Abstract
In thyroid tissue, an effect of thyrotropin (TSH) was shown to affect the turhover rates of phospholipids (Morton and Schwartz, 1953) and that of phosphatidylinositol in particular (Freinkel, 1957) several years before the same hormone was found to stimulate cyclic AMP accumulation (Klainer et al., 1962). However, progress in the field of cyclic AMP biochemistry was so rapid, that there was a tendency to consider cyclic AMP to be the sole mediator of all the effects of TSH (Pastan and Macchia, 1967). But, the “phospholipid effect” of TSH was clearly demonstrated to be cyclic AMP independent in 1970 (Jacquemin and Haye, 1970; Scott et al., 1970). This was followed by the discovery of a TSH-dependent cytosolic phospholipase C acting on phosphatidylinositol (Haye and Jacquemin, 1974), and of the transient formation of diacylglycerol (Igarashi and Kondo, 1980). These observations correlate well with the first “phosphatidylinositol cycle” proposed by Michell (1975).
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References
Alemany, S., Mato, J. M. and Stralfors, P. 1987, Phospho-dephospho-control by insulin is mimicked by a phospho-oligosaccharide in adipocytes Nature, 330, 77
Aublin, J. L., Lambert, B., Haye, B., Jacquemin, C. and Champion, S. 1986, Relationships between the GTP content and the TSH-stimulated adenylate cyclase activity of cultured thyroid cells. Mol. Cell. Endocrinol., 45:11
Berridge, M. J., 1983, Rapid accumulation of inositol trisphosphate reveals that agonists hydrolyse polyphosphoinositides instead of phosphatidylinositol. Biochem. J., 212:849
Bone, E. A., Ailing, D. W. and Grollman, E. F. 1986, Norepinephrine and thyroid-stimulating hormone induce inositol phosphate accumulation in FRTL-5 cells, Endocrinology, 119:2193
Breton, M. F., Haye, B., Omri, B., Jacquemin, C. and Pavlovic-Hournac, M. 1988, Decrease in cAMP-dependent protein kinase activity in suspension cultures of porcine thyroid cells exposed to TSH or forskolin. Mol. Cell. Endocrinol., 55:243
Cailla, H., Racine-Weisbuch, H. and Delaage, M. 1973, Adenosine 3’,5’ cyclic monophosphate assay at 10-15 mole level. Anal. Biochem. 56:396
Freinkel, N. 1957, Pathways of thyroidal phosphorus metabolism: the effect of pituitary thyrotropin upon the phospholipids of the sheep thyroid gland. Endocrinology, 61:448
Gerard, C., Haye, B. and Jacquemin, C. 1981, Effects of arachidonate on cultured pig thyroid cells and their stimulation by thyrotropin. FEBS Letters, 132:23
Gerard, C., Haye, B., Jacquemin, C. and Mauchamp, J. 1982, Chronic and acute effects of thyrotropin on phosphatidylinositol turnover in cultured porcine thyroid cells. Biochem. Biophys. Acta, 710:359
Graff, I., Mockel, J., Laurent, E., Erneux, C. and Dumont, J.E. 1987, Carbachol and sodium fluoride, but not TSH, stimulate the generation of inositol phosphates in the dog thyroid. FEBS Letters, 210:204
Haye, B. and Jacquemin, C. 1974, Stimulation par la thyréostimuline de la production de l’inositol 1–2 phosphate cyclique. Biochimie, 56:1283
Haye, B., Aublin, J. L., Champion, S., Lambert, B. and Jacquemin, C. 1985 Chronic and acute effects of forskolin on isolated thyroid cell metabolism. Mol. Cell, Endocrinol., 43:41
Igarashi, Y. and Kondo, Y. 1980, Acute effect of thyrotropin on phosphatidylinositol degradation and transient accumulation of diacylglycerol in isolated thyroid follicles. Biochem. Biophys. Res. Commun., 97:759
Igarashi, Y. and Chambaz, E. M. 1987, A novel inositol glycophospholipid (IGPL) and the serum dependence of its metabolism in bovine adrenocortical cells. Biochem. Biophys. Res. Commun., 145:249
Jacquemin, C. and Haye, B. 1970, Action de la TSH sur le métabolisme des phospholipides thyroidiens in vitro. Effet biphasique non reproduit par cAMP et DBC. Bull. Soc. Chim. Biol., 52:153
Kelly, K. L., Mato, J. M., Merida, I. and Jarett, L. 1987a, Glucose transport and antilipolysis are differentially regulated by the polar head group of an insulin-sensitive glycophospholipid. Proc. Natl. Acad. Sci. USA, 84:6404
Kelly, K. L., Merida, I., Wong, E. H. A., DiCenzo, D. and Mato, J. M. 1987b, A phospho-oligosaccharide mimics the effect of insulin to inhibit isoproterenol-dependent phosphorylation of phospholipid methyltransferase in isolated adipocytes. J. Biol. Chem., 262:15285
Klainer, L. M., Chi, Y. M., Friedberg, S. L., Rall, T. W., and Sutherland, E. W. (1962). Adenyl cyclase: IV The effect of neurohormones on the formation of adenosine 3’,5’-phosphate by preparations from brain and other tissues. J. Biol. Chem. 237:1239.
