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Purines and Myocardial Protection pp 421–431Cite as

Myocardial Preconditioning: From a Model to a Phenomenon

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Part of the book series: Developments in Cardiovascular Medicine ((DICM,volume 181))

Abstract

Originally, the term ischemic preconditioning described the observation that four 5 minute episodes of coronary artery occlusion in dogs followed by prolonged ischemia (40 minutes) and reperfusion resulted in a marked reduction in the rate of ATP depletion and limitation of myocardial infarction (1). Sustained ischemia alone produces about 30% myocardial infarction of the area at risk. These observations have been reproduced in small and large animal models of coronary artery occlusion and reperfusion whereby a single episode (or multiple episodes) of ischemia and reperfusion protected the myocardium against infarction, but failed to augment recovery of ventricular function in the same model.

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Author information

Authors and Affiliations

  1. Department of Surgery, Division of Cardiothoracic Surgery, Medical College of Virginia, Virginia Commonwealth University, Richmond, Virginia, USA

    Anwar-Saad A. Abd-Elfattah, El-Mostafa El-Guessab & Jian-Hua Guo

Authors
  1. Anwar-Saad A. Abd-Elfattah
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  2. El-Mostafa El-Guessab
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  3. Jian-Hua Guo
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Editor information

Editors and Affiliations

  1. Cardiothoracic Division, Department of Surgery, Box 890532, MCV Station, Richmond, VA, 23298-0532, USA

    Anwar-Saad A. Abd-Elfattah MS, Ph.D.

  2. Department of Surgery, Medical College of Virginia, Richmond, Virginia, 23298-0532, USA

    Andrew S. Wechsler M.D.

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© 1996 Kluwer Academic Publishers

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Abd-Elfattah, AS.A., El-Guessab, EM., Guo, JH. (1996). Myocardial Preconditioning: From a Model to a Phenomenon. In: Abd-Elfattah, AS.A., Wechsler, A.S. (eds) Purines and Myocardial Protection. Developments in Cardiovascular Medicine, vol 181. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-0455-5_26

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  • DOI: https://doi.org/10.1007/978-1-4613-0455-5_26

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-8056-6

  • Online ISBN: 978-1-4613-0455-5

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