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Nonketotic Hyperglycinemia

A Paradigm for the Application of Neuroscience to the Understanding and Treatment of a Developmental Disorder

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Application of Basic Neuroscience to Child Psychiatry

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Abstract

Nonketotic hyperglycinemia is an autosomal-recessive disorder that usually presents during the neonatal period and, in its classic or typical form, is characterized by poor muscle tone, feeding difficulties, intractable seizures, and death due to respiratory insufficiency.1,2 Phenotypically, the disorder can be quite heterogeneous; atypical presentations include mild mental retardation and expressive language difficulties as the sole features.3-8 In many ways, nonketotic hyperglycinemia serves as a paradigm for the application of basic neuroscience to the understanding and treatment of a developmental disorder.

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Author information

Authors and Affiliations

  1. Psychiatry Service, Veterans Administration Medical Center, and Department of Psychiatry, Georgetown University School of Medicine, Washington, D.C., 20007, USA

    Stephen I. Deutsch & Lynn H. Deutsch

  2. Pediatric Department, Hasharon Hospital, Petah Tiqva, 49372, Israel

    Ronit Weizman

  3. Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, 69978, Israel

    Ronit Weizman

Authors
  1. Stephen I. Deutsch
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  2. Lynn H. Deutsch
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  3. Ronit Weizman
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Editor information

Editors and Affiliations

  1. Veterans Administration Medical Center, Washington, D.C., USA

    Stephen I. Deutsch

  2. Georgetown University School of Medicine, Washington, D.C, USA

    Stephen I. Deutsch

  3. Tel Aviv University, Tel Aviv, Israel

    Abraham Weizman  & Ronit Weizman  & 

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© 1990 Plenum Publishing Corporation

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Deutsch, S.I., Deutsch, L.H., Weizman, R. (1990). Nonketotic Hyperglycinemia. In: Deutsch, S.I., Weizman, A., Weizman, R. (eds) Application of Basic Neuroscience to Child Psychiatry. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-0525-5_11

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  • DOI: https://doi.org/10.1007/978-1-4613-0525-5_11

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4612-7849-8

  • Online ISBN: 978-1-4613-0525-5

  • eBook Packages: Springer Book Archive

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