Abstract
Structural and functional plasticity of central terminals of primary sensory neurons is regulated by nerve growth factor supplied by retrograde axoplasmic transport to dorsal root ganglion cells. Two important aspects of this regulatory system: transganglionic degenerative atrophy and regenerative synaptoneogenesis are reviewed in view of electron microscopic histochemical and immunocytochemical studies.
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Aldskogius, H., Cerne, H., and Holmberg, A., 1985a, The effect of sciatic nerve transection on myelinated fibers in the L5 dorsal root and lumbar dorsal column. A Marchi study in the rat, Anat. Embryol., 171:181
Aldskogius, H., Arvidsson, J., and Grant, G., 1985b, The reaction of primary sensory neurons to peripheral nerve injury with particular emphasis on transganglionic changes, Brain Res. Rev., 10:27
Aldskogius, H., and Risling, M., 1983, Preferential loss of unmyelinated axons in the L7 dorsal root of kittens following sciatic neurectomy, Brain Res., 289:358
Arvidsson, J., and Grant, G., 1979, Further observations on transganglionic degeneration in trigeminal primary sensory neurons, Brain Res., 162:1
Arvidsson, J., 1979, An ultrastructural study of transganglionic degeneration in the main sensory trigeminal nucleus of the rat, J. Neurocytol., 8:31
Barber, R. P., Vaughn, J. E., Slemmon, J. R., Salvaterra, P. M., Robert, P. M., and Leeman, S. E., 1979, The origin, distribution and synaptic relationships of substance P axons in rat spinal cord, J. Comp. Neurol., 184:331
Barbut, D., Polak, J. M., and Wall, P. D., 1981, Substance P in spinal cord dorsal horn decreases following peripheral nerve injury, Brain Res., 205:289
Bernstein, J. J., and Bernstein, M. E., 1971, Axonal regeneration and formation of synapses proximal to the side of lesion following hemisection of the rat spinal cord, Exp. Neurol., 30:336
Bezzegh, A., Knyihár-Csillik, E., Boti, Zs., Tajti, J., Zaborski, Z., and Csillik, B., 1986, A computer-aided analysis of the effect of peripheral nerve transection on TMPase activity of substantia gelatinosa Rolandi, Z. mikrosk.-anat. Forsch., 100:428
Black, I. B., Adler, J. E., Dreyfus, C. F., et al, 1984, Neurotransmitter plasticity at the molecular level, Science, 225:1266
Burnstock, G., 1978, A basis for distinguishing two types of purinergic receptor, in: “Cell membrane receptors for drugs and hormones: a multidisciplinary approach,” L. Bolis and R. W. Straub, eds., Raven Press, New York: 107
Cajal, S. R. y, 1918, Degeneration and regeneration of the nervous system, University Press, Oxford: 750
Csillik, B., and Knyihár, E., 1975, Degenerative atrophy and regenerative proliferation in the rat spinal cord, Z. mikrosk.-anat. Forsch., 89:1099–1103
Csillik, B., and Knyihár, E., 1976, “New” features of the trophical entity, in: “Neuron concept today,” J. Szentágothal and J. Hamori, eds., Tihany: 27
Csillik, B., Knyihár, E., and Elshiekh, A. A., 1977a, Degenerative atrophy of central terminals of primary sensory neurons induced by blockade of axoplasmic transport in peripheral nerves, Experientia (Basel), 33:656
Csillik, B., and Knyihár, E., 1977b, Histochemistry of synapses, Cell Mol. Biol., 22:285–292
Csillik, B., 1980, Infrastructure of the neuron, in: “Neurotransmitters. Comparative aspects,” J. Salanki and T. M. Turpaev, eds., Akadémiai Kiadó: 149
Csillik, B., and Knyihár, E., 1978a, Biodynamic plasticity in the Rolando substance, Progr. Neurobiol., 10:202
Csillik, B., Knyihár, E., Jojart, I., Elshiek, A. A., and Pór, I., 1978b, Perineural microtubule inhibitors induce degenerative atrophy of central nociceptive terminals in the Rolando substance, Res. Comm. Chem. Path. Pharm., 21:467
Csillik, B., Knyihár, E., and Rakic, P., 1982, Transganglionic degenerative atrophy and regenerative proliferation in the Rolando substance of the primate spinal cord: discoupling and restoration of synaptic connectivity in the central nervous system after peripheral lesions, Folia Morph., 30:189
