Abstract
Substantial progress has been made over the last several years in understanding leukotriene (LT)D4 receptors and the signal transduction process (Crooke et al., 1988; Crooke et al., 1989). LTD4 interacts with highly selective, specific receptors for LTD4 which are located on the plasma membrane and which have been characterized in guinea pig lung, guinea-pig heart, human lung, rat basophilic leukemia cells, human monocytic leukemia U937 cells, human mesangial cells and sheep tracheal smooth muscle cells. The receptors are coupled through guanine nucleotide binding proteins (G proteins) to a phosphatidylinositol-specific phospholipase C (PIP2-PLC). In U937 cells, LTD4 receptors interact with at least two types of G proteins, one being sensitive and the other insensitive to pertussis toxin. LTD4-induced activation of PIP2-PLC results in increased formation of inositol phosphates (IP), diacylglycerol (DAG) and transient increases in intracellular calcium ([ca2+]i). Subsequently, protein kinase C is activated, phosphatidyl choline specific phospholipase A2 is activated, enhancing the release of arachidonic acid and its metabolism to various products (Crooke et al., 1989).
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References
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© 1990 Plenum Press, New York
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Sarau, H.M., Tzimas, M.N., Foley, J.J., Winkler, J.D., Kennedy, M.E., Crooke, S.T. (1990). Leukotriene D4 Increases the Metabolism of an Inositol Tetrakisphosphate - Containing Phospholipid in U937 Cells. In: Vanderhoek, J.Y. (eds) Biology of Cellular Transducing Signals. GWUMC Department of Biochemistry Annual Spring Symposia. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-0559-0_24
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DOI: https://doi.org/10.1007/978-1-4613-0559-0_24
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