Skip to main content
SpringerLink
Log in

Oxytocin Receptors in the Uterus

  • Chapter
Uterine Function

Abstract

Oxytocin is a nonapeptide that is synthesized by magnocellular neurons of the hypothalamus and, as shown within the past 10 years, by ovarian luteal cells of certain species.1–3 The peptide is similar in structure to arginine vasopressin, or antidiuretic hormone (Fig. 1), accounting for each having overlapping activities on the other’s target cells. Thus, vasopressin will cause uterine contractions in experimental animals, but considerably higher doses are required to obtain the same response as with oxytocin. Labor at term can be induced either by giving exogenous oxytocin or by stimulating endogenous oxytocin release.4 Despite these findings, many investigators have felt that oxytocin is not a physiological initiator of labor because fluctuations in its concentration in the blood immediately before labor do not correspond to changes in uterine activity. It now seems clear, from data collected in several species, that oxytocin’s activity during pregnancy and labor depends more on the sensitivity of myometrial cells than on the concentration of the hormone in the circulation.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
eBook
USD 16.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Fields, M. J., Fields, P. A., Castro-Hernandez, A., and Larkin, L. H., 1980, Evidence for relaxin in corpora lutea of late pregnant cows, Endocrinology 107:869–876.

    Article  PubMed  CAS  Google Scholar 

  2. Wathes, D. C., and Swann, R. W., 1982, Is oxytocin an ovarian hormone? Nature 297:225–227.

    Article  PubMed  CAS  Google Scholar 

  3. Wathes, D. C., 1984, Possible actions of gonadal oxytocin and vasopressin, J. Reprod. Fertil 71:315–345.

    Article  PubMed  CAS  Google Scholar 

  4. Boer, K., Lincoln, D. W., and Swaab, D. F., 1975, Effects of electrical stimulation of the neurohypophysis on labour in the rat, J. Endocrinol 65:163–176.

    Article  PubMed  CAS  Google Scholar 

  5. Soloff, M. S., Alexandrova, M., and Femström, M. J., 1979, Oxytocin receptors: Triggers for parturition and lactation? Science 204:1313–1315.

    Article  PubMed  CAS  Google Scholar 

  6. Alexandrova, M., and Soloff, M. S., 1980, Oxytocin receptors and parturition. I. Control of oxytocin receptor concentration in the rat myometrium at term, Endocrinology 106:730–735.

    Article  PubMed  CAS  Google Scholar 

  7. Fuchs, A.-R., Periyasamy, S., Alexandrova, M., and Soloff, M. S., 1983, Correlation between oxytocin receptor concentration and responsiveness to oxytocin in pregnant rat myometrium. Effect of ovarian steroids, Endocrinology 113:742–749.

    Article  PubMed  CAS  Google Scholar 

  8. Alexandrova, M., and Soloff, M. S., 1980, Oxytocin receptors and parturition in the guinea pig, Biol. Reprod 22:1106–1111.

    PubMed  CAS  Google Scholar 

  9. Sakamoto, H., Den, K., Yamamoto, K., Arai, T., Kawai, S., Oyama, Y., Yoshida, T., and Takagi, S., 1979, Study of oxytocin receptor in human myometrium using highly specific 3H-labeled oxytocin, Endocrinol. Jpn 26:515–522.

    PubMed  CAS  Google Scholar 

  10. Fuchs, A.-R., Fuchs, F., Husslein, P., Soloff, M. S., and Fernstrom, M. J., 1982, Oxytocin receptors and human parturition. A dual role for oxytocin in the initiation of labor, Science 215:1396–1398.

    Article  PubMed  CAS  Google Scholar 

  11. Riemer, R. K., Goldfien, A. C., Goldfien, A., and Roberts, J. M., 1986, Rabbit uterine oxytocin receptors and in vitrocontractile response: Abrupt changes at term and the role of eicosanoids, Endocrinology 119:669–709.

