions of angiotensin II on the brain: mechanisms and physiologic role. Am J Physiol 246: F533 - F543, 1984.PubMedGoogle Scholar
  136. 136.
    Reid, I.A. and Ganong, W.F. Control of aldosterone secretion. In: Hypertension: Pathophysiology and Treatment, edited by Genest, J., Koiw, E. and Kuchel, O. New York: McGraw-Hill, 1977, p. 265–292.Google Scholar
  137. 137.
    Robertson, G.L., Mahr, E.A., Athar, S. and Sinha, T. Development and clinical application of a new method for the radioimmunoassay of arginine vasopressin in human plasma. J Clin Invest 52: 2340–2352, 1973.PubMedGoogle Scholar
  138. 138.
    Rolls, B.J., Wood, R.J., Rolls, E.T., Lind, H., Lind, W. and Ledingham, J.G. Thirst following water deprivation in humans. Am J Physiol 239: R476 - R482, 1980.PubMedGoogle Scholar
  139. 139.
    Rowell, L.B. Human cardiovascular adjustments to exercise and thermal stress. Physiol Rev 54: 75–159, 1974.PubMedGoogle Scholar
  140. 140.
    Rydin, H. and Verney, E.B. The inhibition of water diuresis by emotional stress and by muscular exercise. Q J Exp Physiol 27: 343–374, 1938.Google Scholar
  141. 141.
    Sagnella, G.A., Markandu, N.D., Shore, A.C. and MacGregor, G.A. Changes in plasma immunoreactive atrial natriuretic peptide in response to saline infusion or to alterations in dietary sodium intake in normal subjects. J Hypertension 4 (Supplement 2): S115 - S118, 1986.Google Scholar
  142. 142.
    Saito, Y., Nakao, K., Sugawara, A., Nishimura, K., Sakamoto, M., Narito, M., Yamada, T., Itoh, H., Shiono, S., Kuriyama, T., Hirai, M., Ohi, M., Toshihiko, B. and Imura, H. Atrial natriuretic polypeptide during exercise in healthy man. Acta Endocrinologica (Copenh) 116: 59–65, 1987.Google Scholar
  143. 143.
    Saltin, B. Aerobic work capacity and circulation at exercise in man. Acta Physiol Scand 62 (Supplement 230): 1–52, 1964.Google Scholar
  144. 144.
    Schlein, E.M., Spooner, G.R., Day, C., Pickering, M. and Cade, R. Extrarenal water loss and antidiuretic hormone. J Appl Physiol 31 (4): 569–572, 1971.PubMedGoogle Scholar
  145. 145.
    Schrier, R.W., Berl, T. and Anderson, R.J. Osmotic and nonosmotic control of vasopressin release. Am J Physiol 236: F321 - F332, 1979.PubMedGoogle Scholar
  146. 146.
    Schrier, R.W., Keller, H.I., Gilliland, P.F. and Teschan, P.E. Renal, metabolic, and circulatory responses to heat and exercise. Ann Intern Med 73: 213–223, 1970.PubMedGoogle Scholar
  147. 147.
    Shangold, M.M., Gatz, M.L. and Thysen, B. Acute effects of exercise on plasma concentrations of prolactin and testosterone in recreational women runners. Fertility and Sterility 35: 699–702, 1981.PubMedGoogle Scholar
  148. 148.
    Share, L. Blood pressure, blood volume, and the release of vasopressin. In: Handbook of Physiology,edited by Knobil, E. and Sawyer, W. Washington, DC: American Physiological Society, 1974, p. 243–252.Google Scholar
  149. 149.
    Share, L. and Claybaugh, J. Regulation of body fluids. Ann Rev Physiol 34: 235–260, 1972.Google Scholar
  150. 150.
    Somers, V.K., Anderson, J.V., Conway, J., Sleight, P. and Bloom, S.R. Atrial natriuretic peptide is released by dynamic exercise in man. Horm Metabol Res 18: 871–872, 1986.Google Scholar
