Abstract
Bile acids are the major route of steroid excretion, a phenomenon that has been exploited as a mechanism for lowering serum cholesterol and coronary heart disease risk (Lipid Research Clinics Program, 1984). Alteration of bile acid metabolism by dietary fiber has been of interest as a result of the potential involvement of changes in bile acid metabolism in the etiology of a variety of important diseases of Western populations (Story, 1979). Dietary fiber also increases fecal bulk and, as a result, dilutes the contents of the colon, including bile acids. Bile acid concentrations have been linked with colon cancer susceptibility; thus, alterations in bile acid concentrations by dietary fiber have been suggested as a mechanism for reduced cancer risk, a second epidemiologic observation.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Anderson, J. W., Story, L., Sieling, B., Chen, W.-J. L., Petro, M. S., and Story, J. A., 1984, Hypercholesterolemic effects of oat bran or bean intake for hypercholesterolemic men, Am. J. Clin. Nutr 40: 1146–1155.
Beher, W. T., Beher, M. E., and Rao, B., 1967, Turnover of cholic and chenodeoxycholic acids in normal and hypothsectomized rats, Life Sci 6: 866–868.
Chen, W.-J. L., and Anderson, J. W., 1986, Hypocholesterolemic effects of soluble fibers, in: Dietary Fiber: Basic and Clinical Aspects (G. V. Vahouny and D. Kritchevsky, eds.), Plenum Press, New York, pp. 275–286.
Chen, W.-J. L., Anderson, J. W., and Jennings, D., 1984, Propionate may mediate the hypocholesterolemic effects of certain soluble plant fibers in cholesterol-fed rats, Proc. Soc. Exp. Biol. Med. 175: 215–218.
Coyne, M. J., Bonouris, G. G., Goldstein, L. I., and Schoenfield, L. J., 1976, Effect of chenodeoxycholic acid and phenobarbital on the rate limiting enzymes of hepatic cholesterol and bile acid synthesis in patients with gallstones, J. Lab. Clin. Med 87: 281–291.
Gormley, T. R., Kevany, J., Egan, J. P., and McFarlane, R., 1977, Effect of apples on serum cholesterol levels in humans, Ir. J. Food Sci. Technol 3: 101–109.
Kelley, M. J., and Story, J. A., 1987, Short-term changes in hepatic HMG-CoA reductase in rats fed diets containing cholesterol or oat bran, Lipids 22: 1057–1059.
Kirby, R. W., Anderson, J. W., Sieling, B., Rees, E. D., Chen, W.-J. L., Miller, R. E., and Kay, R. M., 1981, Oat bran intake selectively lowers serum low density lipoprotein concentrations: Studies of hypercholesterolemic men, Am. J. Clin. Nutr 34: 824–829.
Kritchevsky, D., and Story, J. A., 1974, Binding of bile salts in vitro by nonnutritive fiber, J. Nutr 104: 458–462.
Lipid Research Clinics Program, 1984, The lipid research clinics coronary primary prevention trial results. II. The relationship of reduction of incidence of coronary heart disease to cholesterol lowering, J.A.M.A 251: 365–374.
Narisawa, T., Magadia, N. E., and Wynder, E. L., 1974, Promoting effect of bile acids on colon carcinogenesis after intrarectal instillation of N-methyl-N-nitroguanidine in rats, Cancer Res 53: 1093–1097.
Ponz de Leon, M., Carulli, N., Loria, P., and Zirone, F., 1979, The effect of chenodeoxycholic acid (CDCA) on cholesterol absorption, Gastroenterology 77: 223–230.
Portman, O. W., 1960, Nutritional influences on the metabolism of bile acids, Am. J. Clin. Nutr 8: 462–470.
Portman, O. W., and Murphy, P., 1958, Excretion of bile acids and β-hydroxysterols by rats, Arch. Biochem. Biophys 76: 367–371.
Qureshi, A. A., Burger, W. C., Peterson, D. M., and Elson, C. E., 1986, The structure of an inhibitor of cholesterol biosynthesis isolated from barley, J. Biol. Chem 261: 10544–10550.
Robertson, J. A., Brydon, W. G., Tadesse, K., Wenham, P., Walls, A., and Eastwood, M. A., 1979, The effect of raw carrot on serum lipids and colon function, Am. J. Clin. Nutr 32: 1889–1892.
Story, J. A., 1979, Dietary fiber: Its role in diverticular disease, colon cancer and coronary heart disease, in: Biochemistry of Nutrition, Vol. 1 (A. Neuberger and T. H. Jukes, eds.), University Park Press, Baltimore, pp. 189–205.
Story, J. A., 1985, Dietary fiber and lipid metabolism, Proc. Soc. Exp. Biol. Med 180: 447–452.
Story, J. A., 1986, Modification of steroid excretion in response to dietary fiber, in: Dietary Fiber: Basic and Clinical Aspects (G. V. Vahouny and D. Kritchevsky, eds.), Plenum Press, New York, pp. 253–264.
Story, J. A., and Kritchevsky, D., 1976, Comparison of the binding of various bile acids and bile salts by several types of fiber, J. Nutr 106: 1292–1294.
Story, J. A., and Thomas, J. N., 1982, Modification of bile acid spectrum by dietary fiber, in: Dietary Fiber in Health and Disease (G. V. Vahouny and D. Kritchevsky, eds.), Plenum Press, New York, pp. 193–201.
Thomas, J. N., Kelley, M. J., and Story, J. A., 1984, Alteration of regression of cholesterol accumulation in rats by dietary pectin, Br. J. Nutr 51: 339–345.
Wilpart, M., Mainguet, P., Maskens, A., and Roberfroid, M., 1983, Structure-activity relationship amongst biliary acids showing co-mutagenic activity towards dimethylhydrazine, Carcinogenesis 4: 1239–1241.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1990 Plenum Press, New York
About this chapter
Cite this chapter
Story, J.A., Furumoto, E.J. (1990). Dietary Fiber and Bile Acid Metabolism. In: Kritchevsky, D., Bonfield, C., Anderson, J.W. (eds) Dietary Fiber. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-0519-4_26
Download citation
DOI: https://doi.org/10.1007/978-1-4613-0519-4_26
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4612-7846-7
Online ISBN: 978-1-4613-0519-4
eBook Packages: Springer Book Archive