Parathyroid Hormone Receptors in Cultured Rat Vascular Smooth Muscle and Bovine Endothelial Cells

  • Yukio Hirata
  • Yasuyuki Takagi
  • Takuo Fujita


It has been reported that parathyroid hormone (PTH) causes a marked decrease in blood pressure in a variety of species1,2 and relaxes pre-contracted vascular strips from conduit- to resistance-type vessels 3,4,5 . Therefore, PTH may have direct action on the vascular tissues other than kidney and bone. However, little is known about the cellular mechanism of vascular action by PTH. To elucidate the mechanism of PTH action in the vasculature, we have attempted to identify and characterize vascular receptors for PTH in cultured rat vascular smooth muscle cells (VSMC) and bovine endothelial cells (EC) using 125I-labeled-synthetic amino-terminal fragment of human (h) PTH as radioligand.


Atrial Natriuretic Peptide Vasoactive Intestinal Peptide Atrial Natriuretic Factor Bovine Endothelial Cell Competitive Binding Study 
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Copyright information

© Plenum Press, New York 1989

Authors and Affiliations

  • Yukio Hirata
    • 1
    • 2
  • Yasuyuki Takagi
    • 1
    • 2
  • Takuo Fujita
    • 2
  1. 1.Hypertension DivisionNational Cardiovascular Cener Research InstituteOsakaJapan
  2. 2.Department of MedicineKobe University School of MedicineKobeJapan

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