    Article  Google Scholar 

  12. Alexandrova, M., and Soloff, M. S., 1980, Oxytocin receptors and parturition. III. Increases in estrogen receptor and oxytocin receptor concentrations in the rat myometrium during PGF2α- induced abortion, Endocrinology 106:739–743.

    Article  PubMed  CAS  Google Scholar 

  13. Fuchs, A.-R., Fuchs, F., Husslein, P., and Soloff, M. S., 1984, Oxytocin receptors in the human uterus during pregnancy and parturition, Am. J. Obstet. Gynecol 150:734–741.

    PubMed  CAS  Google Scholar 

  14. Bercu, B. B., Hyashi, A., Poth, M. Alexandrova, M., Soloff, M. S., and Donahoe, P. K., 1980, LHRH induced delay of parturition, Endocrinology 107:504–508.

    Article  PubMed  CAS  Google Scholar 

  15. Fuchs, A.-R., Husslein, P., and Fuchs, F., 1981, Oxytocin and the initiation of human parturition. II. Stimulation of prostaglandin production in human decidua by oxytocin, Am. J. Obstet. Gynecol 141:694–697.

    PubMed  CAS  Google Scholar 

  16. Wilson, T., Liggins, G. C., and Whittaker, D. J., 1988, Oxytocin stimulates the release of arachidonic acid and prostaglandin F2ot from human decidual cells, Prostaglandins 35:771–780.

    Article  PubMed  CAS  Google Scholar 

  17. Soloff, M. S., 1979, Regulation of oxytocin action at the receptor level, Life Sci.25:1453–1460.

    Article  PubMed  CAS  Google Scholar 

  18. Soloff, M. S., 1985, Oxytocin receptors and mechanisms of oxytocin action, in: Oxytocin: Clinical and Laboratory Studies( J. A. Amico and A. G. Robinson, eds.), Elsevier Scientific, Amsterdam, pp. 259–276.

    Google Scholar 

  19. Morgat, J. L., Hung, L. T., Cardinaud, R., Fromageot, P., Bockaert, J., Imbert, M., and Morel, F., 1970, Peptidic hormone interactions at the molecular level—Preparation of highly labelled 3H oxytocin, J. Labelled Compd 6:276–284.

    Article  CAS  Google Scholar 

  20. Flouret, G., Terada, S., Yang, F., Nakagawa, S. H., Nakahara, T., and Hechter, O., 1977, Iodinated neurohypophyseal hormones as potential ligands for receptor binding and intermediates in synthesis of tritiated hormones, Biochemistry 16:2119–2124.

    Article  PubMed  CAS  Google Scholar 

  21. Elands, J., Barberis, C., Jard, S., Tribollet, E., Dreifuss, J.-J., Bankowski, K., Manning, M., and Sawyer, W. H., 1987, 125l-Labelled d(CH2)5[Tyr(Me)2,Thr4,Tyr9]OVT: A selective oxytocin receptor ligand, Eur. J. Pharmacol 147:197–207

    Article  Google Scholar 

  22. Soloff, M. S., Schroeder, B. T., Chakraborty, J., and Pearlmutter, A. F., 1977, Characterization of oxytocin receptors in the uterus and mammary gland, Fed. Proc 36:1861–1866.

    PubMed  CAS  Google Scholar 

  23. Matlib, M. A., Crankshaw, J., Garfield, R. E., Crankshaw, D. J., Kwan, C.-Y., Branda, L. A., and Daniel, E. E., 1979, Characterization of membrane fractions and isolation of purified plasma membranes from rat myometrium, J. Biol. Chem 254:1834–1840.

    PubMed  CAS  Google Scholar 

  24. Scatchard, G., 1949, The attraction of proteins for small molecules and ions, Ann. N.Y. Acad. Sci 51:660–672.

    Article  CAS  Google Scholar 

  25. Roberts, J. S., McCracken, J. A., Gavagan, J. E., and Soloff, M. S., 1976, Oxytocin-stimulated release of prostaglandin F2α from ovine endometrium in vitro:Correlation with estrous cycle and oxytocin-receptor binding, Endocrinology 99:1107–1114.

