Copper Complexes Stimulate Hemopoiesis and Lymphopoiesis
Copper(II)2(3,5-diisopropylsalicylate)4[Cu(II)2(3, 5-DIPS)4] is a synthetic copper complex with a variety of effects, including radiation recovery, anti-inflammatory, and accelerated wound healing activities. When C57BL/6 mice were injected subcutaneously with 80 μmol/kg Cu (II) 2(3, 5-DIPS) 4their spleens significantly enlarged. This splenomegally lasted for at least 3 weeks and was accompanied by increased myelopoiesis in the spleen. Bone marrow had no significant change in cellularity or myelopoiesis. The treatment with Cu(II)2(3,5-DIPS)4had only minor effects on the ability of spleen cells to respond to mitogenic or antigenic stimulation. Cu(II)2(3,5-DIPS)4did stimulate lymphopoiesis, since it accelerated the recovery of immune reactivity following exposure to 8 Gy whole body irradiation. Copper levels in the spleens and bone marrow of unirradiated mice treated with Cu(II)2(3,5-DIPS)4were not significantly elevated 24 hr after treatment and copper levels were transiently reduced 7 days after treatment.
KeywordsSpleen Cell Copper Level Irradiate Mouse Spleen Weight Oxygen Radical Scavenger
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