Abstract
Electron and ion transports, reductions and oxidations are common chemical reactions in cellular energy transductions. These reactions involve charges and are, thus, susceptible to influence by an electric field. Many laboratories have recently discovered that electric fields in certain ranges and frequencies can stimulate DNA, RNA, and protein biosyntheses (Blank & Findl, 1987; Cleary, 1987). Enhancement and suppression of enzyme activities have also been reported (Blank & Findl, 1987). This paper will discuss our experiments in which electric fields of defined frequency and amplitude were used to activate mitochondrial ATPases of rat liver and beef heart and the (Na,K)-ATPase of human erythrocytes (see Tsong et al., 1989 for references). Electroconformational Coupling which we proposed earlier (Tsong & Astumian, 1986, 1987, 1988; Tsong et al., 1989a; Tsong, 1989; Astumian et al., 1989) will be used to explain these results. The following two papers (Astumian et al. & Robertson et al. in this volume) will elaborate the concept in greater details and analyze some simple reaction mechanisms which are relevant to the present discussion. We will also show that non-linear effects arising from the coulombic interaction of membrane proteins and an electric field are responsible for the many observed effects.
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References
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Tsong, T.Y., Astumian, R.D. (1989). Charge-Field Interactions in Cell Membranes and Electroconformational Coupling: Transduction of Electric Energy by Membrane ATPases. In: Allen, M.J., Cleary, S.F., Hawkridge, F.M. (eds) Charge and Field Effects in Biosystems—2. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-0557-6_17
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DOI: https://doi.org/10.1007/978-1-4613-0557-6_17
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