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Pharmacological Application of Prostaglandins, Their Analogues, and Their Inhibitors in Obstetrics

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Book cover Uterine Function

Abstract

The central role of eicosanoids, particularly prostaglandin (PG) E2 and PGF2α, in human parturition has been well documented in other chapters of this book. The following conclusions can be drawn: (1) prostaglandins reliably cause cervical ripening and uterine contractions, which result in pregnancy termination at any gestational age; the uterine sensitivity increases as term gestation is approached; (2) increasing concentration of arachidonic acid, precursor of prostaglandins, occurs in amniotic fluid of women in labor; (3) intraamniotic injection of arachidonic acid stimulates labor; and (4) inhibitors of prostaglandin synthesis can diminish or prevent uterine contractions.1-2

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  1. Department of Obstetrics and Gynecology, University of Michigan Medical School, Ann Arbor, Michigan, 48109, USA

    Robert H. Hayashi

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  1. School of Medicine, University of California, Los Angeles, Los Angeles, California, USA

    Mary E. Carsten  & Jordan D. Miller  & 

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© 1990 Plenum Press, New York

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Hayashi, R.H. (1990). Pharmacological Application of Prostaglandins, Their Analogues, and Their Inhibitors in Obstetrics. In: Carsten, M.E., Miller, J.D. (eds) Uterine Function. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-0575-0_15

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  • DOI: https://doi.org/10.1007/978-1-4613-0575-0_15

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