Csillik, B., and Knyihár-Csillik, E., 1981a, The spinal projection area of primary nociceptive afferents: Regenerative synaptoneogenesis in the Rolando substance, in: “Adv. Physiol. Sci., Vol. 36,” O. Feher and F. Joo, eds., Akadémiai Kiadó: 47
Csillik, B., and Knyihár-Csillik, E., 1981b, Reactions of the substantia gelatinosa Rolandi to injury of peripheral sensory axons, in: “Spinal cord sensation,” A. G. Brown and M. Réthelyi, eds., Scottish Academic Press, Edinburgh: 309
Csillik, B., and Knyihár-Csillik, E., 1981c, Regenerative synaptoneogenesis in the mammalian spinal cord: Dynamics of synaptochemical restoration in the Rolando substance after transganglionic degenerative atrophy, J. Neural Transmiss., 52:303
Csillik, B., Knyihár-Csillik, E., and Tajti, J., 1982a, Blockade of retrograde axoplasmic transport induces tranganglionic degenerative atrophy of central terminals of primary nociceptive neurons, Acta Biol. Acad. Sci. Hung., 33:149
Csillik, B., and Knyihár-Csillik, E., 1982b, Reversibility of microtubule inhibitor-induced transganglionic degenerative atrophy of central terminals of primary nociceptive neurons, Neuroscience, 7:1149
Csillik, B., Schwab, M. E., and Thoenen, H., 1983, Transganglionic regulation by nerve growth factor of the primary nociceptive analyzer, Neurosci. Lett. Suppl., 14:79
Csillik, B., Knyihár-Csillik, E., Bezzegh, A., Kiss, J., Léránth, Cs., Pór, I., and Záborszky, Z., 1984a, Transganglionic degenerative atrophy of central terminals of primary sensory neurons after perineural application of vinblastin: decay of dorsal root potential and depletion of neuropeptides, in: “Antidromic vasodilatation and neurogenic inflammation”, L. A. Chahl, J. Szolcsanyi, and F. Lembeck, eds., Akadémiai Kiadó, Budapest: 141
Csillik, B., 1984b, Nerve growth factor regulates central terminals of primary sensory neurons, Z. mikr.- anat. Forsch., 98:11
Csillik, B., KnyihárCsillik, E., Pór, I., et al., 1984c, Role of nerve growth factor (NGF) in structural and functional regulation of the primary nociceptive analyzer, Acta Physiol. Hung., 63:311
Csillik, B., and Knyihár-Csillik, E., 1986, “The protean gate. Structure and plasticity of the primary nociceptive analyzer,” Akadámiai Kiadó
Csillik, B., Schwab, M. E., and Thoenen, H., 1985a, Transganglionic regulation of central terminals of dorsal root ganglion cells by nerve growth factor (NGF), Brain Res., 331:11
Csillik, B., Kovacs, K., Penke, B., Tajti, J., and Szilard, J., 1985b, Transganglionic effect of basic peptides on the primary nociceptive analyzer, in: “Receptors and centrally acting drugs,” E. S. Vizi, S. Fürst, and G. Zsilla, eds., Proc. 4th Congr. Hung. Pharmacol. Soc.,Vol. 2, Budapest
Csillik, B., Knyihár-Csillik, E., and Bezzegh, A., 1986, Comparative electron histochemistry of thiamine monophosphatase and substance P in the upper dorsal horn, Acta histochem., 80:125
Cuello, A. C., 1987, Peptides as neurormodulators in primary sensory neurons, Neuropharmacol., 26:971
Devor, M., and Claman, D., 1980, Mapping and plasticity of acid phosphatase afferents in the rat dorsal horn, Brain Res., 190:17
Dreyfus, P. M., 1985, The neurochemistry of vitamin deficiencies. — Thiamin, in: “Handbook of neurochemistry, Vol. 10,”A. Lajtha, ed., Plenum Press, New York: 759
Ferencsik, M., 1986, Dynamism of tranganglionic degenerative atrophy following crush injury to the peripheral nerve, Z. mikrosk. -anat. Forsch., 100:490
Fischer, J., and Csillik, B., 1985, Lectin binding: a genuine marker for transganglionic regulation of human primary sensory neurons, Neurosci. Lett., 54:263
Fischer, J., Klein, P. J., and Csillik, B., 1985, Ulex Europaeus Ilectin-binding glycoprotein in primary sensory terminals of human spinal cord, in:“Lectins, Vol. 4,” T. C. Bog-Hansen and J. Breborowicz, eds., Walter de Gruyter and Co., Berlin-New York: 117
Fitzgerald, M., and Swett, J., 1983, The termination pattern of sciatic nerve afferents in the substantia gelatinosa of neonatal rats, Neurosci. Lett., 43:149
Fitzgerald, M., Woolf, C. J., Gibson, S. J., and Mallaburn, P. S., 1984, Alterations in the structure, function and chemistry of C fibres following local application of vinblastine to the sciatic nerve of the rat, J. Neurosci., 4:430
