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The Basal Ganglia IV pp 205–212Cite as

Efficacy of Intrastriatal Transplants: Role of Trophic Factors

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Part of the book series: Advances in Behavioral Biology ((ABBI,volume 41))

Abstract

The dopaminergic (DA) substantia nigra-ventral tegmental area (SN-VTA) projection to the caudate-putamen (striatum) is critical in the control of motor behavior. Clinically, Parkinson’s disease reflects a massive degeneration of the nigrostriatal system (Bernheimer et al., 1973). The replacement of the system by intrastriatal transplants of fetal midbrain suspensions has resulted in improvements in some patients (Sladek and Shoulson, 1988; Lindvall et al., 1989; Freed et al., 1990). In experimental animals, it has been shown that fetal midbrain cells survive transplantation, extend processes and synthesize DA (Perlow et al., 1979; Björklund et al., 1980, 1983a, 1983b). Such transplants ameliorate certain deficits associated with the loss of DA input to the striatum (Björklund et al., 1987; Yurek and Sladek, 1990). Similar transplants reverse motor abnormalities produced by unilateral denervation (Perlow et al, 1979; Björklund et al, 1980, 1983a, 1983b) including apomorphine or amphetamine-induced rotation behavior. Transplants of adrenal medulla have also been shown to ameliorate some behavioral deficits (Allen et al., 1989; Hansen et al., 1989; Lieberman et al., 1989).

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Authors and Affiliations

  1. Anatomy and Neurobiology Department, University of California, Irvine, Irvine, CA, 92717, USA

    Sandra E. Loughlin, Tiffany P. Lee & James H. Fallon

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  1. Sandra E. Loughlin
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  2. Tiffany P. Lee
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  1. INSERM, Paris, France

    Gérard Percheron

  2. University of Melbourne, Melboune, Australia

    John S. McKenzie

  3. Université R. Descartes, Paris, France

    Jean Féger

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© 1994 Plenum Press, New York

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Loughlin, S.E., Lee, T.P., Fallon, J.H. (1994). Efficacy of Intrastriatal Transplants: Role of Trophic Factors. In: Percheron, G., McKenzie, J.S., Féger, J. (eds) The Basal Ganglia IV. Advances in Behavioral Biology, vol 41. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-0485-2_22

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