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Conversion Induced by Transforming Growth Factors α and β: The Role of “Wound Hormones” in Multistage Skin Carcinogenesis

  • Friedrich Marks
  • Gerhard Fürstenberger

Abstract

The induction of papillomas (and carcinomas) in mouse skin can be experimentally subdivided into the stages initiation, conversion and promotion While initiation is most probably related to gene mutation, conversion is required to render initiated skin sensitive to the tumor promoting effect of agents which induce hyperplastic transformation of skin and sustained epidermal hyperplasia. Traditionally, conversion and promotion are achieved by phorbol ester treatment. Conversion can also be affected by mechanical skin wounding. It is shown that a combined injection of two putative “wound hormones”, i.e. TGFα and TGFβ, converts initiated mouse skin to a promotable state. These results indicate a close relationship between the wound response and skin tumor development.

Keywords

Epidermal Cell Phorbol Ester Mouse Skin Wound Response NMRI Mouse 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Deelman, H. T. (1924) Z. Krebsforsch., 21, 220–226CrossRefGoogle Scholar
  2. 2.
    Hennings, H. and Boutwell, R. K. (1970) Cancer Res., 30, 312–325PubMedGoogle Scholar
  3. 3.
    Clark-Lewis, I. and Murray, A. W. (1978) Cancer Res., 38, 494–497PubMedGoogle Scholar
  4. 4.
    Argyris, R. S. (1986) CRC Crit. Rev. Toxicol., 14, 211–237CrossRefGoogle Scholar
  5. 5.
    Hasegawa, R., St. John, M., Tibbels, S. and Cohen, S. (1987) J. Invest. Dermatol., 88, 652–656PubMedCrossRefGoogle Scholar
  6. 6.
    Haddow, A. (1972) Adv. Cancer Res., 16, 181–234PubMedCrossRefGoogle Scholar
  7. 7.
    Marks, R. (1988) Pathology Res. Pract., 182, 831–848Google Scholar
  8. 8.
    Sporn, M. B. and Roberts, A. B. (1986) J. Clin. Invest., 78, 329–332PubMedCrossRefGoogle Scholar
  9. 9.
    Marks, F., Furstenberger, G., Ganss, M., Richter, K. H. and Seemann, D. (1983) Brit. J. Dermatol., 109, Suppl. 25, 18–21Google Scholar
  10. 10.
    Bertsch, S. and Marks, F. (1974) Cancer Res., 34, 3283–3288PubMedGoogle Scholar
  11. 11.
    Bertsch, S. and Marks, F. (1978) Cell Tissue Kinet., 11, 651–658PubMedGoogle Scholar
  12. 12.
    Gilmour, S. K., Verma, A.K., Madara, T. and O’Brien, T.G. (1987) Cancer Res., 47, 1221–1225PubMedGoogle Scholar
  13. 13.
    Rose-John, S., Furstenberger, G., Krieg, P., Besemfelder, E., Rincke, G. and Marks, F. (1988) Carcinogenesis„ 9, 831–835PubMedCrossRefGoogle Scholar
  14. 14.
    Marks, F., Ganss, M. and Grimm, W. (1981) Biochem, Biophys. Acta, 678, 122–131Google Scholar
  15. 15.
    Marks, F. (1983) Carcinogenesis, 4, 1465–1470PubMedCrossRefGoogle Scholar
  16. 16.
    Marks, F., Clauss, M., Tiegel, A. and Richter, K. H. (1986) in Biological Regulation of Cell Proliferation (Baserga, R., Foa, P., Metcalf, D., Polli, E. E., eds.) pp. 267–274. Raven Press, New YorkGoogle Scholar
