Activity of Monkey Striatal and Dopamine Neurons During the Performance of Delayed Response Tasks
The striatum (caudate nucleus and putamen) lies at the crossroads of major forebrain centers involved in the organization of behavioral output. It receives afferents from limbic structures and from association and motor cortical areas dealing with the cognitive and motivational control of behavior, the preparation of behavioral acts and the control of ongoing movements. Since a major part of basal ganglia output is directed back to the frontal lobe, the functions of the striatum are intimately linked to those of prefrontal, premotor and motor cortex. The striatum is also innervated by midbrain dopamine neurons which are involved in basic behavioral activating processes and goal-directed behavior. The study of behavioral deficits in Parkinsonian patients and experimentally lesioned animals demonstrates that the intact striatal dopamine innervation is important for the expression of striatal behavioral control functions.
KeywordsDopamine Neurol Catecholamine MPTP Nogo
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