Abstract
The relationship of copper and zinc intake with serum total cholesterol, and HDL-cholesterol was studied in physically active and sedentary elderly men and women (N=63). Three-day diet records over a period of twelve months and fasting blood samples were collected from each subject. Physical activity was associated with higher copper and zinc intakes, lower serum total cholesterol and higher serum copper levels. Higher copper intakes were associated with lower serum total cholesterol. Higher zinc intakes were associated with lower HDL-cholesterol levels. Higher copper serum levels were associated with lower serum total cholesterol. These results appeared inconsistent with the reports from animal studies. However, with it should be noted that the subjects in this study had copper and zinc intakes below the recommended dietary allowances and the calculated zinc to copper ratios were within the desired ranges.
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Literature Cited
Aumodt, R.L.; Rumble, W.F.; Johnston, G.J.; Markley, E.J.; Henkin, R.J.; Human Zinc Absorption is age dependent. Fed. Proc. 1981; 40:940 (abstr.).
Allen, K.G.D.; Klevay, L.M., Cholesterol Metabolism in Copper Deficient Rats. Li. Sci. 1978; 22:1691.
Allain, C.C; Poon, L.S.; Chon, C.S.G.; Richmond, W.; Fu, P.C. Enzymatic Determination of total Serum Cholesterol. Clin Chem. 1974; 20:470.
Bunker, V. W.; Hinks, L.J.; Stansfield, F.M.; Lawson, J.S.; Clayton, B.E. Metabolic balance Studies for Zinc and Copper in housebound elderly people and the relationship between zinc balance and leukocyte zinc concentrations. 1987; AM J Clin Nutr.; 46:353.
Burke, D.M.; DeMicco, F.J.; Taps, L.J.; Ritchey, S.J., Copper and Zinc Utilization in elderly adults. J. Gerontol 1981; 36:558.
Food and Nutrition Board. Recommended dietary allowances. 9th ed., Washington D.C, National Academy of Sciences, 1980.
Fletcher, M.J., A Colorimetric Method for estimating serum triglycerides. Clin. Chem. ADA 1968; 22:393.
Garry, P.J.; Goodwin, J.S.; Hunt, W.C; Hoops, E.M.; Leonard, A.G., Nutritional Status in a healthy elderly population: dietary and supplemental intakes. AM J. Clin Nutr 1982; 36:319.
Gibson, R.S.; Martinex, O.B.; MacDonald, A.C., The zinc, copper and selenium status of a selected Sample of Canadian elderly women. J. Gerontol. 1985; 40:296.
Halstead, J.A.; Smith, Jr. J.C, Plasma zinc in health and disease, Lancet 1970; 1:322.
Holden, J.M., Wolf, W.R., Mertz, W., Zinc and Copper in self-selected diets. J. Am Diet. Assoc. 1979; 75:23.
Klevay, L.M., Coronary heart disease: The zinc/copper hypothesis. Am. J. Clin. Nutr. 1975; 28:764.
Klevay, L.M.; Imman, L.; Johnson, L.K.; Lawler, M.; Mahalko, J.R.; Milne, D.B., LuKaski, H.C; Bolonchuk, W.; Sanslead, H.H., Increased Cholesterol in plasma in a young man during experimental copper depletion. Metabolism 1984; 33:112.
Krebs, J.M.; Schneider, U.S.; LeBlanc, A.D., Zinc, Copper and Nitrogen balances during bed rest and fluoride supplementation in healthy adult males. Am J. Clin. Nutr. 1988; 47:509.
Koo, S.I.; Williams D.A., Relationship between nutritional status of zinc and cholesteral concentration of serum lipproteins in adult male rats. Am J. Clin. Nutr. 1981; 34:2376.
Koo, S.I.; Lee, C.C, Compositional changes in plasma high-density lipoprotein particles in marginally zinc-deficient male rats. Am J. Clin Nutr. 1988; 47:120.
Lefevre, M.; Keen, C.L.; Lonnerdal, B.; Hurley, L.S.; Schneeman, B.O., Copper deficiency induced hypercholesterolemia: Effects on HDL subtractions and hepatic lipoprotein receptor subfractions and hepatic lipoprotein receptor activity in the rat. J. Nutr. 1986; 116:1735.
Koo, S.I.; Lee, C.C, Compositional changes in plasma high-density lipoprotein particles in marginally zinc-deficient male rats. Am J. Clin Nutr. 1988; 47:120.
McGrandy, R.B.; Russell, R.M.; Hrtz, S.C; Jacob, K.A.; Tannenbaum, S.; Peters, H.; Sahyoun, N.; Otradovec, C.L., Nutritional status survey of healthy non-institutionalized elderly: energy and nutrient intakes from three-day diet records and nutrient Supplements. Nutr. Res. 6:785–798; 1986.
Medeiros, D.; Pellum, L.; Brown, B. Serum lipids and glucose as associated with hemoglobin levels and copper and zinc intake in young adults. Life Sci. 1983; 32:1897.
Mertz, W., Trace minerals and arteriosclerosis, Fed. Proc. 1982; 41:2807.
Netsky, M.G., Harrison, W.W.; Brown, M.; Benson, C., Tissue zinc and human disease, Relation of zinc content of kidney, liver and lung to arteriosclerosis and hypertension, Am. J. Clin. Pathol. 1969; 51:358.
Parker, M.M.; Humoller, F.L.; Mahler, D.J., Determination of copper and zinc in biological material. Clin. Chem. 1967; 13:40.
Ravin, H.A., An improved colorimetric enzymatic assay of ceruloplasmin, J. Lab. Clin. Med. 1961; 58:161.
Snedicor, G.W.; Cochran, W.G., Statistical Methods, 7th ed. Ames Ia: Iowa State University Press, 1980.
Turnlund, J.; Costa, F.; Margen, S., Zinc, copper and iron balance in elderly men, Am. J. Clin. Nutr. 1981; 34:2641.
Turnlund, J.R.; Michel, M.C; Keyes, W.R.; Schutz, Y; Marten, S., Copper absorption in elderly men determined by using stable 65CU. Am. J. Clin. Nutr. 1982; 36:587.
Turnlund, J.R.; Durkin, N.; Morgen, S., Zinc absorption in young and elderly men. Fed. Proc. 1984; 43:850 (abstr.).
Williams, M.H., Nutritional Aspects of human physical and athletic performance. 2nd ed. Charles C Thomas Pub., Springfield, I11, 1985.
Yearick, E.S.; Wang, M.L.; PisiasS.J. Nutritional Status of the elderly: Dietary and biochemical findings, J. Gerontol. 35:663–667; 1980.
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© 1989 Plenum Press, New York
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Umoren, J. (1989). Serum Total Cholesterol and HDL-Cholesterol Levels as Associated with Copper and Zinc Intake in Physically Active and Sedentary Elderly Men and Women. In: Kies, C. (eds) Copper Bioavailability and Metabolism. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-0537-8_15
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DOI: https://doi.org/10.1007/978-1-4613-0537-8_15
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