Abstract
Ciliated cells are the most numerous (30-65%) of the eight cell types on the human respiratory epithelium (Jeffrey and Reid, 1975; Plopper et al., 1983). These cells are restricted to the central airways: the trachea, where they form an almost continuous cover, and the primary, secondary, and tertiary bronchioles, where the proportion of other cells increases. Thus, the surface of the central airways can be viewed as a continuous carpet of cilia with intervening islands of nonciliated cells (e.g., goblet or serous cells). Infection of the ciliated respiratory epithelium (i.e., bronchitis) is clearly distinguishable pathologically from infection of the nonciliated terminal alveoli (i.e., pneumonia). Each ciliated cell extends a tuft of approximately 200 cilia from one face of the cell body (5-µm cell diameter, density of cilia 6-8 µm-2) into the airway lumen (Sleigh et al., 1988). Human cilia measure 6 µm in length in larger airways and 5 µm in smaller bronchioles (Sleigh et al., 1988). Such shortening of cilia toward the lung periphery has also been documented in mouse and rat (Jeffrey and Reid, 1975).
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Tuomanen, E. (1990). The Surface of Mammalian Respiratory Cilia Interactions between Cilia and Respiratory Pathogens. In: Bloodgood, R.A. (eds) Ciliary and Flagellar Membranes. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-0515-6_14
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