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Insoluble Dietary Fiber and Experimental Colon Cancer

Are We Asking the Proper Questions?

  • Chapter
Dietary Fiber

Abstract

The effects of insoluble dietary fiber on colonic carcinogenesis in animal models can be summarized by stating that this type of fiber inhibits, enhances, and has no effect on development of intestinal tumors. This vague conclusion is predicated on the fact that any assessment of the role of dietary fiber in studies of colonic carcinogenesis can only be made with an appreciation of the many sources of variability that contribute to the confusion surrounding the effect of fiber on the tumorigenic process.

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References

  • Abraham, R., Barbolt, T. A., and Rodgers, J. B., 1980, Inhibition by bran of the colonic cocarcinogenicity of bile salts in rats given dimethylhydrazine, Exp. Mol. Pathol 33: 133–143.

    Article  CAS  Google Scholar 

  • Barbolt, T. A., and Abraham, R., 1978, The effect of bran on dimethylhydrazine-induced colon carcinogenesis in the rat, Proc. Soc. Exp. Biol. Med 157: 656–659.

    CAS  Google Scholar 

  • Barbolt, T. A., and Abraham, R., 1980, Dose-response, sex difference, and the effect of bran in dimethylhydrazine-induced intestinal tumorigenesis, Toxicol. Appl. Pharmacol 55: 417–422.

    Article  CAS  Google Scholar 

  • Barnes, D. S., Clapp, N. K., Scott, D. A., Oberst, D. L., and Berry, S. G., 1983, Effects of wheat, rice, corn and soybean bran on 1,2-dimethylhydrazine-induced large bowel tumorigenesis in F344 rats, Nutr. Cancer 5: 1–9.

    Article  CAS  Google Scholar 

  • Bauer, H. G., Asp, N.-G., Oste, R., Dahlqvist, A., and Fredlund, P. E., 1979, Effect of dietary fiber on the induction of colorectal tumors and fecal β-glucuronidase activity in the rat, Cancer Res 39: 3752–3756.

    CAS  Google Scholar 

  • Calvert, R. J., Klurfeld, D. M., Subramaniam, S., Vahouny, G. V., and Kritchevsky, D., 1987, Reduction of colonic carcinogenesis by wheat bran independent of fecal bile acid concentration, J. Natl. Cancer. Inst 79: 875–880.

    CAS  Google Scholar 

  • Chen, V. F., Patchefsky, A. S., and Goldsmith, H. S., 1978, Colonic protection from dimethylhydrazine by a high fiber diet, Surg. Gynecol. Obstet 147: 503–506.

    CAS  Google Scholar 

  • Clapp, N. K., Henke, M. A., London, J. F., and Shock, T. L., 1984, Enhancement of 1,2-dimethylhydrazine-induced large bowel tumorogenesis in Balb/c mice by corn, soybean, and wheat brans, Nutr. Cancer 6: 77–85.

    Article  CAS  Google Scholar 

  • Cruse, J. P., Lewin, M. R., and Clark, C. G., 1978, Failure of bran to protect against experimental colon cancer in rats, Lancet 2: 1278–1280.

    Article  CAS  Google Scholar 

  • Dolara, P., Caderni, F., Bianchini, F., and Tanganelli, E., 1986, Nuclear damage of colon epithelial cell by the food carcinogen 2-amino-3-methylimidazo[4,5-f]quinoline (IQ) is modulated by dietary lipids, Nutr. Res 175: 255–258.

    CAS  Google Scholar 

  • Donham, K. J., Berg, J. W., Will, L. A., and Leininger, J. R., 1980, The effects of long-term ingestion of asbestos on the colon of F344 rats, Cancer 45: 1073–1084.

    Article  CAS  Google Scholar 

  • Donham, K. J., Will, L. A., Denman, D., and Leininger, J. R., 1984, The combined effects of asbestos ingestion and localized x-irradiation of the colon in rats, J. Environ. Pathol. Toxicol. Oncol 5: 299–308.

    CAS  Google Scholar 

  • Fleiszer, D., Murray, D., MacFarlane, J., and Brown, R. A., 1978, Protective effect of dietary fiber against chemically induced bowel tumours in rats, Lancet 2: 552–553.

