Assessment of Interstitial Fluid Adenosine: Implications for Exogenous and Endogenous Adenosine-Mediated Cardioprotection

  • David G. L. Van Wylen
Part of the Developments in Cardiovascular Medicine book series (DICM, volume 181)


This chapter focuses on a specific aspect of the cardioprotective properties of adenosine, namely how the sampling of myocardial interstitial fluid (ISF) and the estimate of the changes in ISF adenosine provides insight into the protective actions of adenosine. As such, this chapter will concentrate on adenosine itself, both endogenously produced as well as exogenously administered, and will describe the effectiveness of certain pharmaceutical strategies designed to augment endogenous ISF adenosine. Because of the emphasis on the assessment of ISF adenosine, the wealth of important and interesting data dealing with pharmacological agents which are cardioprotective due to their direct actions at the adenosine receptor will not be discussed in this chapter.


Left Anterior Descend Adenosine Receptor Ischemic Precondition Adenosine Deaminase Myocardial Stunning 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Kluwer Academic Publishers 1996

Authors and Affiliations

  • David G. L. Van Wylen
    • 1
  1. 1.Department of BiologySt. Olaf CollegeNorthfieldUSA

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