Abstract
The impact of molecular and cell biology on endocrinology, as on many other fields of biomedical science, has been immense over the last decade. Genes for most of the peptide hormones have been cloned and analyzed over the last three years; more recently, the difficult task of cloning hormone receptors has been accomplished at least for several hormonal systems. Development of bacterial or mammalian cell systems to express the cDNA and genes for hormones and receptors, coupled with oligonucleotide directed mutagenesis, is permitting wide exploration of structure/activity relations for peptide hormones in endocrine signaling. The techniques of peptide chemistry can now be combined with those of molecular biology to investigate in detail the contribution of primary structure to endocrine function.
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© 1989 Plenum Press, New York
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Potts, J.T. et al. (1989). Chemistry, Molecular Biology and Mode of Action of Parathyroid Hormone. In: Massry, S.G., Fujita, T. (eds) New Actions of Parathyroid Hormone. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-0567-5_2
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DOI: https://doi.org/10.1007/978-1-4613-0567-5_2
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