    Article  PubMed  CAS  Google Scholar 

  26. Soloff, M. S., Fernström, M. A., Periyasamy, S., Soloff, S., Baldwin, S., and Wieder, M., 1983, Regulation of oxytocin receptor concentration in rat uterine explants by estrogen and progesterone, Can. J. Biochem. Cell Biol 61:625–630.

    Article  PubMed  CAS  Google Scholar 

  27. van Dyke, H. B., and Hastings, A. B., 1928, The response of smooth muscle in different ionic environments, Am. J. Physiol 83:563–577.

    Google Scholar 

  28. Clegg, P. C., Hopkinson, P., and Pickles, V. R., 1963, Some effects of calcium and magnesium ions on guinea-pig uterine muscle, J. Physiol. (Lond.) 167:1–17.

    CAS  Google Scholar 

  29. Bentley, P. J., 1965, The potentiating action of magnesium and manganese on the oxytocic effect of some oxytocin analogues, J. Endocrinol 32:215–222.

    Article  PubMed  CAS  Google Scholar 

  30. Krejci, I., and Polacek, I., 1968, Effect of magnesium on the action of oxytocin and a group of analogues on the uterus in vitro, Eur. J. Pharmacol.2:393–398.

    Article  PubMed  CAS  Google Scholar 

  31. Walter, R., Dubois, B. M., and Schwartz, I. L., 1968, Biological significance of the amino acid residue in position 3 of neurohypophyseal hormones and the effect of magnesium on their uterotonic action, Endocrinology 83:979–983.

    Article  PubMed  CAS  Google Scholar 

  32. Schild, H. O., 1969, The effect of metals on the S-S polypeptide receptor in depolarized rat uterus, Br. J. Pharmacol 36:329–349.

    PubMed  CAS  Google Scholar 

  33. Pearlmutter, A. F., and Soloff, M. S., 1979, Characterization of the metal ion requirement for oxytocin-receptor interaction in rat mammary gland membranes, J. Biol. Chem, 254:3899–3906.

    PubMed  CAS  Google Scholar 

  34. Soloff, M. S., and Swartz, T. L., 1974, Characterization of a proposed oxytocin receptor in the uterus of the rat and sow, J. Biol. Chem 249:1376–1381.

    PubMed  CAS  Google Scholar 

  35. Chan, W. Y., and Kelly, N., 1967, A pharmacological analysis on the significance of the chemical functional groups on oxytocin to its oxytocic activity and on the effect of magnesium on the in vitroand in vivooxytocin activity of neurohypophysial hormones, J. Pharmacol. Exp. Ther 156:150–158.

    PubMed  CAS  Google Scholar 

  36. Rudinger, J., 1968, Synthetic analogues of oxytocin: An approach to problems of hormone action, Proc. R. Soc. Lond.[Biol.] 170:17–26.

    Article  CAS  Google Scholar 

  37. Rudinger, J., Pliska, V., and Krejci, I., 1972, Oxytocin analogs in the analysis of some phases of hormone action, Recent Prog. Horm. Res 28:131–172.

    PubMed  CAS  Google Scholar 

  38. Manning, M., Coy, E., and Sawyer, W. H., 1970, Solid phase synthesis of 4-threonine oxytocin. A more potent and specific oxytocic agent than oxytocin, Biochemistry 9:3925–3930.

    Article  PubMed  CAS  Google Scholar 

  39. Sawyer, W. H., and Manning, M., 1971, 4-Threonine analogues of neurohypophysial hormones with selectively enhanced oxytocin-like activities, J. Endocrinol 49:151–165

    Article  PubMed  CAS  Google Scholar 

  40. Soloff, M. S., and Grzonka, Z., 1986, Effect of manganese on relative affinities of receptor for oxytocin analogues. Binding studies with rat myometrial and mammary gland membranes, J. Biol. Chem 254:3899–3906.

