Abstract
The human hormone granulocyte-macrophage colony-stimulating factor (GM-CSF), which is released by activated T lymphocytes, endothelium and fibroblasts, is an important stimulus for the proliferation of erythroid and myelomonocytic stem cells in vitro (Golde and Gasson, 1988). GM-CSF is also an important in vitro regulator of granulopoiesis and neutrophil function. It induces significant leukocytosis and shortens the period of neutropenia following bone marrow transplantation,and in patients with AIDS, it increases the number of neutrophils, eosinophils and monocytes (Groopman et. al., 1987; Donahue et. al., 1986; Metcalf, 1985; Golde and Gasson, 1988). The addition of GM-CSF to mature human neutrophils primes these cells to subsequent stimulation by chemotactic factors such as fMet-Leu-Phe and thus it plays an important role in the host defense (Weisbart et. al., 1987; Dahinden et. al., 1988, Sullivan et. al., 1987; Naccache et. al., 1988; Weisbart, et. al., 1986; Mege et. al., 1989). The responses which are primed include oxidative burst, phagocytosis, arachidonic acid release and others. In addition to the priming of neutrophils, the addition of GM-CSF to human neutrophils produces on its own some responses (Coffey et. al., 1988; Gomez-Cambronero et. al., 1989; McColl et. al., 1989; Mege et. al., 1989; Nathan, 1989).
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References
Arnaout, M. A. Wang, E. A., Clark, S. C., and Sieff, C. A., 1986, Human recombinant granulocyte-macrophage colony-stimulating factor increases cell-to-cell adhesion and surface expression of adhesion-promoting surface glycoproteins on mature granulocytes. J. Clin. Invest., 78: 597.
Bishop, J.M., 1983, Cellular oncogenes and retroviruses. Annu. Rev. Biochem., 52: 301.
Coffey, R. G., Oavis, J. S., and Djeu, J. Y., 1988, Stimulation of guanylate cyclase activity and reduction of adenylate cyclase activity by granulocyte-macrophage colony-stimulating factor in human blood neutrophils. J. Immunol. 140: 2695.
Colotta, F., Wang, J. M., Polentaruti, N., and Mantovani, A., 1987, Expression of c-fos protooncogene in normal human peripheral blood granulocytes. J. Exp. Med., 165: 1224.
Dahinden, C. A., Zingg, J., Maly, F. E., and DeWeck, A. L., 1988, Leukotriene production in human neutrophils primed by recombinant human granulo-cyte macrophage colony-stimulating factor and stimulated with the complement component CSa and FMLP as second signals. J. Exp. Med., 167: 1281.
Dipersio, J., Billing, P., Kufman, S., Egresady, P., Williams, R. E., and Gasson, J. C., 1988, Characterization of the human granulocyte- macrophage colony-stimulating factor (GM-CSF) receptor, J. Biol. Chem., 263: 1834.
Donahue, R. E., Karlsson, S., Clark, S., Anderson, W. F., and Nienhuis, A. W., 1986, Recombinant human GM-CSF accelerates neutrophil and platelet recovery following autologous bone marrow transplantation. Blood, 68: 281a.
Gilman, A. G., 1987, G-proteins: Transducers of receptor-generated signals, Ann. Rev. Biochem., 56: 615.
Golde, D. W., and Gasson, J. C., 1988, Hormones that stimulate the growth of blood cells, Scientific American, 259: 62.
Gomez-Cambronero, J., Yamazaki, M., Metwally, F., Molski, T. F. P., Bonak, V. A., Huang, C.-K., Becker, E. L., and Sha’afi, R. I., 1989, Granulocyte-macrophage colony-stimulating factor and human neutrophils: Role of guanine-nucleotide regulatory proteins, Proc. Natl. Acad. Sci. U. S. A., in press.
Groopman, J. E., Mitsuyasu, R. T., Deleo, M. J., Oette, D. H., and Golde, D. W., 1987, Effect of recombinant human granulocyte-macrophage colony-stimulation factor on myelopoiesis in the acquired immunodeficiency syndrome. N. Engl. J. Med., 317: 593.
