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Effect of S-Adenosyl-L-Methionine on Serum Lipoprotein in Experimental Hepatic Carcinogenesis

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Biochemistry of Chemical Carcinogenesis

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Summary

Plasma lipoprotein concentration and composition were investigated in experimental hepatic carcinogenesis induced by thioacetamide (TAA). The effect of S-adenosyl-L-methionine (SAM) on lipoprotein alterations during hepatic injury was also tested.

After 30 days administration of the weak carcinogen i.p. (50 mg/Kg/day) to male Wistar rates, a decrease of serum VLDL concentration and HDL accumulation in plasma was observed. Consequently, the HDL/VLDL ratio was elevated. Any increase of LDL/VLDL ratio was also observed. Total plasma phospholipids were lower than reference values. Sphingomyelin/phosphatidylethanolamine (SPH/PE) ratios/significantly decreased in plasma, as well as in VLDL-LDL and HDL fractions, as a consequence of the reduced SPH level and simultaneous increase of PE.

Treatment of experimental animals with SAM (2 mg/Kg/day) as well as with TAA for 30 days resulted in a normal level of serum VLDL and the HDL/VLDL ration. Phospholipid concentration in plasma was also normalized as a consequence of elevated level of these compounds in the VLDL-LDL fraction. Administration of SAM also prevented the decrease of SPH/PE ratio in plasma and different lipoproteins.

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Authors and Affiliations

  1. Instituto de Bioquimica. Facultad de Farmacia, Universidad Complutense, 28040, Madrid, Spain

    M. J. Miro, C. Arce, H. Aylagas, C. Fdez-Aguado & E. Palacious-Alaiz

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  1. M. J. Miro
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  2. C. Arce
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  3. H. Aylagas
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  4. C. Fdez-Aguado
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  5. E. Palacious-Alaiz
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Editors and Affiliations

  1. University of York, York, UK

    R. Colin Garner

  2. Research Institute for Tuberculosis and Respiratory Diseases, Prague, Czechoslovakia

    Jan Hradec

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© 1989 Plenum Press, New York

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Miro, M.J., Arce, C., Aylagas, H., Fdez-Aguado, C., Palacious-Alaiz, E. (1989). Effect of S-Adenosyl-L-Methionine on Serum Lipoprotein in Experimental Hepatic Carcinogenesis. In: Garner, R.C., Hradec, J. (eds) Biochemistry of Chemical Carcinogenesis. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-0539-2_30

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  • DOI: https://doi.org/10.1007/978-1-4613-0539-2_30

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4612-7856-6

  • Online ISBN: 978-1-4613-0539-2

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