  151. 151.
    Staessen, J., Fagard, R., Hespel, P., Lijnen, P., Vanhees, L. and Amery, A. Plasma renin system during exercise in normal men. J Appl Physiol 63: 188–194, 1987.PubMedGoogle Scholar
  152. 152.
    Stevenson, J.A. Central mechanisms controlling water intake. In: Handbook of Physiology: Alimentary Canal. Food and Water Intake, edited by Washington,DC: American Physiology Society, 1967, p. 173–187.Google Scholar
  153. 153.
    Stricker, E.M. and Verbalis, J.G. Hormones and behavior: the biology of thirst and sodium appetite. Am. Scientist 76: 261–267, 1988.Google Scholar
  154. 154.
    Svedenhag, J. The sympatho-adrenal system in physical conditioning. Acta Physiol Scand 125 (Supplement 543): 3–73, 1985.Google Scholar
  155. 155.
    Tanaka, H., Shindo, M., Gutkowska, J., Kinoshita, A., Urata, H., Ikeda, M. and Arakawa, K. Effect of acute exercise on plasma immunoreactive–atrial natriuretic factor. Life Sciences 39: 1685–1693, 1986.PubMedGoogle Scholar
  156. 156.
    Thamsborg, G., Storm, T., Keller, N., Sykulski, R. and Larsen, J. Changes in plasma atrial natriuretic peptide during exercise in healthy volunteers. Acta Med Scand 221: 441–444, 1987.PubMedGoogle Scholar
  157. 157.
    Thamsborg, G., Sykulski, R., Larsen, J., Storm, T. and Keller, N. Effect of Beta-1 adrenoreceptor blockade on plasma levels of atrial natriuretic peptide during exercise in normal man. Clin Physiol 7: 313–318, 1987.PubMedGoogle Scholar
  158. 158.
    Thrasher, T.N., Nistal-Herrera, J.F., Keil, L.C. and Ramsay, D.J. Satiety and inhibition of vasopressin secretion after drinking in dehydrated dogs. Am J Physiol 240: E394 - E401, 1981.PubMedGoogle Scholar
  159. 159.
    Thrasher, T.N., Wade, C.E., Keil, L.C. and Ramsay, D.J. Sodium balance and aldosterone during dehydration and rehydration in the dog. Am J Physiol 247: R76 - R83, 1984.PubMedGoogle Scholar
  160. 160.
    Toth, E., Stelfox, J. and Kaufman, S. Cardiac control of salt appetite. Am J Physiol 252: R925 - R929, 1987.PubMedGoogle Scholar
  161. 161.
    Ullrich, K.J., Kramer, K. and Boylan, J.W. Present knowledge of the counter-current system in the mammalian kidney. Prog Cardiovasc Dis 3: 395–431, 1961.PubMedGoogle Scholar
  162. 162.
    Verde, T., Shephard, J., Corey, P. and Moore, R. Sweat composition in exercise and in heat; J Appl Physiol 53: 1540–1545, 1982.PubMedGoogle Scholar
  163. 163.
    Virvidakis, C., Loukas, A., Symvoulidou, D.M. and Mountokalakis, T. Renal responses to bicycle exercise in trained athletes: influence of exercise intensity. Int J Sports Med 7: 86–88, 1986.PubMedGoogle Scholar
  164. 164.
    Vlcek, J., Stemberk, V. and Koupil, P. Renal excretion of amino acids at submaximum exertion. Cas Lek ces 126: 147–149, 1987.Google Scholar
  165. 165.
    Wade, C.E. Response, regulation, and actions of vasopressin during exercise: a review. Medicine and Science in Sports and Exercise 16: 506–511, 1984.PubMedGoogle Scholar
  166. 166.
    Wade, C.E. and Claybaugh, J. Plasma renin activity, vasopressin concentration, and urinary excretory responses to exercise in men. J Appl Physiol 49: 930–936, 1980.PubMedGoogle Scholar
