Nucleoside Transport Protein: Properties and Regulation

  • Anwar S. A. Abd-Elfattah
  • Samir Mardini
  • Jian-Hua Guo
  • Mohanad I. Shehab
  • Nashaat El-Singaby
  • Shin-Ping Gao
  • El-Mostafa El-Guessab
Part of the Developments in Cardiovascular Medicine book series (DICM, volume 181)


Membrane-bound purinergic receptors mediate several physiological responses of adenine nucleotides and nucleosides. These receptors are located on the external side of the plasma membranes. For example, adenosine receptor activation and subsequent signal transduction is determined by the concentration of the ligand in the vicinity of the receptor. Therefore, adenosine transport (release and uptake) via nucleoside transporters, phosphorylation by adenosine kinase and deamination play a significant role in the degree by which adenosine receptors are activated. Extracellular ATP activates purinegic receptors (P2) while ATP uptake (1,2) and dephosphorylation by ecto-nucleotidases result in termination of receptor activation. On the other hand, nucleosides produced inside the cell during ischemic and hypoxic stress must be removed from the intracellular domain either by a transport mechanism or by incorporation into the salvage pathway of nucleotides inside cells. Therefore, a bidirectional nucleoside transporter is necessary for regulation of nucleoside uptake and release during normal and pathophysiologic conditions. This Chapter will cover the historical aspects of the discovery and characterization of adenine nucleoside transporters in different cell models in general and in cardiac muscle in particular.


Adenine Nucleotide Adenosine Deaminase Myocardial Stunning Nucleoside Transport Endogenous Adenosine 
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Copyright information

© Kluwer Academic Publishers 1996

Authors and Affiliations

  • Anwar S. A. Abd-Elfattah
    • 1
  • Samir Mardini
    • 1
  • Jian-Hua Guo
    • 1
  • Mohanad I. Shehab
    • 1
  • Nashaat El-Singaby
    • 1
  • Shin-Ping Gao
    • 1
  • El-Mostafa El-Guessab
    • 1
  1. 1.Division of Cardiothoracic Surgery, Department of Surgery, Medical College of VirginiaVirginia Commonwealth UniversityRichmondUSA

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