Lopez, A., Williamson, J., Gamble, J., Begley, G., Harlan, J., Klebanoff, S., Waltersdorph, A., Wong, G. G., Clark, S. C., and Vadas, M., 1986, Recombinant human granulocyte-macrophage colony-stimulating factor stimulates in vitro mature human neutrophil and eosinophil function, surface receptor expression and survival, J. Clin. Invest., 78: 1220.
McColl, S. R., Kresi, C., Di Persio, J. F., Borgeat, P., and Naccache, P. H., 1989, Involvement of guanine nucleotide binding proteins in neutrophil activation and priming by GM-CSF. Blood, 73: 588.
Mege, J. L., Gomez-Cambronero, J., Molski, T. F. P., Becker, E. L., and Sha’afi, R. I., 1989, Effect of granulocyte-macrophage colonly-stimulating factor on superoxide produciton in cytoplasts and intact human neutrophils: Role of protein kinase C and G-proteins. J. Leuk. Biol., In press.
Metcalf, D., 1985, The granulocyte-macrophage colony-stimulating factors. Science, 229: 16.
Morla, A. O., Schreurs, J., Miyajima, A., and Wang, J. Y. J., 1988, Hematopoietic growth factors activate the tyrosine phosphorylation of distinct sets of proteins in interleukin-3-dependent murine cell line, Mol. Cell. Biol., 8: 2214.
Naccache, P. H., Molski, M. M., Volpi, M., Becker, E. L., and Sha’afi, R. I., 1985, Unique inhibitory profile of platelet activating factor induced calcium mobilization, polyphosphoinositide turnover and granule enzyme secretion in rabbit neutrophils towards pertussis toxin and phorbol esters. Biochem. Biophys. Res. Commun., 130: 677.
Naccache, P. H., Faucher, N., Borgeat, P. J. C., and Depersio, J. F., 1988, Granulocyte-macrophage colony-stimulating factor modulates the excitation-response coupling sequence in human neutrophils, J. Immunol., 140: 3541.
Nathan, C.F., 1989, Respiratory burst in adherent human neutophîls: Triggering by colony-stimulating factors CSF-GM and CSF-G., Blood, 73: 301.
Sha’afi, R. I. and Molski, T. F. P., 1988, Activation of the neutrophils, Progress in Allergy, 42: 1.
Sullivan, R., Griffin, J. D., Simons, E. R., Schafer, A. I., Meshulam, T., Fredette, J. P., Maas, A. K., Gadenne, A. S., Leavitt, J. L., and Melnick, D. A., 1987, Effects of recombinant human granulocyte and macrophage colony-stimulating factors on signal transduction pathways in humangranulocytes. J. Immunol., 139: 3422.
Verghese, M. W., Charles, L., Jakoi, L., Dillon, S. B., and Snyderman, R., 1987, Role of a guanine nucleotide regulatory protein in the activation of phospholipase C by different chemoattractants. J. Immunol., 138: 4374.
Weisbart, R. H., Golde, D. W., and Gasson, J. C., 1986, Biosynthetic human GM-CSF modulates the number and affinity of neutrophil fMet-Leu-Phe receptors, J. Immunol., 137: 3584.
Weisbart, R. H., Kwan, L., Golde, D. W., and Gasson, J. C., 1987, Human GM-CSF primes neutrophils for enhanced oxidative metabolism in response to the major physiologic chemoattractants, Blood, 69: 18.
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© 1990 Plenum Press, New York
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Sha’afi, R.I., Gomez-Cambronero, J., Yamazaki, M., Durstin, M., Molski, T.F.P., Huang, CK. (1990). Activation of Human Neutrophils by Granylocyte-Macrophage Colony-Stimulating Factor: Role of Guanine-Nucleotide Binding Proteins. In: Vanderhoek, J.Y. (eds) Biology of Cellular Transducing Signals. GWUMC Department of Biochemistry Annual Spring Symposia. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-0559-0_16
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DOI: https://doi.org/10.1007/978-1-4613-0559-0_16
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