  167. 167.
    Wade, C.E., Dressendorfer, R.H., O’Brien, J.C. and Claybaugh, J.R. Renal function, aldosterone, and vasopressin excretion following repeated long distance running. J Appl Physiol 50: 709–712, 1981.PubMedGoogle Scholar
  168. 168.
    Wade, C.E., Hill, L.C., Hunt, M.M. and Dressendorfer, R.H. Plasma aldosterone and renal function in runners during a 20-day road race. Eur J Applied Physiol 54: 456–460, 1985.Google Scholar
  169. 169.
    Wade, C.E., Ramee, S.R., Hunt, M.M. and White, C.J. Hormonal and renal responses to converting enzyme inhibition during maximal exercise. J Appl Physiol 63: 1796–1800, 1987.PubMedGoogle Scholar
  170. 170.
    Walsh, K.P., Williams, T.D.M., Pitts, S.E., Lightman, S.L. and Sutton, R. Role of atrial pressure and rate release of atrial natriuretic peptide. Am J Physiol 254: R607 - R610, 1988.PubMedGoogle Scholar
  171. 171.
    Wardener, D. and Hugh, E. The control of sodium excretion. Am J Physiol 235: F163 - F173, 1978.PubMedGoogle Scholar
  172. 172.
    Weitzman, R. and Kleeman, C.R. Water metabolism and neurohypophyseal hormones. In: Clinical Disorders of Fluid and Electrolyte Metabolism,edited by Maxwell, M.H. and Kleeman, C.R. New York: McGraw-Hill Book Co., 1980, p. 531–645.Google Scholar
  173. 173.
    Wilkerson, J., Gutin, B. and Horvath, S.M. Exercise-induced changes in blood, red cell, and plasma volumes in man. Med Sci Sports 9: 155–158, 1977.PubMedGoogle Scholar
  174. 174.
    Wilkerson, J.E., Horvath, S.M., Gutin, B., Molnar, S. and Diaz, F.J. Plasma electrolyte content and concentration during treadmill exercise in humans. J Appl Physiol 53: 1529–1539, 1982.PubMedGoogle Scholar
  175. 175.
    Wolf, J.P., Nguyen, N.U., Dumoulin, G. and Berthelay, S. Plasma renin and aldosterone changes during twenty minutes’ moderate exercise. Eur J Applied Physiol 54: 602–607, 1986.Google Scholar
  176. 176.
    Wyndham, C., Benade, A., Williams, C., Strydon, N., Goldin, A. and Heyns, A. Changes in central circulation and body fluid spaces during acclimatization to heat. J Appl Physiol 25: 586–593, 1968.PubMedGoogle Scholar
  177. 177.
    Zambraski, E. and Dunn, M. Renal prostaglandin (PG) secretion and excretion in exercising dogs. Fed Proc 38: 893–893, 1979.Google Scholar
  178. 178.
    Zambraski, E., Rofrano, T. and Ciccone, C. Effects of aspirin treatment on kidney function in exercising man. Med Sci Sports Exerc 14: 419–423, 1982.PubMedGoogle Scholar
  179. 179.
    Zambraski, E.J., Tucker, M.S., Lakas, C.S., Grassi, S.M. and Scanes, C.G. Mechanism of renin release in exercising dog. Am J Physiol 246: E71 - E76, 1984.PubMedGoogle Scholar

Copyright information

© Plenum Press, New York 1989

Authors and Affiliations

  • Charles E. Wade
    • 1
  • Beau J. Freund
    • 2
  • John R. Claybaugh
    • 2
  1. 1.Division of Military Trauma ResearchLetterman Army Institute of ResearchPresidio of San FranciscoUSA
  2. 2.Department of Clinical InvestigationTripler Army Medical Center, TAMCUSA

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