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Conversion Induced by Transforming Growth Factors α and β: The Role of “Wound Hormones” in Multistage Skin Carcinogenesis

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Biochemistry of Chemical Carcinogenesis

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Abstract

The induction of papillomas (and carcinomas) in mouse skin can be experimentally subdivided into the stages initiation, conversion and promotion While initiation is most probably related to gene mutation, conversion is required to render initiated skin sensitive to the tumor promoting effect of agents which induce hyperplastic transformation of skin and sustained epidermal hyperplasia. Traditionally, conversion and promotion are achieved by phorbol ester treatment. Conversion can also be affected by mechanical skin wounding. It is shown that a combined injection of two putative “wound hormones”, i.e. TGFα and TGFβ, converts initiated mouse skin to a promotable state. These results indicate a close relationship between the wound response and skin tumor development.

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Author information

Authors and Affiliations

  1. Institute of Biochemistry, German Cancer Research Center, Im Neuenheimer Feld 280, D - 6900, Heidelberg, Germany

    Friedrich Marks & Gerhard Fürstenberger

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  1. Friedrich Marks
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  2. Gerhard Fürstenberger
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Editors and Affiliations

  1. University of York, York, UK

    R. Colin Garner

  2. Research Institute for Tuberculosis and Respiratory Diseases, Prague, Czechoslovakia

    Jan Hradec

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© 1989 Plenum Press, New York

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Marks, F., Fürstenberger, G. (1989). Conversion Induced by Transforming Growth Factors α and β: The Role of “Wound Hormones” in Multistage Skin Carcinogenesis. In: Garner, R.C., Hradec, J. (eds) Biochemistry of Chemical Carcinogenesis. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-0539-2_5

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  • DOI: https://doi.org/10.1007/978-1-4613-0539-2_5

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4612-7856-6

  • Online ISBN: 978-1-4613-0539-2

  • eBook Packages: Springer Book Archive

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