    Google Scholar 

  41. Joelsson, I., Ingelman-Sundberg, A., and Sandberg, F., 1966, The in vivoeffect of oxytocin and vasopressin on the nonpregnant human uterus, J. Obstet. Gynaecol. Br. Commonw 73:832–836.

    Article  PubMed  CAS  Google Scholar 

  42. Coutinho, E. M., and Lopes, A. C. V., 1968, Response of the nonpregnant uterus to vasopressin as an index of ovarian function, Am. J. Obstet. Gynecol 102:479–489.

    Google Scholar 

  43. Bengtsson, L. P., 1970, Effect of progesterone upon the in vivoresponse of the human myo-metrium to oxytocin and vasopressin, Acta Obstet. Gynecol. Scand 49(Suppl. 6): 19–25.

    Article  Google Scholar 

  44. Embrey, M. P., and Moir, J. C., 1967, A comparison of the oxytocic effects of synthetic vas-opressin and oxytocin, J. Obstet. Gynaecol. Br. Commonw 74:648–652.

    Article  PubMed  CAS  Google Scholar 

  45. Cobo, E., Cifuentes, R., and de Villamizar, M., 1978, Inhibition of menstrual uterine motility during water diuresis.J.Obstet. Gynecol 132:313–320.

    CAS  Google Scholar 

  46. Caldeyro-Barcia, R., and Sereno, J., 1961, The response of the human uterus to oxytocin throughout pregnancy, in: Oxytocin( R. Caldeyro-Barcia and H. Heller, eds.), Pergamon Press, Oxford, pp. 177–202.

    Google Scholar 

  47. Fuchs, A.-R., Fuchs, F., and Soloff, M. S., 1985, Oxytocin receptors in nonpregnant human uterus, J. Clin. Endorcinol. Metab 60:37–41.

    Article  CAS  Google Scholar 

  48. Guillon, G., Balestre, M. N., Roberts, J. M., and Bottari, S. P., 1987, Oxytocin and vasopressin: Distinct receptors in myometrium, J. Clin. Endocrinol. Metab 64:1129–1135.

    Article  PubMed  CAS  Google Scholar 

  49. Soloff, M. S., and Fernstrom, M. A., 1987, Solubilization and properties of oxytocin receptors in rat mammary gland membranes, Endocrinology 120:2474–2482.

    Article  PubMed  CAS  Google Scholar 

  50. Edelman, G. M., 1976, Surface modulation in cell recognition and cell growth, Science 198:218–226.

    Article  Google Scholar 

  51. Mescher, M. R., Jose, M. J. L., and Balk, S. P., 1981, Actin-containing matrix associated with the plasma membrane of murine tumour and lymphoid cells, Nature 289:139–144.

    Article  PubMed  CAS  Google Scholar 

  52. Small, J. V., 1974, Contractile units in vertebrate smooth muscle cells, Nature 249:324–327.

    Article  PubMed  CAS  Google Scholar 

  53. Soloff, M. S., Beauregard, G., and Potier, M., 1988, Determination of the functional size of oxytocin receptors in plasma membranes from mammary gland and uterine myometrium of the rat by radiation inactivation, Endocrinology 122:1769–1772.

    Article  PubMed  CAS  Google Scholar 

  54. Glass, J. D., and du Vigneaud, V., 1972, Synthesis and certain pharmacological properties of ysine-vasopressinoic acid methylamide and lysine-vasopressinoic acid diethylamide, J. Med. Chem 15:486–488.

    Article  PubMed  CAS  Google Scholar 

  55. Manning, M., Olma, A., Klis, W., Kolodziejczyk, A., Nawrocka, E., Misicka, A., Seto, J., and Sawyer, W. H., 1984, Carboxy terminus of vasopressin required for activity but not binding, Nature 308:652–653.

