Abstract
As the mechanisms of action of many chemopreventive substances are up to now poorly understood, it is difficult to classify them comprehensively. One of the categories of such chemicals which can prevent the formation of Nnitroso compounds from reactions of precursor amines and amides with nitrate is a topic of interest. As more and more data suggest that N-nitroso compounds may be cancer risks for man, the possibilities of the formation of Nnitroso compounds from nitrosatable drugs currently used in the GDR and the possibilities to inhibit or to reduce nitrosation by adding ascorbic acid have been investigated. The results obtained should encourage this special type of chemoprevention of cancer using ascorbic acid in combination with selected drugs.
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© 1989 Plenum Press, New York
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Schramm, T., Ziebarth, D. (1989). Cremoprevention and Reduction of Cancer Risks Caused by Nitrosatable Drugs. In: Garner, R.C., Hradec, J. (eds) Biochemistry of Chemical Carcinogenesis. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-0539-2_21
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DOI: https://doi.org/10.1007/978-1-4613-0539-2_21
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4612-7856-6
Online ISBN: 978-1-4613-0539-2
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