Advertisement

Evidence in Man to Suggest Interaction Between the Peripheral and Central Chemoreceptors

  • P. A. Robbins

Abstract

The interaction between the ventilatory stimuli of hypoxia and carbon dioxide has been recognised for some considerable time1,2. A similar interaction between the two stimuli has been observed in their effects on the discharge of the carotid sinus nerve of the anaesthetised cat3,4. In man, the withdrawal of a hypercapnic stimulus in hyperoxia has a longer latency than the withdrawal of the hypercapnic stimulus in hypoxia5. This suggests that hyperoxia abolishes the effect of hypercapnia at the carotid body, and thus is supportive of the notion that hypoxia and hypercapnia interact at the level of the carotid body in man.

Keywords

Carotid Body Ventilatory Response Respiratory Volume Peripheral Chemoreceptor Carotid Sinus Nerve 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    M. Nielsen and H. Smith, Studies on the regulation of respiration in acute hypoxia, Acta physiol. scand., 24:293 (1952).PubMedCrossRefGoogle Scholar
  2. 2.
    B.B. Lloyd, M.G.M. Jukes and D.J.C. Cunningham, The relation between alveolar oxygen pressure and the respiratory response to carbon dioxide in man, Quart. J. Exp. Physiol., 43:214 (1958).PubMedGoogle Scholar
  3. 3.
    T.F. Hornbein, Z.J. Griffo and A. Roos, Quantitation of chemoreceptor activity: interrelation of hypoxia and hypercapnia, J. Neurophysool., 24:561 (1961).Google Scholar
  4. 4.
    S. Lahiri and R.G. Delaney, Stimulus interaction in the responses of carotid body chemoreceptor single afferent fibres, Respir. Physiol., 24:249 (1975).PubMedCrossRefGoogle Scholar
  5. 5.
    J.P. Miller, D.J.C. Cunningham, B.B. Lloyd and J.M. Young, The transient respiratory effects in man of sudden changes in alveolar CO2 in hypoxia and in high oxygen, Respir. Physiol. 20:17 (1974).PubMedCrossRefGoogle Scholar
  6. 6.
    J.H.G.M. van Beek, A. Berkenbosch, J. de Goede and C.N. Olievier, Influence of peripheral O2 tension on the ventilatory response to CO2 in cats. Respir. Physiol., 51:379 (1983).PubMedCrossRefGoogle Scholar
  7. 7.
    P.A. Robbins, Evidence for interaction between the contributions to ventilation from the central and peripheral chemoreceptors in man, J. Physiol., 401:503 (1988).PubMedGoogle Scholar
  8. 8.
    M.G. Howson, S. Khamnei, M.E. McIntyre, D.F. O’Connor and P.A. Robbins, The properties of a turbine device for measuring respiratory volumes in man, J. Physiol., 382:12P (1986).Google Scholar
  9. 9.
    M.G. Howson, S. Khamnei, M.E. McIntyre, D.F. O’Connor and P.A. Robbins, A rapid computer-controlled binary gas-mixing system for studies in respiratory control, J. Physiol., 394:7P (1987).Google Scholar
  10. 10.
    W.S. Yamamoto, Transmission of information by the arterial blood stream with particular reference to carbon dioxide, Biophvs. J., 2:143 (1962).CrossRefGoogle Scholar
  11. 11.
    D.J.C. Cunningham, P.A. Robbins and C.B. Wolff, Integration of respiratory responses to changes in alveolar partial pressures of CO2 and O2 and in arterial pH, in: “Handbook of Physiology: The Respiratory System”, vol 2, N.S. Cherniack and J.G. Widdicombe, ed., American Physiological Society, Bethesda (1986).Google Scholar
  12. 12.
    N.H. Edelman, P.E. Epstein, S. Lahiri and N.S. Cherniack, Ventilatory responses to transient hypoxia and hypercapnia in man, Respir. Physiol., 17:302 (1973).PubMedCrossRefGoogle Scholar
  13. 13.
    J.W. Bellville, B.J. Whipp, R.D. Kaufman, G.D. Swanson, K.A. Aqleh and D.M. Wiberg, Central and peripheral chemoreflex loop gain in normal and carotid body-resected subjects, J. Appl. Physiol. 46:843 (1979).PubMedGoogle Scholar

Copyright information

© Plenum Press, New York 1989

Authors and Affiliations

  • P. A. Robbins
    • 1
  1. 1.University Laboratory of PhysiologyOxfordUK

Personalised recommendations