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Copper Complexes Stimulate Hemopoiesis and Lymphopoiesis

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Copper Bioavailability and Metabolism

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Abstract

Copper(II)2(3,5-diisopropylsalicylate)4[Cu(II)2(3, 5-DIPS)4] is a synthetic copper complex with a variety of effects, including radiation recovery, anti-inflammatory, and accelerated wound healing activities. When C57BL/6 mice were injected subcutaneously with 80 μmol/kg Cu (II) 2(3, 5-DIPS) 4their spleens significantly enlarged. This splenomegally lasted for at least 3 weeks and was accompanied by increased myelopoiesis in the spleen. Bone marrow had no significant change in cellularity or myelopoiesis. The treatment with Cu(II)2(3,5-DIPS)4had only minor effects on the ability of spleen cells to respond to mitogenic or antigenic stimulation. Cu(II)2(3,5-DIPS)4did stimulate lymphopoiesis, since it accelerated the recovery of immune reactivity following exposure to 8 Gy whole body irradiation. Copper levels in the spleens and bone marrow of unirradiated mice treated with Cu(II)2(3,5-DIPS)4were not significantly elevated 24 hr after treatment and copper levels were transiently reduced 7 days after treatment.

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Author information

Authors and Affiliations

  1. Department of Microbiology and Immunology, College of Medicine, Little Rock, AR, 72205, USA

    Lee S. F. Soderberg & John B. Barnett

  2. Department of Medicinal Chemistry, College of Pharmacy, University of Arkansas for Medical Sciences, Little Rock, AR, 72205, USA

    J. R. J. Sorenson

Authors
  1. Lee S. F. Soderberg
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  2. John B. Barnett
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  3. J. R. J. Sorenson
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Editor information

Editors and Affiliations

  1. Department of Human Nutrition and Food Service Management, University of Nebraska, Lincoln, Nebraska, USA

    Constance Kies

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© 1989 Plenum Press, New York

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Soderberg, L.S.F., Barnett, J.B., Sorenson, J.R.J. (1989). Copper Complexes Stimulate Hemopoiesis and Lymphopoiesis. In: Kies, C. (eds) Copper Bioavailability and Metabolism. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-0537-8_18

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  • DOI: https://doi.org/10.1007/978-1-4613-0537-8_18

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4612-7855-9

  • Online ISBN: 978-1-4613-0537-8

  • eBook Packages: Springer Book Archive

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