Ventilatory Responses to Short Carotid Sinus Pressure Stimuli: Interpretation Using a Model of Rhythm Generation
Understanding how the respiratory system responds to complex stimuli, such as exercise, requires an understanding of the integrative control of the cardiovascular and respiratory systems. This paper deals with one aspect of the control of such systems, namely, the reflex inhibition of ventilation upon stimulating the carotid sinus baroreceptors. Although the existence of a reflex from baroreceptors to ventilation was described by Heymans and Neil (5), this reflex has received relatively little attention until quite recently (3,4). The goal of this paper is to describe the dependence of the ventilatory responses on the timing of brief intracarotid pressure stimuli within a respiratory cycle, and to interpret the results in terms of the model of respiratory rhythm generation proposed by Richter et al.(9) using the mathematical description of Botros (2).
KeywordsVentilatory Response Carotid Sinus Neuron Pool Pressure Stimulus Phrenic Nerve Activity
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- 1.S.M. Botros and E.N. Bruce. A new mathematical model for the respiratory rhythm generator. Proc. of the 9th Annual IEEE-EMBS Conference, Boston, 2058–2059 (1987).Google Scholar
- 2.S.M. Botros. A mathematical model for the respiratory central pattern generator. M.S. Thesis, Department of Biomedical Engineering, Case Western Reserve University. Cleveland, OH (1988)Google Scholar
- 4.E.L. Dove and P.G. Katona. Respiratory effects of brief baroreceptor stimuli in the anesthetized dog. J. Appl. Physiol. 59:1259–1265 (1985).Google Scholar
- 5.C. Heymans and E. Neil. Reflexogenic Areas of the Cardiovascular System. J. & A. Churchill Ltd, London (1958).Google Scholar
- 6.R. Maass-Moreno. Species differences in the respiratory responses to short baroreceptor stimuli in the dog and the cat. Ph.D. Thesis. Department of Biomedial Engineering, Case Western Reserve University, Cleveland, OH (1988)Google Scholar
- 7.R. Maass Moreno and P.G. Katona. The baroventilatory reflex in the dog and the cat: species differences in ventilatory responses to short carotid sinus pressure stimuli. Pf lugers Arch. Suppl.1, 411:R54 (1988).Google Scholar
- 9.D. Richter, D. Ballantyne, and J.E. Remmers. How is the respiratory rhythm generated? NIPS 1:109–112 (1936).Google Scholar