Parathyroid Hormone-Related Protein of Cancer: A Novel Gene Product with a PTH Protope

  • T. J. Martin
  • B. E. Kemp
  • J. M. Moseley
  • L. G. Raisz
  • L. J. Suva
  • W. I. Wood


The term humoral hypercalcemia of malignancy (HHM) describes patients with certain cancers in whom the blood calcium level is elevated, due to production by the cancer of some substance which acts generally upon the skeleton to increase bone resorption and upon the kidney to reduce calcium excretion (1). The condition is associated with a low plasma level of phosphorus and increased renal production of cyclic AMP (2). The tumors most commonly associated with this syndrome are squamous cell carcinoma of the lung, renal cortical carcinoma, other squamous cell cancers and some miscellaneous tumors.


Primary Hyperparathyroidism Squamous Cell Cancer Humoral Hypercalcemia Blood Calcium Level Phase High Pressure Liquid Chromatography 
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Copyright information

© Plenum Press, New York 1989

Authors and Affiliations

  • T. J. Martin
    • 1
  • B. E. Kemp
    • 1
  • J. M. Moseley
    • 2
  • L. G. Raisz
    • 2
  • L. J. Suva
    • 3
  • W. I. Wood
    • 3
  1. 1.Dept. of Medicine, Repatriation General Hospital, eidelbergUniversity of MelbourneAustralia
  2. 2.Health Center, Conn.Universify of Conn.USA
  3. 3.Genentech Inc.San FranciscoUSA

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