Inositol 1,4,5-Trisphosphate and Inositol 1,3,4,5-Tetrakisphosphate: Two Second Messengers in a Duet of Calcium Regulation
In the “dual second messenger” hypothesis incorporating diacylglycerol and inositol(1,4,5)trisphosphate (Berridge, 1984),it is axiomatic that Ins(1,4,5)P-3 is the link between inositides and Ca2+ (Barridge & Irvine, 1984); However, it is now emerging that this hypothesis may be incomplete, and that there is a third second messenger derived from inositides whose presence was not even remotely suspected until recently. The fact that its very existence was unknown, and the rather enigmatic nature of its function (discussed in some detail below), have together delayed for some years its entry into the picture. But now, as the mist clears, it is emerging that Ins(1,4,5)P-3 is only one half of the inositol phosphate messenger story. It is on the other half, Inositol 1,3,4,5-tetrakisphosphate, that this short review will focus.
KeywordsInositol Phosphate Acrosome Reaction Inositol Trisphosphate Inositol Phosphate Metabolism Messenger Role
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