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Hypoxia >25 Years After Carotid Body Resection Causes More Tachycardia Although Less Hyperventilation than in Controls

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Respiratory Control

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Abstract

Enhanced hypoxic tachycardia during breath holding in the patients with carotid-body resection was already found by Gross et al.1. However, from the same institute Lugliani et al.2 reported no significant difference in heart rate (HR) during spontaneous hypoxic respiration between such patients and the control subjects, although no quantitative data were presented. Furthermore, disagreement of the role of the carotid bodies on HR are seen among conscious and anesthetized animals reported by number of investigators.

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References

  1. D. M. Gross, B.J. Whipp, J. T. Davidson, S. N. Koyal and K. Wasserman, Role of the carotid bodies in the heart rate response to breath holding in man. J. Appl. Physiol. 41: 336–340 (1966).

    Google Scholar 

  2. R. Lugliani, B. J. Whipp and K. Wasserman A role for the carotid body in cardiovascular control in man. Chest 63: 744–750 (1973).

    Article  PubMed  CAS  Google Scholar 

  3. Y. Honda, S. Watanabe, I. Hashizume, Y. Satomura, N. Hata, Y. Sakakibara and J. W. Severinghaus Hypoxic chemosensitivity in asthmatic patients two decades after carotid body resection. J. Appl. Physiol. 46: 632–638 (1979).

    PubMed  CAS  Google Scholar 

  4. R. Kronenberg, F. N. Hamilton, R. Gabel, R. D. Hickey, D. J. C. Read and J. W. Severinghaus Comparison of three methods for quantitating respiratory response to hypoxia in man. Respir. Physiol. 16: 109–125 (1972).

    Article  PubMed  CAS  Google Scholar 

  5. M. De B. Daly Reflex circulatory and respiratory responses to hypoxia In: Oxygen in the animal organism, Dickens, F. and Neil, E. ed., pp. 267–276, Oxford, Pergamon Press (1964)

    Google Scholar 

  6. J. C. G. Coleridge and H. M. Coleridge Chemoreflex regulation of the heart. In: Handbook of Physiology, Sec. 2, The Cardiovascular system, The Heart, Vol. 1, Berne, R. M., Sperelakis, N. and Geiger, S.T. ed., pp. 653–676, Bethesda, Am. Physiol. Soc. (1979)

    Google Scholar 

  7. A. Trzebski, J. Lipski, S. Majchercyzk, P. Szulezyk and L. Chruscielski, Central organization and interaction of the carotid baroreceptor and chemoreceptor sympathetic reflex. Brain Res. 67: 227–237 (1975)

    Article  Google Scholar 

  8. M. Kollai and K. Koizumi Reciprocal and non-reciptocal action of the vagal and sympathetic nerves innervating the heart. J. Aut. Nerv. System. 1: 33–52 (1979)

    Article  CAS  Google Scholar 

  9. D. Davidson, S. A. Stalcap and R. B. Melins Systemic hemodynamics affecting cardiac output during hypocapnic and hypercapnic hypoxia. J. Appl. Physiol. 60: 1230–1236 (1986)

    PubMed  CAS  Google Scholar 

  10. M. DeB. Daly and M. J. Scott The effect of hypoxia on the heart rate of the dog with special reference to the contribution of the carotid body chemoreceptors. J. Physiol. 145: 440–446 (1959)

    Google Scholar 

  11. J. E. Angel-James and M. Meb. Daly Cardiovascular responses in apneic asphyxia: role of arterial chemoreceptors and the modification of their effects by a pulmonary vagal inflation reflex. J. Physiol. 201: 87–104 (1969)

    Google Scholar 

  12. D. B. Katzin and E. H. Rubinstein Vagal control of heart rate during hypoxia in the cat. Proc. Soc. Exp. Biol. Med. 147: 551–557 (1974)

    PubMed  CAS  Google Scholar 

  13. R. C. Koehler, B. W. McDonald and J. A. Krasney Influence of CO2 on cardiovascular response to hypoxia in conscious dogs. Am. J. Physiol. 239: H548–H558 (1980)

    Google Scholar 

  14. J. A. Krasney, M. G. Magno, M. G. Levitzky, R. C. Koehler and D. G. Davis Cardiovascular responses to arterial hypoxia in awake sino-aortic-denervated dogs. J. Appl. Physiol. 35: 733–738 (1973)

    PubMed  CAS  Google Scholar 

  15. J. Litwin and K. Skolasińska On the mechanism for bradycardia induced by acute systemic anoxia in the dog. Pflüg. Arch. 289: 109–121 (1966)

    Article  CAS  Google Scholar 

  16. P. I. Korner, J. B. Uther and S. W. White Central nervous integration of the circulatory responses to arterial hypoxemia in the rabbit. Cir. Res. 24: 757–776 (1969)

    CAS  Google Scholar 

  17. S. Stern and E. Rapaport Comparison of the reflexes elicited from combined or separate stimulation of the aortic and carotid chemoreceptors on myocardial contractility, cardiac output and systemic resistance. Cir. Res. 87: 227–237 (1967)

    Google Scholar 

  18. E. Neil Influence of the carotid chemoreceptor reflexes on the heart rate in systemic anoxia. Arch. Intern. Pharmacodyn. Therap. 105: 477–488 (1956)

    CAS  Google Scholar 

  19. H. R. Kirchheim Systemic arterial baroreceptor reflexes. Physiol. Rev. 56: 100–176 (1976)

    PubMed  CAS  Google Scholar 

  20. J. D. Bristow, E. B. Brown Jr., K. J. C. Cunningham, M. G. Howson, M. J. R. Lee, T. G. Pickering and P. Sleight The effect of raising alveolar Pco2 and ventilation separately and together on the sensitivity and setting of the baroreceptor cardiaodepressor reflex in man. J. Physiol. 243: 401–425 (1974)

    PubMed  CAS  Google Scholar 

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Author information

Authors and Affiliations

  1. Department of Physiology and Chest Medicine, School of Medicine, Chiba University, Chiba, Japan

    Yoshiyuki Honda, Ikko Hashizume, Hiroshi Kimura & John Severinghaus

  2. Department of Anesthesia and CVRI, University of California, San Francisco, USA

    Yoshiyuki Honda, Ikko Hashizume, Hiroshi Kimura & John Severinghaus

Authors
  1. Yoshiyuki Honda
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  2. Ikko Hashizume
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  3. Hiroshi Kimura
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  4. John Severinghaus
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Editor information

Editors and Affiliations

  1. University of Colorado Health Science Center, Denver, Colorado, USA

    George D. Swanson

  2. California State University, Chico, Chico, California, USA

    George D. Swanson

  3. Late of University of Southern California, Los Angeles, California, USA

    Fred S. Grodins

  4. University of Waterloo, Waterloo, Ontario, Canada

    Richard L. Hughson

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© 1989 Plenum Press, New York

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Honda, Y., Hashizume, I., Kimura, H., Severinghaus, J. (1989). Hypoxia >25 Years After Carotid Body Resection Causes More Tachycardia Although Less Hyperventilation than in Controls. In: Swanson, G.D., Grodins, F.S., Hughson, R.L. (eds) Respiratory Control. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-0529-3_22

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  • DOI: https://doi.org/10.1007/978-1-4613-0529-3_22

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4612-7851-1

  • Online ISBN: 978-1-4613-0529-3

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