Fitzgerald, M., and Vrbova, G., 1985, Plasticity of acid phosphatase (FRAP) afferent terminal fields and of dorsal horn cell growth in the neonatal rat, J. Comp. Neurol., 240:414
Fitzgerald, M., Wall, P. D., Goedert, M., and Emson, P. C., 1985a, Nerve growth factor counteracts the neurophysiological and neurochemical effects of chronic sciatic nerve section, Brain. Res., 332:131
Fitzgerald, M., 1985b, The sprouting of saphenous nerve terminals in the spinal cord following early postnatal sciatic nerve section in the rat, J. Comp. Neurol., 240:407
Gobel, S., and Binck, J. M., 1977, Degenerative changes in primary trigeminal axons and in neurons in nucleus caudalis following tooth pulp extirpations in the cat, Brain Res., 132:347
Gobel, S., 1984, An electron microscopic analysis of the transsynaptic effects of peripheral nerve injury subsequent to tooth pulp extirpations on neurons in Lamina I and II of the medullary dorsal horn, J. Neuroscience, 4:2281
Goldberger, M. E., and Murray, M., 1974, Restitution of function and collateral sprouting in the rat spinal cord: the deafferentated animal. J. Comp. Neurol., 158:37
Grant, G., and Ygge, J., 1981, Somatotopical organization of the thoracic spinal nerve in the dorsal horn demonstrated with transganglionic degeneration, J. Comp. Neurol., 202:357
Grazidei, P. P. C., and Monti Grazidei, G. A., 1978, Continuous nerve cell renewal in the olfactory system, in: “Handbook of sensory Physiology, Vol. FX,” M. Jacobson, ed., Springer-Verlag, New York: 55
Gutman, E., Gutman, C., Medawar, P. B., and Young, J. Z., 1942, The rate of regeneration of nerve, J. Exp. Biol., 19:14
Hanzely, B., Knyihár-Csillik, E., and Csillik, B., 1983, Fluoride-resistant acid phosphatase (FRAP) activity of nociceptive nerve terminals in the dental pulp, Z. mikrosk. -anat. Forsch., 97:43
Horch, K. W., and Lisney, S. J. W., 1981, Changes in primary afferent depolarization of sensory neurons during peripheral nerve regeneration in the cat, J. Physiol. (Lond.), 313:287
Hökfelt, T., Kellerth, J. O., Nilsson, G., and Pernow, B., 1975, Experimental immunohistochemical studies on the localization and distribution of substance P in cat primary sensory neurons, Brain Res., 100:235
Hökfelt, T., Eide, R., Johansson, O., Luft, R., and Nilsson, G., 1976, Immunohistochemical evidence for separate populations of somatostatin-containing and substance P-containing primary afferent neurons in the rat, Neuroscience, 1:131
Jessell, T., Tsunoo, A., Kanazawa, I., and Otsuka, M., 1979, Substance P: depletion in the dorsal horn of rat spinal cord after section of the peripheral processes of primary sensory neurons, Brain Res., 168:247
Johnson, L. R., and Westrum, L. E., 1980, Brainstem degeneration patterns following tooth extractions: visualization of dental and periodontal afferents, Brain Res., 194:489
Johnson, L. R., Westrum, L. E., and Canfield, R. C., 1983, Ultrastructural study of transganglionic degeneration following dental lesions, Exp. Brain Res., 52:226
Katzman, R, Björklund, A., Owman, Ch., Stenevi, U., and West, K. A., 1971, Evidence for regenerative axon sprouting of central catecholamine neurons in rat mesencephalon following electrolytic lesions, Brain Res., 25:579
Kessler, J. A., and Black, I. B., 1981, Nerve growth factor stimulates development of substance P in the embryonic spinal cord, Brain Res., 208:135
Knyihár, E., and Csillik, B., 1976a, Representation of cutaneous afferents by fluoride-resistant acid phosphatase (FRAP)-active terminals in the rat substantia gelatinosa Rolandi, Acta neurol. scand., 53:217
Knyihár, E., and Csillik, B., 1976b, Effect of peripheral axotomy on the fine structure and histochenistry of the Rolando substance: degenerative atrophyj of central processes of pseudounipolar cells, Exp. Brain Res., 26:73
Knyihár, E., and Csillik, B., 1976c, Axonal labyrinths in the rat spinal cord. A consequence of degenerative atrophy, Acta Biol. Acad. Sci. Hung., 27:299
Knyihár, E., and Csillik, B., 1977, Regional distribution of acid phosphatase-positive axonal systems in the rat spinal cord and medulla, representing central terminals of cutaneous and visceral nociceptive neurons, J. Neural Transmiss., 40:227