    Article  PubMed  CAS  Google Scholar 

  56. Berde, B., and Boissonnas, R. A., 1968, Basic pharmacological properties of synthetic analogues and homologues of the neurohypophysial hormones, in: Handbook of Experimental Pharmacology, Volume XXIII.Neurohypophysial Hormones and Similar Polypeptides( B. Berde, ed.), Springer- Verlag, New York, pp. 802–870.

    Google Scholar 

  57. Marshall, J. M., 1974, Effects of neurohypophysial hormones on the myometrium, in: The Pituitary Gland and its Neuroendocrine Control, Part 1, Handbook of Physiology, Section 7: Endocrinology, Volume IV ( R. O. Greep, E. B. Astwood, E. Knobil, W. H. Sawyer, and S. R. Geiger, eds.), American Physiological Society, Washington, DC, pp. 469–492.

    Google Scholar 

  58. Forman, A., Gandrup, P., Andersson, K. E., and Ulmsten, U., 1982, Effects of nifedipine on oxytocin- and prostaglandin F2α-induced activity in the postpartum uterus, Am. J. Obstet. Gynecol 144:665–670.

    PubMed  CAS  Google Scholar 

  59. Sakai, K., Yamaguchi, T., Morita, S., and Uchida, M., 1983, Agonist-induced contraction of rat myometrium in Ca-free solution containing Mn, Gen. Pharmacol 14:391–400.

    PubMed  CAS  Google Scholar 

  60. Cantor, E. H., Kenessey, A., Semenuk, G., and Spector, S., 1984, Interaction of calcium channel blockers with non-neuronal benzodiazepine binding sites, Proc. Natl. Acad. Sci. U.S.A 81:1549–1552.

    Article  PubMed  CAS  Google Scholar 

  61. Schatzmann, H. J., and Vincenzi, F. F., 1969, Calcium movements across the membrane of human red cells, J. Physiol. (Lond.) 201:369–395.

    CAS  Google Scholar 

  62. Pershadsingh, H. A., and McDonald, J. M., 1980, A high affinity calcium-stimulated magnesium- dependent adenosine triphosphatase in rat adipocyte plasma membranes, J. Biol. Chem 255:4087–4093.

    PubMed  CAS  Google Scholar 

  63. Wuytack, F., Raeymaekers, L., Verbist, J., De Smedt, H., and Casteels, R., 1984, Evidence for the presence in smooth muscle of two types of Ca2 + -transport ATPase, Biochem. J 224:445–451.

    PubMed  CAS  Google Scholar 

  64. Caroni, P., and Carafoli, E., 1981, The Ca2+-pumping ATPase of heart sarcolemma. Characterization, calmodulin dependence, and partial purification, J. Biol. Chem 256:3263–3270.

    PubMed  CAS  Google Scholar 

  65. Caroni, P., Zurini, M., Clark, A., and Carafoli, E., 1983, Further characterization and reconstitution of the purified Ca2 +-pumping ATPase of heart sarcolemma, J. Biol. Chem 258:7305–7310.

    PubMed  CAS  Google Scholar 

  66. Åkerman, K. E. O., and Wikström, M. K. F., 1979, (Ca2+ + Mg2 +)-stimulated ATPase activity of rabbit myometrium plasma membrane is blocked by oxytocin, FEBS Lett.97:283–287

    Article  PubMed  Google Scholar 

  67. Soloff, M. S., and Sweet, P., 1982, Oxytocin inhibition of (Ca2+ + Mg2 +)ATPase activity in rat myometrial plasma membranes, J. Biol. Chem 257:10687–10693.

    PubMed  CAS  Google Scholar 

  68. Huszar, G., 1986, Cellular regulation of myometrial contractility and essentials of tocolytic thera¬py, in: The Physiology and Biochemistry of the Uterus in Pregnancy and Labor( G. Huszar, ed.), CRC Press, Boca Raton, FL, pp. 107–126.

