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The Orchestration of Stimulatory Signals for Secretion in Rat Basophilic Leukemia (RBL-2H3) Cells

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Biology of Cellular Transducing Signals

Abstract

Cells that express high affinity receptors for immunoglobulin E (IgE) on their surface, when stimulated with antigen, release substances that cause a wide range of antigen-mediated disorders, some of which are merely annoying but afflict a large proportion of the population and others of which are disabling and sometimes fatal. Obviously an understanding of the cascade of events that lead to release of inflammatory mediators from these cells would be useful from the viewpoint of treating these disorders. These cells, however, have become in themselves interesting experimental models for the study of stimulus-secretion coupling mechanisms.

1Recipient of a CAPES Fellowship from the Ministry of Education, Brazi l.

2Recipient of a Scholarship from the Rotary Found. of Rotary Intl.

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Authors and Affiliations

  1. Laboratory of Chemical Pharmacology, National Heart Lung, and Blood Inst., NIH, Bethesda, MD, 20892, USA

    Michael A. Beaven, Russell Ludowyke, Heloisa M. S. Gonzaga, Dolores Collado-Escobar, Michihiro Hide & Hydar Ali

Authors
  1. Michael A. Beaven
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  2. Russell Ludowyke
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  3. Heloisa M. S. Gonzaga
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  4. Dolores Collado-Escobar
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  5. Michihiro Hide
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  6. Hydar Ali
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Editors and Affiliations

  1. The George Washington University Medical Center, Washington, D.C., USA

    Jack Y. Vanderhoek

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© 1990 Plenum Press, New York

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Beaven, M.A., Ludowyke, R., Gonzaga, H.M.S., Collado-Escobar, D., Hide, M., Ali, H. (1990). The Orchestration of Stimulatory Signals for Secretion in Rat Basophilic Leukemia (RBL-2H3) Cells. In: Vanderhoek, J.Y. (eds) Biology of Cellular Transducing Signals. GWUMC Department of Biochemistry Annual Spring Symposia. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-0559-0_32

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  • DOI: https://doi.org/10.1007/978-1-4613-0559-0_32

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4612-7866-5

  • Online ISBN: 978-1-4613-0559-0

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