Knyihár-Csillik, E., Bezzegh, A., Böti, Zs., and Csillik, B., 1986, Thiamine monophosphatase: A genuine marker for tansganglionic regulation of primary sensory neurons, J. Histochem. Cytochem., 34:363
Knyihár-Csillik, E., and Csillik, B., 1981, FRAP: Histochemistry of the primary nociceptive neuron, Progr. Histochem. Cytochem., 14:1
Knyihár-Csillik, E., Rakic, P., and Csillik, B., 1985, Fine structure of growth cones in the upper dorsal horn of the adult spinal cord in the course of reactive synaptoneogenesis, Cell Tiss. Res., 239:633
Knyihár-Csillik, E., Rakic, P., and Csillik, B., 1986, Reactive synaptoneogenesis in the upper dorsal horn of the adult primate: regenerative or collateral sprouting?, in: “Development and Plasticity of the mammalian spinal cord,” M. Goldberger, A. Gorio, and M. Murray, eds., Fidia Res. Series, Vol. III, Liviana Press, Padova
Knyihár-Csillik, E., Rakic, P., and Csillik, B., 1987, Transganglionic degenerative atrophy in the substantia gelatinosa of the spinal cord after peripheral nerve transection in rhesus monkeys, Cell Tiss. Res., 247:599
Knyihár-Csillik, E., Rakic, P., and Csillik, B., 1987, Transganglionic degenerative atrophy in the substantia gelatinosa of the spinal cord after peripheral nerve transection in rhesus monkeys, Cell Tiss. Res., 247:599
Kovacs, A., and Ferencsik, M., 1986, Mapping of spinal projection of primary nociceptive neurones in the rat, Acta Morph. Hung., 34:187
Kreutzberg, G. W., 1985, The motoneuron and its microenvironment responding to axotomy, in: “Neural transplantation and regeneration,” G. D. Das and R. B. Wallace, eds., Springer-Verlag, New York: 271
Léránth, Cs., Csillik, B., and Knyihár-Csillik, E., 1984, Depletion of substance P and somatostatin in the upper dorsal horn after blockade of axoplasmic transport, Histochem., 81:391
Ljungdahl, A., Hökfelt, T., and Nilsson, G., 1978, Distribution of substance P-like immunoreactivity in the central nervous system of the rat, Neuroscience, 3:861
Lynch, G., Matthews, D. A., Mosko, S., Parks, T., and Cotman, C. W., 1972, Induced acetylcholinesterase-rich layer in rat dentate gyrus following entorhinal lesions, Brain Res., 42:311
Lynch, G., Stanfield, B., and Cotman, C. W., 1973, Development differences in postlesion axonal growth in the hippocampus, Brain Res., 59:155
Majumdar, S., Mills, E., and Smith, P. G., 1983, Degenerative and regenerative changes in central projections of glossopharyngeal and vagal sensory neurons after peripheral axotomy in cats: a structural basis for central reorganization of arterial chemoreflex pathways, Neuroscience, 10:841
Mayer, N., Lembeck, F., Goedert, M., and Otten, U., 1982, Effects of antibodies against nerve growth factor on the postnatal development of substance P — containing sensory neurons, Neurosci. Lett., 29:47
McGregor, G. P., Gibson, S. J., Sabate, I. M., Blank, M. A., and Christofìdes, N. D., 1984, Effect of peripheral nerve section and nerve crush on spinal cord neuropeptides in the rat; increased VIP and PHI in the dorsal horn, Neuroscience, 13:207
Mihaly, A., Pór, I., Bencze, Gy., and Csillik, B., 1980, Effects of perineurally applied cytostatic, cytotoxic and chelating agents upon peripheral and central processes of primary nociceptive neurons, Z. mikrosk.-anat. Forsch., 94:531
Nadelhaft, I., 1984, The sessile drop method immunohistochemical processing of unmounted sections of nervous tissue, J. Histochem. Cytochem., 32:1344
Nagy, J. I., and Hunt, S. P., 1982, Fluoride-resistant acid phosphatase-containing neurones in dorsal root ganlgia are separate from those containing substance P or somatostatin, Neurosci., 378:188
Ogawa, K., Sakai, M., and Inomata, K., 1982, Recent findings on ultracytochemistry of thiamin phosphatases, Ann. N. Y. Acad. Sci., 378:188
Pór, I., 1985, Alterations of dorsal root potential in the course of tranganglionic degenerative atrophy, Acta Physiol. Hung., 65:255
Prestige, M. C., 1967, The control of cell number in the lumbar spinal ganglia during the development of Xenopus laevistadpoles, J. Embryol. Morph., 17:453