    Google Scholar 

  69. Popescu, L. M., Nutu, O., and Panoiu, C., 1985, Oxytocin contracts the human uterus at term by inhibiting the myometrial Ca2 + -extrusion pump, Bio sci. Rep 5:21–28

    Article  CAS  Google Scholar 

  70. Pershadsingh, H. A., and McDonald, J. M., 1979, Direct addition of insulin inhibits a high affinity Ca2 +-ATPase in isolated adipocyte plasma membranes, Nature 281:495–497.

    Article  PubMed  CAS  Google Scholar 

  71. Yamaguchi, M., 1979, Effect of calcitonin on Ca-ATPase activity of plasma membrane in liver of rats, Endocrinol. Jpn 26:605–609.

    PubMed  CAS  Google Scholar 

  72. Lin, S.-H., Wallace, M. A., and Fain, J. N., 1983, Regulation of Ca2 +-Mg2 +-ATPase activity in hepatocyte plasma membranes by vasopressin and phenylephrine, Endocrinology 113:2268–2275.

    Article  PubMed  CAS  Google Scholar 

  73. Marc, S., Lieber, D., and Harbon, S., 1986, Carbachol and oxytocin stimulate the generation of inositol phosphates in the guinea pig myometrium, FEBS Lett.201:9–14.

    Article  PubMed  CAS  Google Scholar 

  74. Schrey, M. P., Read, A. M., and Steer, P. J., 1986, Oxytocin and vasopressin stimulate inositol phosphate production in human gestational myometrium and decidual cells, Biosci. Rep 6:613–619.

    Article  PubMed  CAS  Google Scholar 

  75. Carsten, M. E., and Miller, J. D., 1985, Ca2+ release by inositol trisphosphate from Ca2 + - transporting microsomes derived from uterine sarcoplasmic reticulum, Biochem. Biophys. Res. Commun 130:1027–1031.

    Article  PubMed  CAS  Google Scholar 

  76. Streb, H., Bayerdorffer, E., Hasse, W., Irvine, R. F., and Schulz, I., 1984, Effect of inositol- 1,4,5-trisphosphate on isolated subcellular fractions of rat pancreas, J. Membr. Biol 81:241–253.

    Article  PubMed  CAS  Google Scholar 

  77. Spät, A., Fabiato, A., and Rubin, R. P., 1986, Binding of inositol trisphosphate by a liver microsomal fraction, Biochem. J 233:929–932.

    PubMed  Google Scholar 

  78. Zhao, X., and Gorewit, R. C., 1987, Inositol-phosphate response to oxytocin-stimulation in dispersed bovine mammary cells, Neuropeptides 10:227–233.

    Article  PubMed  CAS  Google Scholar 

  79. Soloff, M. S., Fernstrom, M. A., and Fernstrom, M. J., 1989, Vasopressin and oxytocin receptors on plasma membranes from rat mammary gland. Demonstration of vasopressin receptors by stimulation of inositol phosphate formation, and oxytocin receptors by binding of a specific 1251- labeled oxytocin antagonist, d(CH2)51[Tyr(Me)2,Thr4,Tyr-NH29]OVT, Biochem. Cell Biol 67:152–162.

    Article  PubMed  CAS  Google Scholar 

  80. Tolbert, M. E. M., White, A. C., Aspry, K., Cutts, J., and Fain, J. N., 1980, Stimulation by vasopressin and α-catecholamines of phosphatidylinositol formation in isolated rat liver parenchymal cells, J. Biol. Chem 255:1938–1944.

    PubMed  CAS  Google Scholar 

  81. Kirk, C. J., and Michell, R. H., 1981, Phosphatidylinositol metabolism in rat hepatocytes stimulated by vasopressin, Biochem. J 194:155–165.

    PubMed  CAS  Google Scholar 

  82. Bhalla, T., Enyedi, P., Spat, A., and Antoni, F. A., 1985, Pressor-type vasopressin receptors in the adrenal cortex: Properties of binding, effects on phosphoinositide metabolism and aldosterone secretion, Endocrinology 117:421–423.

