Summary
Previous results regarding the two metalloforms of MT which accumulate in chick liver following the parenteral administration (ip) of copper were discussed. One metalloform, which is exclusively zinc, was suggested to reflect the marked accumulation of hepatic zinc following copper injection. The present report shows that there is a marked difference in hepatic zinc accumulation if copper is administered iv. Under these conditions there is virtually no change in hepatic zinc and thus MT produced under these conditions appears to contain only copper. We suggest the the changes in zinc metabolism as effected by copper when given intraperitoneally reflect a secondary response analogous to that observed when iron is similarly administered.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Bremner, I., Mehra, R.K., Morrison, J.N, Wood, A.M (1986) Effects of dietary copper supplementation of rats on the occurrence of metallothionein-1 in liver and its secretion into blood, bile and urine. Biochem. J. 235:735.
Durnam, D.M, Palmiter, R.D. (1981) Transcriptional regulation of the mouse metallothionein-1 gene by heavy metals. J. Biol. Chem. 256:5712.
Geller, B.L., Winge, D.R. (1982) Metal binding sites of rat liver Cu-thionein. Arch. Biochem. Biophys. 213:109.
Hamer, D.H. (1986) Metallothionein. Ann. Rev. Biochem. 55:913.
Kagi, J.H.R., Schaffer, A. (1988) Biochemistry of Metallothionein. Biochem. 27:8509.
Mehra, R.K., Bremner, I. (1984) Species differences in the occurrence of copper-metallothionein in the particulate fractions of the liver copper-loaded animals. Biochem. J. 219:539.
McCormick, C.C. (1984) Tissue specific accumulation of hepatic zinc metallothionein following parenteral iron loading. Proc. Soc. Exp. Biol. Med. 176:392.
McCormick, C.C. (1987) Iron-induced accumulation of hepatic metallothionein: The lack of glucocorticoid involvement. Proc. Soc. Exp. Biol. Med. 185:143.
McCormick, C.C. (1986) Iron-induced accumulation of hepatic zinc metallothionein: A marked diminution by short-term dietary zinc depletion. Fed. Proc. 45:1085.
McCormick, C.C., Lin, L-Y. (1988) The occurrence of Zn7 and Zn, Cu metallothionein in liver of copper-loaded chicks. Proc. 6th International Symposium on Trace Element Metabolism in Man and Animals. ‘In Press’.
McCormick, C.C, Fullmer, C.S., Garvey, J.S. (1988a) Amino acid sequence and comparative antigenicity of chick metallothionein. Proc. Natl. Acad. Sci. (USA) 85:309.
McCormick, CC, Golemboski, K.A., Fleet, J.C, Dietert, R.R. (1988b) Parenteral iron and hepatic metallothionein induction: Characteristics of an associated inflammatory response. FASEB J. 2:A865.
Wake, S.A., Mercer, J.F. (1985) Induction of metallothionein mRNA in rat liver and kidney after copper chloride injection. Biochem. J. 228:425.
Wei, D. Andrews, G.K. (1988) Molecular cloning of chicken metallothionein. Deduction of the complete amino acid sequence and analysis of expression using cloned cDNA. Nucleic Acid Res. 16:537.
Winge, D.R., Geller, B.L., Garvey, J. (1981) Isolation of copper thionein from rat liver. Arch. Biochem. Biophys. 208:160.
Winge, D.R., Premakumar, R., Wiley, R.D., Rajogopalan, K.V. (1975) Copper-chelatin: Purification and properties of a copper binding protein from rat liver. Arch. Biochem. Biophys. 170:253.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1989 Plenum Press, New York
About this chapter
Cite this chapter
McCormick, C.C., Lin, LY., Fleet, J.C. (1989). Metalloforms of Metallothionein Induced by Parenteral Copper: The Influence of Route of Administration. In: Kies, C. (eds) Copper Bioavailability and Metabolism. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-0537-8_10
Download citation
DOI: https://doi.org/10.1007/978-1-4613-0537-8_10
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4612-7855-9
Online ISBN: 978-1-4613-0537-8
eBook Packages: Springer Book Archive