Abstract
PTH exerts effects on both the renal and extrarenal regulation of acidbase homeostasis. This brief revue will highlight the effects of the hormone on urinary acidification and on the whole body buffering of acid loads. Several balance studies will be cited to illustrate the integration of the renal and extrarenal effects of the peptide in the whole animal. Finally, I will discuss the modulating effect of metabolic acidosis on the anticalciuric action of PTH.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
F. P. Muldowney, D. V. Carroll, J, F. Donohoe, R. F. Freaney, Correction of renal bicarbonate wastage by parathyroidectomy, QuartJ Med. 40: 487 (1971).
M. L. Karlinsky, D. S. Sager, N. A. Kurtzman, V. P. G. Pillay, Effect of parathormone and cyclic adenosine monophosphate on renal bicarbonate reabsorption, AmerJ Physiol. 227: 1226 (1974).
M. Bichara, O. Mercier, M. Paillard, F. Leviel, Effects of parathyroid hormone on urinary acidification, AmerJ Physiol. 251: F444 (1986).
J. A. L. Arrüda, L. Nascimento, C. Westenfelder, N. A. Kurtzman, Effect of parathyroid hormone on urinary acidification, AmerJ Physiol. 232: F429 (1977).
O. Mercier, M. Bichara, M. Paillard, A. Prigent, Effects of parathyroid hormone on collecting duct hydrogen secretion, AmerJ Physiol. 251: F802 (1986).
A. S. Pollock, D. G Warnock, G. J. Strewler, Parathyroid hormone inhibition of Na+-H+antiporter activity in a cultured renal cell line, AmerJ Physiol. 250: F217 (1986).
D. S. Fraley and S. Adler, An extrarenal role for parathyroid hormone in the disposal of acute acid loads in rats and dogs, J Clin Invest. 63: 985 (1979)
N. E. Madias, C. A. Johns, S. M. Homer, Independence of the acute acid-buffering response from endogenous parathyroid hormone, AmerJ Physiol. 243: F141 (1982).
J. A. L. Arruda, V. Alla, H. Rubenstein, M. Cruz-Soto, S. Sabatini, D. C. Batlie, N, A. Kurtzman, Parathyroid hormone and extrarenal acid buffering, AmerJ Physiol. 239: F533, 1980.
J. A. L. Arruda, V. Alla, H. Rubenstein, M. Cruz-Soto, S. Sabatini, D. C. Batlle, N. A. Kurtzman, Metabolic and hormonal factors influencing extrarenal buffering of an acute acid load, Mineral Electrolyte Metab. 8: 36 (1982).
J. H. Licht, K. McVicker, Parathyroid-hormone-induced metabolic alkalosis in dogs, Mineral Electrolyte Metab. 8: 78 (1982).
H. N. Hulter, A. Sebastian, R. D. Toto, E. L. Bonner, Jr., L. P. Ilnicki, Renal and systemic acid-base effects of the chronic administration of hypercalcemia-producing agents: Calcitriol, PTH, and intravenous calcium, Kidney Internat. 21: 445 (1982).
H. N. Hulter, J. C. Peterson, Acid-base homeostasis during chronic PTH excess in humans. Kidney Internat. 28: 187 (1985).
H. N. Hulter, R. D. Toto, E. L. Bonner, Jr., L. P. Ilnicki, A. Sebastian, Renal and systemic acid-base effects of chronic hypo¬parathyroidism in dogs, AmerJ Physiol. 241: F495 (1981).
D. Batlle, K. Itsarayoungyuen, S. Hays, J. A. L. Arruda, N, A. Kurtzman, Parathyroid hormone is not anticalciuric during chronic metabolic acidosis, Kidney Internat. 22: 264 (1982).
A. Goulding, D. R. Campbell, Thyroparathyroidectomy exaggerates calciuric action of ammonium chloride in rats, AmerJ Physiol. 246: F54 (1984).
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1989 Plenum Press, New York
About this chapter
Cite this chapter
Kurtzman, N.A. (1989). PTH and Acid-Base Regulation. In: Massry, S.G., Fujita, T. (eds) New Actions of Parathyroid Hormone. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-0567-5_29
Download citation
DOI: https://doi.org/10.1007/978-1-4613-0567-5_29
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4612-7870-2
Online ISBN: 978-1-4613-0567-5
eBook Packages: Springer Book Archive