  17. 17.
    Yamaski, H. (1987) in Concept and Theories in Carcinogenesis (Maskens, A. P., Ebbesen, P., Burny, A., eds.) pp. 117–133. Excerpta Medica, Amsterdam etc.Google Scholar
  18. 18.
    Castagna, M., Takai, Y., Kaibuchi, K., Sano, K., Kikkawa, V. and Nishizuka, Y. (1982) J. Biol. Chem., 257, 7847–7851PubMedGoogle Scholar
  19. 19.
    Berridge, M. J. (1987) Biochim. Biophys. Acta, 907, 33–46PubMedGoogle Scholar
  20. 20.
    Ashendel, C. L. (1985) Biochim. Biophys. Acta, 822, 219–242PubMedGoogle Scholar
  21. 21.
    Marks, F., Furstenberger, G., Ganss, M., Richter, K. H. and Seemann, D. (1983) in Psoriasis: Cell Proliferation (Wright, N. A. and Camplejohn, R. S., eds.) pp. 173–188. Churchill Livingstone, Edinburgh etc.Google Scholar
  22. 22.
    Slaga, T. J., Scribner, J. D., Thompson, S. and Viaje, A. (1978) J. Natl. Cancer Inst., 52, 1611–1618Google Scholar
  23. 23.
    McCutcheon, J. A., Bickenback, J. C. and Mackenzie, J. C. (1985) J. Dental. Res., 64, 298Google Scholar
  24. 24.
    Klein-Szanto, A. J. P. (1984) in Mechanisms of Tumor Promotion (Slaga, T. J., ed.) Vol 2, pp. 41–72. CRC Press, Boca RatonGoogle Scholar
  25. 25.
    Marks, F., Bertsch, S., Grimm, W. and Schweizer, J. (1978) in Mechanisms of Tumor Promotion and Cocarcinogenesis (Slaga, T. J., Sivak, A., Boutwell, R. K., eds.) pp. 97–116. Raven Press, New YorkGoogle Scholar
  26. 26.
    Balmain, A. and Brown, K. (1988) Adv. Cancer Res., in pressGoogle Scholar
  27. 27.
    Hennings, H., Shores, R., Wenk, M. L., Spangler, E. F., -Tarone, R. and Yuspa, S. J. (1983) Nature, 304, 67–69PubMedCrossRefGoogle Scholar
  28. 28.
    Marks, F., Bertsch, S. and Furstenberger, G. (1979) Cancer Res., 38, 4183–4188Google Scholar
  29. 29.
    Furstenberger, G., Berry, D. D., Sorg, B. and Marks, F. (1981) Proc. Natl. Acad. Sci. USA, 78, 7722–7726PubMedCrossRefGoogle Scholar
  30. 30.
    Furstenberger, G., Kinzel, V., Schwarz, M. and Marks, F. (1985) Science 230, 76–78PubMedCrossRefGoogle Scholar
  31. 31.
    Yuspa, S. H. (1984) in Cellular Interactions by Environmental Tumor Promoters (Fujiki, H., Hecker, E., Moore, R. E., Sugimura, T., Weinstein I. B. eds.) pp. 315–326. Japan Scient. Soc. Press, Tokyo. VNU Science Press, UtrechtGoogle Scholar
  32. 32.
    Slags, T. J., Fischer, S. M., Nelson, K. and Gleasson, G. L. (1980) Proc. Natl. Acad. Sci. USA, 77, 3659–3663CrossRefGoogle Scholar
  33. 33.
    Sisskin, E. E., Gray, T. and Barrett, J. C. (1982) Carcinogenesis, 3, 403–408PubMedCrossRefGoogle Scholar
  34. 34.
    Kinzel, V., Furstenberger, G. and Marks, F. (1988) in Tumor Promoters: Biological Approaches for Mechanistic Studies and Assay Systems, in press Raven Press, New YorkGoogle Scholar
  35. 35.
    Furstenberger, G. and Marks, F. (1983) J. Invest. Dermatol., 81, 157s-161sPubMedCrossRefGoogle Scholar
  36. 36.
    Bauer, G., Hofler, P. and Simon, H. J. (1982) J. Biol. Chem., 257, 11405–11410, 11411–11415Google Scholar
