Increased Arterial Potassium Levels May Contribute to the Drive to Breathe at Very High Altitude

  • David J. Paterson
  • Piers C. G. Nye


This work reports observations on the excitation of arterial chemoreceptors by potassium and how this excitation is affected by hypoxia and hypercapnia. It is, partly for topical reasons, wrapped in the story of Mabel Fitzgerald’s visit to Colorado in 1911.


Ventilatory Response Plasma Potassium Rectangular Hyperbola Carotid Sinus Nerve Vertical Asymptote 
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  1. 1.
    M.P. Fitzgerald, Further observations on the changes in the breathing and the blood at various high altitudes. Proc. Roy. Soc. 88:248 (1914).CrossRefGoogle Scholar
  2. 2.
    J.B. West, P.H. Hackett, K.H. Maret, J.S. Milledge, R.M. Peters, C.J. Pizzo, and R.M. Winslow, Pulmonary gas exchange on the summit of Mount Everest. J. appl. Physiol. 55:678 (1983).PubMedGoogle Scholar
  3. 3.
    R.A.F. Linton, M. Lim, and D.M. Band, Continuous intravascular monitoring of plasma potassium using ion-selective electrode catheters. Critical Care Medicine. 10:337 (1982).PubMedCrossRefGoogle Scholar
  4. 4.
    D.J. Paterson, J.A. Estavillo, and P.C.G. Nye, The effect of hypoxia on plasma potassium concentration and the excitation of arterial chemoreceptors in the cat. O. J. exp. Physiol. 73:623 (1988).Google Scholar
  5. 5.
    D.J. Paterson, P.A. Robbins, J. Conway, and P.C.G. Nye, Does arterial plasma potassium contribute to exercise hyperpnoea? This volume. Google Scholar
  6. 6.
    D.M. Band, R.A.F. Linton, R. Kent, and F.L. Kurer, The effect of peripheral chemodenervation on the ventilatory response to potassium. Respir. Physiol.. 60:217 (1985).PubMedCrossRefGoogle Scholar
  7. 7.
    R.E. Burger, J.A. Estavillo, P. Kumar, P.C.G. Nye, and D.J. Paterson, Effects of potassium, oxygen and carbon dioxide on the steady-state discharge of cat carotid body chemoreceptors. J. Physiol. (London). 401:519 (1988).Google Scholar

Copyright information

© Plenum Press, New York 1989

Authors and Affiliations

  • David J. Paterson
    • 1
  • Piers C. G. Nye
    • 1
  1. 1.University Laboratory of PhysiologyOxfordEngland

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