    Article  Google Scholar 

  83. Woodcock, E. A., McLeod, J. K., and Johnston, C. I., 1986, Vasopressin stimulates phos-phatidylinositol turnover and aldosterone synthesis in rat adrenal glomerulosa cells: Comparison with angiotensin II, Endocrinology 118:2432–2436.

    Article  PubMed  CAS  Google Scholar 

  84. Koreh, K., and Monaco, M. E., 1986, The relationship of hormone-sensitive and hormone-insensitive phosphatidylinositol to phosphatidylinositol 4,5-bisphosphate in the WRK-1 cell, J. Biol. Chem 261:88–91.

    PubMed  CAS  Google Scholar 

  85. Kirk, C. J., Guillon, G., Balestre, M.-N., and Jard, S., 1986, Stimulation by vasopressin and other agonists, of inositol-lipid breakdown and inositol phosphate accumulation in WRK1 cells, Biochem. J 240:197–204.

    PubMed  CAS  Google Scholar 

  86. Nabika, T., Velletri, P. A., Lovenberg, W., and Beaven, M. A., 1985, Increase in cytosolic calcium and phosphoinositide metabolism induced by angiotensin II and [Arg]vasopressin in vascular smooth muscle cells, J. Biol. Chem 260:4661–4670.

    PubMed  CAS  Google Scholar 

  87. Aiyar, N., Nambi, P., Stassen, F. L., and Crooke, S. T., 1986, Vascular vasopressin receptors mediate phosphatidylinositol turnover and calcium efflux in an established smooth muscle cell line, Life Sci.39:37–45.

    Article  PubMed  CAS  Google Scholar 

  88. Fox, A. W., Friedman, P. A., and Abel, P. W., 1987, Vasopressin receptor mediated contraction and [3H]inositol metabolisms in rat tail artery, Eur. J. Pharmacol 135:1–10.

    Article  PubMed  CAS  Google Scholar 

  89. Casey, P. J., and Gilman, A. G., 1988, G. protein involvement in receptor-effector coupling, J. Biol. Chem 263:2577–2580.

    PubMed  CAS  Google Scholar 

  90. Fischer, J. B., and Schonbrunn, A., 1988, The bombesin receptor is coupled to a guanine nucleotide-binding protein which is insensitive to pertussis and cholera toxins, J. Biol. Chem 263:2808–2816.

    PubMed  CAS  Google Scholar 

  91. Goodman, R. R., Cooper, M. J., Gavish, M., and Snyder, S. H., 1982, Guanine nucleotide and cation regulation of the binding of [3H]cyclohexyladenosine and [3H]diethylphenylxanthine to adenosine A1 receptors in brain membranes, Mol. Pharmacol 21:329–335.

    PubMed  CAS  Google Scholar 

  92. Koch, B. D., and Schonbrunn, A., 1984, The somatostatin receptor is directly coupled to adenylate cyclase in GH4Q pituitary cell membranes, Endocrinology 114:1784–1790.

    Article  PubMed  CAS  Google Scholar 

  93. Hinkle, P. M., and Kinsella, P. A., 1984, Regulation of thyrotropin-releasing hormone binding by monovalent cations and guanyl nucleotides, J. Biol. Chem 259:3445–3449.

    PubMed  CAS  Google Scholar 

  94. U’Prichard, D. C., and Snyder, S. H., 1978, Guanyl nucleotide influences of 3H-ligand binding to α-noradrenergic receptors in calf brain membranes, J. Biol. Chem 253:3444–3449.

    Google Scholar 

  95. Soloff, M. S., 1975, Uterine receptors for oxytocin: Effects of estrogens, Biochem. Biophys. Res. Commun 65:205–212.

    Article  PubMed  CAS  Google Scholar 

  96. Nissenson, R., Flouret, G., and Hechter, O., 1978, Opposing effects of estradiol and progesterone on oxytocin receptors in rabbit uterus, Proc. Natl. Acad. Sci. U.S.A 75:2044–2048.