  37. 37.
    Bauer, G., Hofler, P. and zur Hausen, H. (1982) Virology, 121, 184–194PubMedCrossRefGoogle Scholar
  38. 38.
    Rogers, M., Furstenberger, G., Marks, F., Bauer, G. and Hofler, P. (1988) in Hormones and Cancer (Proc. of the 3rd Int. Congress on Hormones and Cancer, Hamburg 1987), in press. Raven Press, New YorkGoogle Scholar
  39. 39.
    Kinzel, V., Loehrke, H., Goerttler, K., Furstenberger, G. and Marks, F. (1984) Proc. Natl. acad. Sci. USA, 81, 5858–5862PubMedCrossRefGoogle Scholar
  40. 40.
    Marks, F., Furstenberger, G., Gschwendt, M., Rogers, M., Schurich, B., Kaina, B. and Bauer, G. (1988) in Models and Mechanisms in Chemical Carcinogenesis (Feo, F. et al., eds.), in press. Plenum, New YorkGoogle Scholar
  41. 41.
    Coffey, R. J., Sipes, N. J., Bascom, C. C., Graves-Deal, R., Pennington, C. Y., Weissman, B. E. and Moses, H. L. (1988) Cancer Res., 48, 1596–1602.PubMedGoogle Scholar
  42. 42.
    Roberts, A. B., Thompson, N. L., Heine, U., Flanders, C. and Sporn, M. B. (1988) Brit. J. Cancer, 57, 594–600PubMedCrossRefGoogle Scholar
  43. 43.
    Gschwendt, M., Kittstein, W. and Marks, F. 91987) Carcinogenesis, 8, 203–207Google Scholar
  44. 44.
    Gschwendt, M., Kittstein, W. and Marks, F. (1987) Cancer Letters, 34, 187–191PubMedCrossRefGoogle Scholar
  45. 45.
    Coffey, R. J., Derynck, R., Wilcox, J. N., Bringman, T. S., Goustin, A. S., Moses, H. L. and Pttelkow, M. L. (1987) Nature, 328, 817–820PubMedCrossRefGoogle Scholar
  46. 46.
    Gottlieb, A. B., Chang, K. C., Posnett, D. N., Fanelli, G. and Tam, P. J. (1988) J. Exp. Med., 167, 670–675PubMedCrossRefGoogle Scholar
  47. 47.
    Akhurst, R. J., Fee, F. and Balmain, A. (1988) Nature, 331, 363–365PubMedCrossRefGoogle Scholar
  48. 48.
    Sporn, M. B., Roberts, A. B., Shull, J. H., Smith, J. M., Ward, J. M. and Sodek, J. 91983) Science, 219, 1329–1331Google Scholar
  49. 49.
    Schultz, G. S., White, M., Mitchell, R., Brown, G., Lynch, J., Twardzik, D. R. and Todaro, G. J. (1987) Science, 235, 350–352PubMedCrossRefGoogle Scholar
  50. 50.
    Schreiber, A. B., Winkler, M. and Derynck, R. (1986) Science, 232, 1250–1253PubMedCrossRefGoogle Scholar
  51. 51.
    Ristow, H. J. (1987) Proc. Natl. Acad. Sci. USA, 84, 1940–1944PubMedCrossRefGoogle Scholar
  52. 52.
    Luger, T. A., Kock, A., Danner, M., Colot, M. and Micksche, M. (1985) Brit, J. Dermatol., 113, Suppl. 28, 145–156CrossRefGoogle Scholar
  53. 53.
    Pittelkow, M. R. and Coffey, R. J. (1988) Ann. N. Y. Acad. Sci., in PressGoogle Scholar
  54. 54.
    Furstenberger, G., Gross, M., Schweizer, J., Vogt, I. and Marks, F. (1986) Carcinogenesis, 7, 1745–1753PubMedCrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1989

Authors and Affiliations

  • Friedrich Marks
    • 1
  • Gerhard Fürstenberger
    • 1
  1. 1.Institute of BiochemistryGerman Cancer Research CenterHeidelbergGermany

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