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The F0F1 H+-ATP Synthase of Mitochondria

  • Chapter
Organelles in Eukaryotic Cells

Abstract

The H+-ATP synthase complex of coupling membranes (mitochondrial membrane, plasma membrane of bacteria, thylakoid membrane of chloroplasts) (E.C.3.6.1.34) is a key enzyme in eukaryotes and prokaryotes, being responsible for ATP synthesis supported by the protonmotive force (PMF) generated in these membranes by redox or photoredox systems (1,2). To give an example of its role in humans, an adult with a daily energy need of around 3.000 Kcal utilizes ≈200 Kg of ATP. About 90% of this amount of ATP turning over in our cells — they are practically impermeable to ATP (and ADP)- is, under normal conditions, synthesized from ADP and Pi by the H+-ATP synthase of mitochondria.

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Author information

Authors and Affiliations

  1. Institute of Medical Biochemistry and Chemistry, University of Bari, Bari, Italy

    Sergio Papa

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  1. Sergio Papa
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Editors and Affiliations

  1. University of Amsterdam, Amsterdam, The Netherlands

    Joseph M. Tager

  2. University of Bern, Bern, Switzerland

    Angelo Azzi

  3. University of Bari, Bari, Italy

    Sergio Papa  & Ferruccio Guerrieri  & 

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© 1989 Plenum Press, New York

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Papa, S. (1989). The F0F1 H+-ATP Synthase of Mitochondria. In: Tager, J.M., Azzi, A., Papa, S., Guerrieri, F. (eds) Organelles in Eukaryotic Cells. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-0545-3_2

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  • DOI: https://doi.org/10.1007/978-1-4613-0545-3_2

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4612-7859-7

  • Online ISBN: 978-1-4613-0545-3

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