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Copper Complexes Stimulate Hemopoiesis and Lymphopoiesis

  • Lee S. F. Soderberg
  • John B. Barnett
  • J. R. J. Sorenson

Abstract

Copper(II)2(3,5-diisopropylsalicylate)4[Cu(II)2(3, 5-DIPS)4] is a synthetic copper complex with a variety of effects, including radiation recovery, anti-inflammatory, and accelerated wound healing activities. When C57BL/6 mice were injected subcutaneously with 80 μmol/kg Cu (II) 2(3, 5-DIPS) 4their spleens significantly enlarged. This splenomegally lasted for at least 3 weeks and was accompanied by increased myelopoiesis in the spleen. Bone marrow had no significant change in cellularity or myelopoiesis. The treatment with Cu(II)2(3,5-DIPS)4had only minor effects on the ability of spleen cells to respond to mitogenic or antigenic stimulation. Cu(II)2(3,5-DIPS)4did stimulate lymphopoiesis, since it accelerated the recovery of immune reactivity following exposure to 8 Gy whole body irradiation. Copper levels in the spleens and bone marrow of unirradiated mice treated with Cu(II)2(3,5-DIPS)4were not significantly elevated 24 hr after treatment and copper levels were transiently reduced 7 days after treatment.

Keywords

Spleen Cell Copper Level Irradiate Mouse Spleen Weight Oxygen Radical Scavenger 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1989

Authors and Affiliations

  • Lee S. F. Soderberg
    • 1
  • John B. Barnett
    • 1
  • J. R. J. Sorenson
    • 2
  1. 1.Department of Microbiology and ImmunologyCollege of MedicineLittle RockUSA
  2. 2.Department of Medicinal ChemistryCollege of Pharmacy, University of Arkansas for Medical SciencesLittle RockUSA

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