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Electrostimulation of Cell Metabolism and Proliferation

  • Chapter
Charge and Field Effects in Biosystems—2

Abstract

Besides electroporation and electrofusion of cells by single pulses of high field strength a lot of effects on cell metabolism and proliferation have been detected caused by pulsating (pulsatile) electromagnetic induced currents (PEMIC) or direct influence of alternating currents (DAC) on cell suspension or.tissues. These electrostimulations mostly increase the basic syntheses of ATP, DNA, m-RNA, proteins and the membrane transport. However, a systematic research and theoretical explanations are still in the beginning and some contradictions can be found in literature, too.

In order to extend applications of electrostimulations of metabolic reactions we started PEMIC and DAC experiments on yeast and Streptomyces strains under tariable conditions will be presented on the

  • CO2 release from Sacch. cerev.,

  • proliferation rate of Sacch. cerev., fermentation processes of Streptomyces,

  • formation of anthracycline chromophores.

Finally some relations between PEMIC, DAC and single pulses will be discussed showing not only the powerful tool of electric fields in basic cell biology on one hand, but mentioning also the potentially dangerous influence on human beings on the other.

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Author information

Authors and Affiliations

  1. Central Institute of Microbiology and Exptl. Therapy, Dept. of Biophysical Chemistry, Acad. of Sci. of the GDR, DDR-6900, Jena, Germany

    Hermann Berg

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  1. Hermann Berg
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Editor information

Editors and Affiliations

  1. Virginia Commonwealth University, Richmond, Virginia, USA

    M. J. Allen , S. F. Cleary  & F. M. Hawkridge ,  & 

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© 1989 Plenum Press, New York

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Berg, H. (1989). Electrostimulation of Cell Metabolism and Proliferation. In: Allen, M.J., Cleary, S.F., Hawkridge, F.M. (eds) Charge and Field Effects in Biosystems—2. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-0557-6_27

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  • DOI: https://doi.org/10.1007/978-1-4613-0557-6_27

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4612-7865-8

  • Online ISBN: 978-1-4613-0557-6

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