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Novel Endogenous ADP-Ribosylations of Proteins in Transformed Cells: Effects of Cellular Transformation and Differentiation

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Book cover Biology of Cellular Transducing Signals

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Abstract

ADP-ribosylation is a post-translational modification of proteins that utilizes NAD1 as a donor for the modification grohp (Ueda and Hayaishi, 1985). The reaction involves enzymatic transfer of the ADP-ribose moiety of NAD to specific acceptor amino acids on the target protein; nicotinamide being the released product of this reaction. ADP-ribosylation reactions are broadly classified into mono- and poly(ADPribosyl) ation on the basis of ADP-ribose chain length. However, there are other differences between the two groups. Mono(ADPribosyl) ations generally occur on the side-chain nitrogen atom of the acceptor amino acid, and depending upon this acceptor, can be classified as types A (arginine), C (cysteine) and D (diphthamide) respectively (Moss et al., 1980; Tanuma et al., 1988; Sayhan et al., 1986). On the contrary, poly(ADP-ribosyl) ation starts on the carboxyl groups and forms oglycosidic linkages on glutamic acid residues within the target protein. In some cases (e.g. in histone H1), COOH-terminal lysine may also be the site for poly(ADP-ribosyl)ation (Ogata et al., 1980).

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Authors and Affiliations

  1. Department of Pharmacology, University of Connecticut Health Center, Farmington, CT, 06032, USA

    Harjit S. Banga & Maurice B. Feinstein

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  1. Harjit S. Banga
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  2. Maurice B. Feinstein
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  1. The George Washington University Medical Center, Washington, D.C., USA

    Jack Y. Vanderhoek

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© 1990 Plenum Press, New York

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Banga, H.S., Feinstein, M.B. (1990). Novel Endogenous ADP-Ribosylations of Proteins in Transformed Cells: Effects of Cellular Transformation and Differentiation. In: Vanderhoek, J.Y. (eds) Biology of Cellular Transducing Signals. GWUMC Department of Biochemistry Annual Spring Symposia. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-0559-0_21

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  • DOI: https://doi.org/10.1007/978-1-4613-0559-0_21

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4612-7866-5

  • Online ISBN: 978-1-4613-0559-0

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