The Concept of Homology in Comparative Mammalian Teratology

  • James R. Miller


Naturally occurring animal models provide a fashionable topic in current mammalian biology. The subject is not a fad; the ancient Egyptians recognized the unity of human and veterinary medicine (Sigerist, 1951), and a considerable degree of interdependence has marked the development of the two disciplines. More recently, extensive reviews (Patterson et al., 1982; Leiter et al., 1987), proceedings of symposia (Lindsey and Capen, 1976; Kawamata and Melby, 1987) and workshops (Hackel, 1980), monographs (Andrews et al., 1979), and numerous research reports devoted to spontaneous animal models have appeared at regular intervals; the entry “Disease models, animal,” which first appeared in Index Medicus in 1970, regularly includes a number of references related to naturally occurring diseases; since 1969 the Institute of Laboratory Animal Resources (ILAR), with the support of the Animal Resources Branch of the National Institutes of Health, has maintained a registry of animal models and genetic stocks (Anonymous, 1972); and some of the techniques of molecular biology are being used to create new models (Evans et al., 1985; Hooper et al., 1987; Kuehn et al., 1987).


Growth Plate Cleft Palate Syrian Hamster Homologous Relation Ectodermal Dysplasia 
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Copyright information

© Plenum Press, New York 1990

Authors and Affiliations

  • James R. Miller
    • 1
  1. 1.Central Research DivisionTakeda Chemical IndustriesOsakaJapan

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