Risling, M., Aldskogius, H., Hildebrand, C., and Remahl, S., 1983, Effects of sciatic nerve resection on L7 spinal root and dorsal root ganglia in adult cats, Exp. Neurol., 82:568
Seybold, V., and Eide, R., 1980, Immunohistochemical studies of peptidergic neurons in the dorsal horn of the spinal cord, J. Histochem. Cytochem., 28:367
Shehab, S. A. S., and Atkinson, M. E., 1986, Vasoactive intestinal polypeptide (VIP) increases in the spinal cord after peripheral axotomy of the sciatic nerve originate from primary afferent neurons, Brain Res., 372:3
Szuecs, A., Csillik, B., and Knyihár-Csillik, E., 1983, Functional impairment of the primary nociceptive analyzer in the course of transganglionic degenerative atrophy, Acta Biol. Acad. Sci. Hung., 34:267
Szönyi, G., Knyihár, E., and Csillik, B., 1979, Extra-lysosomal fluoride-resistant acid phosphatase active neuronal system subserving nociciption in the rat cornea, Z. mikrosk.-anat. Forsch., 93:974
Tajti, J., Fischer, J., Knyihár-Csillik, E., and Csillik, B., 1988, Tranganglionic regulation and fine structural localization of lectin-reactive carbohydrate epitopes in primary sensory neurons of the rat, Histochemistry, 88:213
Tajti, J., Fischer, J., Knyihár-Csillik, E., and Csillik, B., 1988, Tranganglionic regulation and fine structural localization of lectin-reactive carbohydrate epitopes in primary sensory neurons of the rat, Histochemistry, 88:213
Takahashi, T., and Otsuka, M., 1975, Regional distribution of substance P in the spinal cord and nerve roots of the cat and the effect of dorsal root section, Brain Res., 87:1
Tessler, A., Hirnes, B. T., Krieger, N. R., Murray, M., and Goldberger, M. E., 1985, Sciatic nerve transection produces death of dorsal root ganglion cells and reversible loss of substance P in spinal cord, Brain Res., 332:209
Unsicker, K., Skaper, S. D., and Varon, S., 1985, Developmental changes in the responses of rat chromaffine cells to neurotrophic and neurite-promoting factors, Develop. Biol., 111:425
Wall, P. D., Fitzgerald, M., and Gibson, S. J., 1981a, The response of rat spinal cord cells to unmyelinated afferents after peripheral nerve section and after changes in substance P levels, Neuroscience, 6:2205
Wall, P. D., 1981b, The nature and origins of plasticity in adult spinal cord, in: “Spinal cord sensation,” A. G. Brown and M. Réthelyi, eds., Scottish Academic Press, Edinburgh: 297
Wall, P. D., Mills, R., Fitzgerald, M., and Gibson, S. J., 1982a, Chronic blockade of sciatic nerve transmission by tetrodotoxin does not produce central changes in the dorsal horn of the spinal cord of the rat, Neurosci. Lett., 30:315
Wall, P. D., 1982b, The effect of peripheral nerve lesions and of neonatal capsaicin in the rat on primary afferent depolarization, J. Physiol. (Lond.), 329:21
Wall, P. D., and Devor, M., 1981, The effect of peripheral nerve injury on dorsal root potentials and on transmission of afferent signals into the spinal cord, Brain Res., 209:95
Westrum, L. E., and Canfield, R. C., 1977, Light and electron microscopy of degeneration in the brain stem spinal trigeminal nucleus following tooth pulp removal in adult cats, in: “Pain in trigeminal region,” D. J. Anderson and B. Matthews, eds., Elsevier, Amsterdam-New York: 171
Westrum, L. E., Johnson, L. R., and Canfield, R. C, 1984, Ultrastructure of transganglionic degeneration in brain stem trigeminal nuclei during normal primary tooth exfoliation and permanent tooth eruption in the cat, J. Comp. Neurol., 230:198
Woolf, C. J., and Wall, P. D., 1982, Chronic peripheral nerve section diminished the primary afferent A-fibre mediated inhibition of rat dorsal horn neurones, Brain Res., 242:77
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Knyihár-Csillik, E., Csillik, B. (1990). Structural, Functional and Cytochemical Plasticity of Primary Afferent Terminals in the Upper Dorsal Horn. In: Zenker, W., Neuhuber, W.L. (eds) The Primary Afferent Neuron. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-0579-8_18
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