    Article  CAS  Google Scholar 

  • Freeman, H. J., Spiller, G. A., and Kim, Y. S., 1978, A double-blind study on the effect of purified cellulose dietary fiber on 1,2-dimethylhydrazine-induced rat colonic nepolasia, Cancer Res 38: 2912–2917.

    CAS  Google Scholar 

  • Freeman, H. J., Spiller, G. A., and Kim, Y. S., 1980, A double-blind study on the effects of differing purified cellulose and pectin fiber diets on 1,2-dimethylhydrazine-induced rat colonic neoplasia, Cancer Res 40: 2661–2665.

    CAS  Google Scholar 

  • Freeman, H. J., Spiller, G. A., and Kim, Y. S., 1984, Effect of high hemicellulose corn bran in 1,2-dimehylhydrazine-induced rat intestinal neoplasia, Carcinogenesis 5: 261–264.

    Article  CAS  Google Scholar 

  • Galloway, D. J., Owen, R. W, Jarrett, F., Boyle, P., Hill, M. J., and George, W. D., 1986, Experimental colorectal cancer: The relationship of diet and faecal bile acid concentration to tumour induction, Br. J. Surg 73: 233–237.

    Article  CAS  Google Scholar 

  • Godfrey, K., 1985, Comparing the means of several groups, N. Engl. J. Med 313: 1450–1456.

    Article  CAS  Google Scholar 

  • Goodlad, R. A., Lenton, W., Ghatei, M. A., Adrian, T. E., Bloom, S. R., and Wright, N. A., 1987, Effects of an elemental diet, inert bulk and different types of dietary fibre on the response of the intestinal epithelium to refeeding in the rat and relationship to plasma gastrin, enteroglucagon, and PYY concentrations, Gut 28: 171–180.

    Article  CAS  Google Scholar 

  • Jacobs, L. R., 1983, Enhancement of rat colon carcinogenesis by wheat bran consumption during the stage of 1,2-dimethylhydrazine administration, Cancer Res 43: 4057–4061.

    CAS  Google Scholar 

  • Jacobs, L. R., and Lupton, J. R., 1982, Dietary wheat bran lowers colonic pH in rats, J. Nutr 112: 592–594.

    CAS  Google Scholar 

  • Jacobs, L. R., and Lupton, J. R., 1986, Relationship between colonic luminal pH, cell proliferation, and colon carcinogenesis in 1,2-dimethylhydrazine treated rats fed high fiber diets, Cancer Res 46: 1727–1734.

    CAS  Google Scholar 

  • Klurfeld, D. M., 1988, The role of dietary fiber in gastrointestinal disease, J. Am. Diet. Assoc 87: 1172–1177.

    Google Scholar 

  • Klurfeld, D. M., and Kritchevsky, D., 1986, Update on dietary fat and cancer, Proc. Soc. Exp. Biol. Med 183: 287–292.

    CAS  Google Scholar 

  • Klurfeld, D. M., Weber, M. M., Buck, C. L., and Kritchevsky, D., 1986, Dose-response of colonic carcinogenesis to different amounts and types of cellulose, Fed. Proc 45: 1076.

    Google Scholar 

  • Klurfeld, D. M., Weber, M. M., and Kritchevsky, D., 1987, Inhibition of chemically induced mammary and colon tumor promotion by caloric restriction in rats fed increased dietary fat, Cancer Res 47: 2759–2762.

    CAS  Google Scholar 

  • Kritchevsky, D., Weber, M. M., and Klurfeld, D. M., 1987, Weight gain in dimethylhydrazine-treated rats: Effect of commercial or semipurified diet, Nutr. Rep. Int 35: 871–876.

    CAS  Google Scholar 

  • LaMont, J. T., and O’Gorman, T. A., 1978, Experimental colon cancer, Gastroenterology 75:1157–1169.

    CAS  Google Scholar 

  • Nigro, N. D., Bull, A. W., Kloper, B. A., Pak, M. S., and Campbell, R. L., 1979, Effect of dietary fiber on azoxymethane-induced intestinal carcinogenesis in rats, J. Natl. Cancer Inst 62: 1097–1102.

