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Purines and Myocardial Protection pp 469–480Cite as

Role of Activation of Ecto-5’-Nucleotidase for Cardioprotection in Ischemic and Reperfusion Injury: Role of Purine and Adenosine Metabolism

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Part of the book series: Developments in Cardiovascular Medicine ((DICM,volume 181))

Abstract

Adenosine is known to regulate myocardial and coronary circulatory functions (1–4). The effects of adenosine are mediated by several distinct receptors (5,6), i.e., A1, A2 and A3 receptors. A1 and A3 adenosine receptors, mainly located in atrial and ventricular myocardium and sinoatrial/atrioventricular nodes, are responsible for inhibition of adenylyl cyclase activity. A2 adenosine receptors, mainly located in coronary endothelial and smooth muscle cells, are responsible for stimulation of this adenylyl cyclase activity. Adenosine has been known to attenuate the extends of myocardial ischemia, stunning and infarction. The rationale of the beneficial effects of adenosine does not seem simple. This is because myocardial ischemia and reperfusion injury is caused by 1) activated leukocytes and platelets (7,8), 2) ATP depletion and Ca overload of myocardium (9,10,11), and 3) catecholamine release from the presynaptic nerves (12,13), as well as 4) the impaired coronary circulation (14). Intriguingly, adenosine attenuates all of these deleterious actions and thereby attenuates ischemia/reperfusion injury (1–4). Recently, the role of adenosine for the infarct size-limiting effect of ischemic preconditioning has been extensively focused. Ischemic preconditioning means that brief periods of ischemia before sustained ischemia limit infarct size (15,16). Liu et al. (17) demonstrated that an exposure to 8-sulfophenyltheophylline blunts the infarct size-limiting effect of ischemic preconditioning.

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Author information

Authors and Affiliations

  1. The First Department of Medicine, Osaka University School of Medicine, Osaka, Japan

    Masafumi Kitakaze, Koichi Node, Tetsuo Minamino, Kazuo Komamura, Masatsugu Hori & Takenobu Kamada

  2. Department of the Information Science, Osaka University School of Medicine, Osaka, Japan

    Michitoshi Inoue

Authors
  1. Masafumi Kitakaze
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  2. Koichi Node
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  3. Tetsuo Minamino
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  4. Kazuo Komamura
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  5. Michitoshi Inoue
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  6. Masatsugu Hori
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  7. Takenobu Kamada
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Editor information

Editors and Affiliations

  1. Cardiothoracic Division, Department of Surgery, Box 890532, MCV Station, Richmond, VA, 23298-0532, USA

    Anwar-Saad A. Abd-Elfattah MS, Ph.D.

  2. Department of Surgery, Medical College of Virginia, Richmond, Virginia, 23298-0532, USA

    Andrew S. Wechsler M.D.

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© 1996 Kluwer Academic Publishers

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Kitakaze, M. et al. (1996). Role of Activation of Ecto-5’-Nucleotidase for Cardioprotection in Ischemic and Reperfusion Injury: Role of Purine and Adenosine Metabolism. In: Abd-Elfattah, AS.A., Wechsler, A.S. (eds) Purines and Myocardial Protection. Developments in Cardiovascular Medicine, vol 181. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-0455-5_30

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  • DOI: https://doi.org/10.1007/978-1-4613-0455-5_30

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-8056-6

  • Online ISBN: 978-1-4613-0455-5

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