Inositol 1,4,5-Trisphosphate and Inositol 1,3,4,5-Tetrakisphosphate: Two Second Messengers in a Duet of Calcium Regulation

  • Robin F. Irvine
Part of the GWUMC Department of Biochemistry Annual Spring Symposia book series (GWUN)

Abstract

In the “dual second messenger” hypothesis incorporating diacylglycerol and inositol(1,4,5)trisphosphate (Berridge, 1984),it is axiomatic that Ins(1,4,5)P-3 is the link between inositides and Ca2+ (Barridge & Irvine, 1984); However, it is now emerging that this hypothesis may be incomplete, and that there is a third second messenger derived from inositides whose presence was not even remotely suspected until recently. The fact that its very existence was unknown, and the rather enigmatic nature of its function (discussed in some detail below), have together delayed for some years its entry into the picture. But now, as the mist clears, it is emerging that Ins(1,4,5)P-3 is only one half of the inositol phosphate messenger story. It is on the other half, Inositol 1,3,4,5-tetrakisphosphate, that this short review will focus.

Keywords

Hydrolysis Lymphoma Retina Histamine Cytosol 

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Copyright information

© Plenum Press, New York 1990

Authors and Affiliations

  • Robin F. Irvine
    • 1
  1. 1.AFRC Institute of Animal Physiology and Genetics ResearchBabrahamUK

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