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Antioxidant Nutrients and Immune Functions pp 19–33Cite as

The Role of Antioxidants in Modulating Neutrophil Functional Responses

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Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 262))

Abstract

Prior to phagocytic stimulation the neutrophil consumes only small amounts of oxygen and relies primarily on anaerobic glycolysis for energy, a finding consistent with the paucity of mitochondria in the cells (Cheson et al., 1977). Within seconds after stimulation, however, the neutrophil activates a specialized pathway that results in a 100-fold increase in oxygen consumption (Root and Metcalf, 1977). This pathway culminates in the reaction in which molecular oxygen is reduced to superoxide (O2-). The superoxide in turn undergo further reactions to form toxic derivatives such as hydrogen peroxide (H2O2), hydroxyl radical (·OH), organic oxygen radicals, and hypochlorite ion (HOCl), which are then used by the cell to destroy ingested microorganisms (Babior and Crowley, 1983; Tauber et al., 1983). Massive increases in oxygen consumption and oxygen radical production are referred to as the respiratory burst.

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Author information

Authors and Affiliations

  1. Division of Pediatric Hematology/Oncology CS Mott Childrens Hospital, University of Michigan, P.O. Box 0238, Ann Arbor, MI, 48109, USA

    Laurence A. Boxer

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  1. Laurence A. Boxer
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Editors and Affiliations

  1. Hoffmann LaRoche, Inc., Nutley, New Jersey, USA

    Adrianne Bendich

  2. Agricultural Research Service, USDA, NADC, Ames, Iowa, USA

    Marshall Phillips

  3. Colorado State University, Fort Collins, Colorado, USA

    Robert P. Tengerdy

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© 1990 Plenum Press, New York

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Boxer, L.A. (1990). The Role of Antioxidants in Modulating Neutrophil Functional Responses. In: Bendich, A., Phillips, M., Tengerdy, R.P. (eds) Antioxidant Nutrients and Immune Functions. Advances in Experimental Medicine and Biology, vol 262. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-0553-8_3

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  • DOI: https://doi.org/10.1007/978-1-4613-0553-8_3

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4612-7863-4

  • Online ISBN: 978-1-4613-0553-8

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