Regulation of the Expressed Idiotypic Repertoire in the Normal Immune Response of the Aged

  • Edmond A. Goidl
  • Susan J. Martin McEvoy
  • Francisco A. Bonilla
  • Azad Kaushik
  • Constantin A. Bona
Conference paper
Part of the GWUMC Department of Biochemistry Annual Spring Symposia book series (GWUN)

Abstract

Aging is accompanied by a gradual decline of certain physiological functions. Not the least of these are the effector functions of the immune system. Most aging animals demonstrate a progressive decline in their capacity to mount primary immune responses when compared in magnitude and heterogeneity of antibody affinity with that seen in the immune response of young adult animals.

Keywords

Albumin Chromium Tuberculosis Dextran Transferrin 

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Copyright information

© Plenum Press, New York 1990

Authors and Affiliations

  • Edmond A. Goidl
    • 1
  • Susan J. Martin McEvoy
    • 1
  • Francisco A. Bonilla
    • 2
  • Azad Kaushik
    • 2
  • Constantin A. Bona
    • 2
  1. 1.Department of Microbiology and Immunology, School of MedicineUniversity of Maryland at BaltimoreBaltimoreUSA
  2. 2.Department of MicrobiologyMount Sinai School of MedicineNew YorkUSA

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