Lambert, B. and Jacquemin, C. 1983, Restoration by insulin of the responsiveness of stimulated adipocytes to adenosine. FEBS Letters, 155:31
Laurent, E., Mockel, J., Van Sande, J., Graff, I. and Dumont, J. E. 1987, Dual activation by thyrotropin of the phospholipase C and cyclic AMP cascades in human thyroid. Mol. Cell. Endocrinol., 52:273
Mato, J. M., Kelly, K. L., Abler, A. and Jarett, L., 1987, Identification of a novel insulin-sensitive glycophospholipid from H35 hepatoma cells. J. Biol. Chem., 262:2131
Merida, I., Corrales, F. J., Clemente, R., Ruiz-Albusac, J. M., Villalba, M. and Mato, J.M. 1983, Different phosphorylated forms of an insulin-sensitive glycosylphosphatidylinositol from rat hepatocytes. FEBS Letters, 155:31
Michell, R. H., 1975, Inositol phospholipids and cell surface receptor function. Biochim. Biophys. Acta. 415:81
Morton, M. E. and Schwartz, J. R. 1953, The stimulation in vitro of phospholipid synthesis in thyroid tissue by thyrotropic hormone Science, 117:103
Nishizuka, Y. 1984, The role of protein kinase C in cell surface signal transduction and tumour promotion. Nature, 308:693
Pastan, I. and Macchia, V. 1967 Mechanism of thyroid stimulating hormone action: studies with dibutyryl 3’,5’-adenosine monophosphate and lecithinase C. J. Biol. Chem., 242:5757
Pekonen, F. and Weintraub, B. D. 1980, Salt-induced exposure of high affinity thyrotropin receptors on human and porcine thyroid membranes. J. Biol. Chem., 255:8121
Rodbell, M. 1964, Metabolism in isolated fat cells. I. Effects of hormones on glucose metabolism and lipolysis. J. Biol. Chem., 239:375
Saltiel, A. R. and Cuatrecasas, P. 1986, Insulin stimulates the generation from hepatic plasma membranes of modulators derived from an inositol glycolipid. Proc. Natl. Acad. Sci. USA, 83:5793
Saltiel, A. R., Fox, J. A., Sherline, P. and Cuatrecasas, P, 1986, Insulin generates an enzyme modulator from hepatic plasma membranes: regulation of adenosine 3’,5’-monophosphate phosphodiesterase, pyruvate dehydrogenase, and adenylate cyclase. Science, 233:967
Saltiel, A. R., 1987 Insulin generates an enzyme modulator from hepatic plasma membranes: regulation of adenosine 3’,5’-monophosphate phosphodiesterase, pyruvate dehydrogenase, and adenylate cyclase. Endocrinology, 120:967
Scott, T. W., Freinkel, N., Klein, J. M. and Nitzan, M. 1970, Metabolism of phospholipids, neutral lipids and carbohydrates in dispersed porcine thyroid cells: comparative effects of pituitary thyrotropin and dibutyryl 3’,5’-adenosine monophosphate on the turnover of individual phospholipids in isolated cells from pig thyroid. Endocrinology, 87:854
Taguchi, M. and Field, J. B. 1988. Effects of thyroid-stimulating hormone, carbachol, norepinephrine, and adenosine 3’,4’-monophosphate on polyphosphatidylinositol phosphate hydrolysis in dog thyroid slices. Endocrinology, 123:2019
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© 1990 Plenum Press, New York
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Martiny, L., Thuilliez, B., Lambert, B., Antonicelli, F., Jacquemin, C., Haye, B. (1990). Control by TSH of the Production by Thyroid Cells of an Inositol Phosphateglycan, Putative Mediator of the cAMP-Independent Effects in the Gland. In: Vanderhoek, J.Y. (eds) Biology of Cellular Transducing Signals. GWUMC Department of Biochemistry Annual Spring Symposia. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-0559-0_41
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DOI: https://doi.org/10.1007/978-1-4613-0559-0_41
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