Changes in Receptors and Signal Transduction Events during Aging
Physiological and behavioral responses to many classes of stimuli are altered during aging. Best studied among these have been hormone and neurotransmitter signal transduction sequences. Age-related alterations in these processes have been grouped into receptor and postreceptor changes. Our laboratory has focused on three systems that exhibit representative age-associated alterations in signal transduction mechanisms: (1) dopaminergic regulation of motor function, (2) estrogenic regulation of uterine anabolic function, and (3) α-adrenergic regulation of parotid secretory function (for review, see Roth, 1985).
KeywordsEstrogenic Dopamine Superoxide Serotonin Histamine
Unable to display preview. Download preview PDF.
- Calderini, G., Bellini, F., Bonetti, A. C., Galbaiti, E., Teoloto, S., and Toffano, G., 1986, Effect of aging on phospholipid senestitive Ca+ + dependent protein kinase in the rat brain, Abst. Soc. Neurosci. 12: 275.Google Scholar
- Chopra, R., Nagel, J., and Adler, W., 1987, Decreased response of T cells from elderly individuals to phytohemogglutinin (PHA) stimulation can be augmented by phorbol myristate acetate (PMA) in conjunction with Ca-ionophore A23187, Gerontologist 27: 204A.Google Scholar
- Chuknyiska, R. S., Blackman, M. R., and Roth, G. S., 1987, Ionophore A23187 partially reverses LH secretory defect of pituitary cells from old rats, Am. J. Physiol. 258: E233–E237.Google Scholar
- Cohen, M. L., and Berkowitz, B. A., 1976, Vascular contraction: Effect of age and extracellular calcium, Blood Vessels 67: 139–149.Google Scholar
- Orida, N., and Feldman, J. D., 1982, Age related deficiency in calcium uptake by mast cells, Fed. Proc. 41: 822.Google Scholar
- Peterson, C., Nicholls, D. G., and Gibson, G. E., 1985, subsynaptosomal distribution of calcium during aging and 3,4-diaminopyridine treatment, Neurobiol. Aging 6: 297–304.Google Scholar
- Roth, G. S., 1985, Effects of aging on mechanisms of a-adrenergic and dopaminergic action, Fed. Proc. 45: 60–64.Google Scholar