    Article  PubMed  CAS  Google Scholar 

  97. Fuchs, A.-R., Fuchs, F., and Soloff, M. S., 1985, Oxytocin receptors in nonpregnant human uterus, J. Clin. Endocrinol. Metab 60:37–41.

    Article  PubMed  CAS  Google Scholar 

  98. Sharma, S. C., and Fitzpatrick, R. J., 1974, Effect of oestradiol-17β and oxytocin on prostaglandin F alpha release in the anoestrous ewe, Prostaglandins 6:97–105.

    Article  PubMed  CAS  Google Scholar 

  99. Mitchell, M. D., Flint, A. P.F., and Turnbull, A. C., 1975, Stimulation by oxytocin of prostaglandin F levels in uterine venous effluent in pregnant and puerperal sheep, Prostaglandins 9:47–56.

    Article  PubMed  CAS  Google Scholar 

  100. Newcomb, R., Booth, W. D., and Rowson, L. E. A., 1977, The effect of oxytocin treatment on the levels of prostaglandin F in the blood of heifers, J. Reprod. Fertil 49:17–24.

    Article  PubMed  CAS  Google Scholar 

  101. Milvae, R. A., and Hansel, W., 1980, Concurrent uterine venous and ovarian arterial prostaglandin F concentrations in heifers treated with oxytocin, J. Reprod. Fertil 60:7–15.

    Article  Google Scholar 

  102. Oyedipe, E. O., Gustafsson, B., and Kindahl, H., 1984, Blood levels of progesterone and 15- keto-13,14-dihydroprostaglandin F2α during the estrous cycle of oxytocin treated cows, Theriogenology 22:329–339.

    Article  PubMed  CAS  Google Scholar 

  103. Chan, W. Y., 1977, Relationship between the uterotonic action of oxytocin and prostaglandins: Oxytocin action and release of PG-activity in isolated nonpregnant and pregnant rat uteri, Biol. Reprod 17:541–548.

    Article  PubMed  CAS  Google Scholar 

  104. Forsling, M. L., Åkerlund, M., and Strömberg, P., 1981, Variations in plasma concentrations of vasopressin during the menstrual cycle, J. Endocrinology 89:263–266.

    Article  CAS  Google Scholar 

  105. Strömberg, P., Åkerlund, M., Forsling, M. L., and Kindahl, H., 1983, Involvement of prostaglandins in vasopressin stimulation of the human uterus, Br. J. Obstet. Gynecol 90:332–337.

    Article  Google Scholar 

  106. Hixon, J. E., and Flint, A. P. F., 1988, Effects of a luteolytic dose of oestradiol benzoate on uterine oxytocin receptor concentrations, phosphoinositide turnover and prostaglandin F2α secretion in sheep, J. Reprod. Fertil 79:457–467.

    Google Scholar 

  107. Flint, A. P. F., Leat, W. M. F., Sheldrick, E. L., and Stewart, H. J., 1986, Stimulation of phosphoinositide hydrolysis by oxytocin and the mechanism by which oxytocin controls prostaglandin synthesis in the ovine endometrium, Biochem. J.237:797–805.

    PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Biochemistry, Medical College of Ohio, Toledo, Ohio, 43699, USA

    Melvyn S. Soloff

Authors
  1. Melvyn S. Soloff
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. School of Medicine, University of California, Los Angeles, Los Angeles, California, USA

    Mary E. Carsten  & Jordan D. Miller  & 

Rights and permissions

Reprints and permissions

Copyright information

© 1990 Plenum Press, New York

About this chapter

Cite this chapter

Soloff, M.S. (1990). Oxytocin Receptors in the Uterus. In: Carsten, M.E., Miller, J.D. (eds) Uterine Function. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-0575-0_12

Download citation

  • DOI: https://doi.org/10.1007/978-1-4613-0575-0_12

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4612-7873-3

  • Online ISBN: 978-1-4613-0575-0

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation