Evidence in Man to Suggest Interaction Between the Peripheral and Central Chemoreceptors
The interaction between the ventilatory stimuli of hypoxia and carbon dioxide has been recognised for some considerable time1,2. A similar interaction between the two stimuli has been observed in their effects on the discharge of the carotid sinus nerve of the anaesthetised cat3,4. In man, the withdrawal of a hypercapnic stimulus in hyperoxia has a longer latency than the withdrawal of the hypercapnic stimulus in hypoxia5. This suggests that hyperoxia abolishes the effect of hypercapnia at the carotid body, and thus is supportive of the notion that hypoxia and hypercapnia interact at the level of the carotid body in man.
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