    CAS  Google Scholar 

  • Pozharisski, K. M., 1973, TUmours of the intestines, in: Pathology of Tumours in Laboratory Animals, Vol. 1, Part 1 (V. S. Hirusov, ed.), International Agency for Research on Cancer, Lyons, pp. 87–100.

    Google Scholar 

  • Prizont, R., 1987, Absence of large bowel tumors in rats injected with 1,2-dimethylhydrazine and fed high dietary cellulose, Dig. Dis. Sci 32: 1418–1421.

    Article  CAS  Google Scholar 

  • Reddy, B. S., and Mori, H., 1981, Effect of dietary wheat bran and dehydrated citrus fiber on 3,2’-dimethyl-4-aminobiphenyl-induced intestinal carcinogenesis in F344 rats, Carcinogenesis 2: 21–25.

    Article  CAS  Google Scholar 

  • Reddy, B. S., Mori, H., and Nicolais, M., 1981, Effect of dietary wheat bran and dehydrated citrus fiber on azoxymethane-induced intestinal carcinogenesis in Fischer 344 rats, J. Natl. Cancer Inst 66: 553–557.

    CAS  Google Scholar 

  • Reddy, B. S., Maeura, Y., and Wayman, M., 1983, Effect on dietary corn bran and autohydrolyzed lignin on 3,2’-dimethyl-4-aminobiphenyl-induced intestinal carcinogenesis in male F344 rats, J. Natl. Cancer Inst 71: 419–423.

    CAS  Google Scholar 

  • Roberts-Andersen, J., Mehta, T., and Wilson, R. B., 1987, Reduction of DMH-induced colon tumors in rats fed psyllium husk or cellulose, Nutr. Cancer 10: 1129–136.

    Article  Google Scholar 

  • Trudel, J. I., Senterman, M. K., and Brown, R. A., 1983, The fat/fiber antagonism in experimental colon carcinogenesis, Surgery 94: 691–695.

    CAS  Google Scholar 

  • Ward, J. M., Yamamoto, R. S., and Weisburger, J. H., 1973, Cellulose dietary bulk and azoxymethaneinduced intestinal cancer, J. Natl. Cancer Inst 51: 713–715.

    CAS  Google Scholar 

  • Watanabe, K., Reddy, B. S., Weisburger, J. H., and Kritchevsky, D., 1979, Effect of dietary alfalfa, pectin, and wheat bran on azoxymethane- or methylnitrosourea-induced colon carcinogenesis in F344 rats, J. Natl. Cancer Inst 63: 141–145.

    CAS  Google Scholar 

  • Wilpart, M., and Roberfroid, M., 1987, Intestinal carcinogenesis and dietary fibers: The influence of cellulose or Fybogel chronically given after exposure to DMH, Nutr. Cancer 10: 39–51.

    Article  CAS  Google Scholar 

  • Wilson, R. B., Hutcheson, D. P., and Widerman, L., 1977, Dimethylhydrazine-induced colon tumors in rats fed diets containing beef fat or corn oil without wheat bran, Am. J. Clin. Nutr 30: 176–181.

    CAS  Google Scholar 

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Author information

Authors and Affiliations

  1. The Wistar Institute of Anatomy and Biology, Philadelphia, Pennsylvania, 19104, USA

    David M. Klurfeld

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  1. David M. Klurfeld
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Editor information

Editors and Affiliations

  1. The Wistar Institute, Philadelphia, Pennsylvania, USA

    David Kritchevsky

  2. Astra Associates, Inc., McLean, Virginia, USA

    Charles Bonfield

  3. Veterans Administration Medical Center, Lexington, Kentucky, USA

    James W. Anderson

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© 1990 Plenum Press, New York

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Klurfeld, D.M. (1990). Insoluble Dietary Fiber and Experimental Colon Cancer. In: Kritchevsky, D., Bonfield, C., Anderson, J.W. (eds) Dietary Fiber. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-0519-4_30

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  • DOI: https://doi.org/10.1007/978-1-4613-0519-4_30

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4612-7846-7

  • Online ISBN: 978-1-4613-0519-4

  • eBook Packages: Springer Book Archive

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