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New Actions of Parathyroid Hormone pp 103–108Cite as

Parathyroid Hormone Receptors in Cultured Rat Vascular Smooth Muscle and Bovine Endothelial Cells

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Abstract

It has been reported that parathyroid hormone (PTH) causes a marked decrease in blood pressure in a variety of species1,2 and relaxes pre-contracted vascular strips from conduit- to resistance-type vessels 3,4,5 . Therefore, PTH may have direct action on the vascular tissues other than kidney and bone. However, little is known about the cellular mechanism of vascular action by PTH. To elucidate the mechanism of PTH action in the vasculature, we have attempted to identify and characterize vascular receptors for PTH in cultured rat vascular smooth muscle cells (VSMC) and bovine endothelial cells (EC) using 125I-labeled-synthetic amino-terminal fragment of human (h) PTH as radioligand.

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Author information

Authors and Affiliations

  1. Hypertension Division, National Cardiovascular Cener Research Institute, Osaka, 565, Japan

    Yukio Hirata & Yasuyuki Takagi

  2. Department of Medicine, Kobe University School of Medicine, Kobe, 650, Japan

    Yukio Hirata, Yasuyuki Takagi & Takuo Fujita

Authors
  1. Yukio Hirata
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  2. Yasuyuki Takagi
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  3. Takuo Fujita
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Editor information

Editors and Affiliations

  1. University of Southern California, Los Angeles, California, USA

    Shaul G. Massry

  2. Kobe University School of Medicine, Kobe, Japan

    Takuo Fujita

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© 1989 Plenum Press, New York

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Hirata, Y., Takagi, Y., Fujita, T. (1989). Parathyroid Hormone Receptors in Cultured Rat Vascular Smooth Muscle and Bovine Endothelial Cells. In: Massry, S.G., Fujita, T. (eds) New Actions of Parathyroid Hormone. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-0567-5_13

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  • DOI: https://doi.org/10.1007/978-1-4613-0567-5_13

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4612-7870-2

  • Online ISBN: 978-1-4613-0567-5

  • eBook Packages: Springer Book Archive

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