Supraspinal Descending Control of Propriospinal Respiratory Neurons in the Cat

  • Mamoru Aoki
  • Yutaka Fujito
  • Isao Kosaka
  • Nobuyoshi Kobayashi


Previous studies by us2–5,7,8 and others9,15 demonstrated that the cervical respiratory neurons are localized in upper cervical segments C1 to C3, near the border of the intermediate gray matter in cats, rats and monkeys. These neurons, which are mostly inspiratory in cats, receive descending inputs from the brainstem, have axons which descend in the cord ipsilaterally and arborize in the lower cervical, thoracic and lumbar segments11,17,19.


Sensorimotor Cortex Cerebral Peduncle Respiratory Neuron Phrenic Nerve Activity Propriospinal Neuron 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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  1. 1.
    B. Alstermark, A. Lundberg, U. Norrsell, and E. Sybirska, Integration in descending motor pathways controlling the forelimb in the cat. Exp. Brain Res., 42:299–318 (1981).PubMedCrossRefGoogle Scholar
  2. 2.
    M. Aoki, S. Mori, K. Kawahara, H. Watanabe, and N. Ebata, Generation of spontaneous respiratory rhythm in high spinal cats. Brain Res., 202:51–63 (1980).PubMedGoogle Scholar
  3. 3.
    M. Aoki, Respiratory-related neuron activities in the cervical cord of the cat. in: Proceedings of the International Symposium. “Central Neural Production of Periodic Respiratory Movements”, J. L. Feldman, A. J. Berger, eds., Northwestern Univ., Chicago, pp 155–156 (1982).Google Scholar
  4. 4.
    M. Aoki, T. Kasaba, and Y. Kurosawa, Properties of respiratory neurons in the upper cervical cord of the cat. Neurosci. Lett. Suppl., 13:S9 (1983).Google Scholar
  5. 5.
    M. Aoki, T. Kasaba, Y. Kurosawa, K. Ohtsuka, and H. Satomi, The projection of cervical respiratory neurons to the phrenic nucleus in the cat. Neurosci. Lett. Suppl., 17:S49 (1984).Google Scholar
  6. 6.
    M. Aoki, Y. Fujito, Y. Kurosawa, H. Kawamura, and H. Kawasaki, Brainstem control of the respiratory spinal relay center. Neurosci. Res. Suppl., 3:S78 (1986).CrossRefGoogle Scholar
  7. 7.
    M. Aoki, Y. Fujito, Y. Kurosawa, H. Kawasaki, and I. Kosaka, Descending inputs to the upper cervical inspiratory neurons from the medullary respiratory neurons and the raphe nuclei in the cat. in: “Respiratory Muscles and Their Neuromotor Control,” G. C. Sieck, S. C. Gandevia, W. E. Cameron, eds., A. R. Liss, New York, pp 75–82 (1987).Google Scholar
  8. 8.
    M. Aoki, I. Kosaka, and Y. Fujito, Effects of stimulation of cerebrofugal fibers on the spinal respiratory neuron activities in the cat. J. Physiol. Soc. Jap., 50:593 (1988).Google Scholar
  9. 9.
    J. Duffin and R. W. Hoskin, Intracellular recordings from upper cervical inspiratory neurons in the cat. Brain Res., 435:351–354 (1987).PubMedCrossRefGoogle Scholar
  10. 10.
    C. von Euler and T. Trippenbach, Excitability changes of the inspiratory ‘off-switch’ mechanism tested by electrical stimulation in nucleus parabrachialis in the cat. Acta Physiol. Scand., 97:175–188 (1976).CrossRefGoogle Scholar
  11. 11.
    C. von Euler, Brain stem mechanisms for generation and control of breathing pattern, in: “Handbook of Physiology: The Respiratory System, Section 3, vol. II,” A. P. Fishman, N. S. Cherniac, J. G. Widdicombe, eds., American Physiological Society, Bethesda, pp 1–67 (1986).Google Scholar
  12. 12.
    Y. Fujito, N. Kobayashi, and M. Aoki, Electrophysiological and histological investigation of cerebrofugal inputs to the medullary and spinal respiratory neurons in the cat, J. Physiol. Soc. Jap. 50:593 (1988).Google Scholar
  13. 13.
    C. R. Gerfen and P. E. Sawchenko, An anterograde neuroanatomical tracing method that shows the detailed morphology of neurons, their axons and terminals: immunohistochemical localization of an axonally transported plant lectin, Phaseolus vulgaris leucoagglutinin (PHA-L). Brain Res., 290:219–238 (1984).PubMedCrossRefGoogle Scholar
  14. 14.
    J. R. Jr. Holtman, W. P. Norman, and R. A. Gillis, Projection from the raphe nuclei to the phrenic motor nucleus in the cat. Neurosci. Lett., 44:105–111 (1984).PubMedCrossRefGoogle Scholar
  15. 15.
    J. Lipski and J. Duffin, An electrophysiological investigation of ropriospinal inspiratory neurons in the upper cervical cord of the cat. Exp. Brain Res., 61:625–637 (1986).PubMedGoogle Scholar
  16. 16.
    J. Lipski, A. Bektas, and R. Porter, Short latency inputs to phrenic motoneurons from the sensorimotor cortex in the cat. Exp. Brain Res., 61:280–290 (1986).PubMedGoogle Scholar
  17. 17.
    A. D. Miller, K. Ezure, and I. Suzuki, Control of abdominal muscles by brain stem respiratory neurons in the cat. J. Neurophysiol., 54:155–167 (1985).PubMedGoogle Scholar
  18. 18.
    G. C. Rikard-Bell, E. K. Bystrzycka, and B. S. Nail, Cells of origin of corticospinal projections to phrenic and thoracic respiratory motoneurons in the cat as shown by retrograde transport of HRP. Brain Res. Bull., 14:39–47 (1985).PubMedCrossRefGoogle Scholar
  19. 19.
    S.-I. Sasaki, M. Edamura, K. Yokogushi, and M. Aoki, Distribution pattern of collateral branches of upper cervical neurons in the cat lower spinal cord. J. Physiol. Soc. Jap., 50:593 (1988).Google Scholar

Copyright information

© Plenum Press, New York 1989

Authors and Affiliations

  • Mamoru Aoki
    • 1
  • Yutaka Fujito
    • 1
  • Isao Kosaka
    • 1
  • Nobuyoshi Kobayashi
    • 1
  1. 1.Department of PhysiologySapporo Medical CollegeSapporo 060Japan

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